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Biological physics

News and Updates

Projects and Programs

NIST Cell-Free Workshop

The Cell-Free Workshop sought to identify and prioritize actionable steps towards more reproducible and comparable cell-free systems for practical applications

Publications

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di- heptamer macromolecular assembly

Author(s)
Xingjian Xu, Raquel Ruiz, Kaylin Adipietro, Christopher Peralta, Danya Ben-Hail, Kristen Varney, Mary Cook, Braden Roth, Paul Wilder, Thomas E. Cleveland, Alexander V. Grishaev, Heather Neu, Sarah Michel, Wenbo Yu, Dorothy Beckett, Richard Rustandi, Alex MacKerell, Amedee des Georges, Edwin Pozharski, David Weber
Targeting Clostridium difficile infection is challenging because treatment options are limited, and high recurrence rates are common. One reason for this is

The FeoC [4Fe4S] Cluster Is Redox-Active and Rapidly Oxygen-Sensitive

Author(s)
Aaron T. Smith, Richard O. Linkous, Nathan Max, Alexandrea E. Sestok, Veronika A. Szalai, Kelly N. Chacon
The acquisition of iron is essential to establishing virulence among most pathogens. Under acidic and/or anaerobic conditions, most bacteria utilize the widely

Topology, Landscapes, and Biomolecular Energy Transport

Author(s)
Justin E. Elenewski, Kirill Velizhanin, Michael P. Zwolak
While ubiquitous, energy redistribution remains a poorly understood facet of the nonequilibrium thermodynamics of biomolecules. At the molecular level, finite

Software