Standard Reference Materials

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The downloadable version of the SRM Catalog is updated annually. For the latest product availability for order, go to the NIST Store, https://shop.nist.gov.

Users of a NIST SRM or RM should ensure that the certificate/report in their possession is current. Find Current SRM/RM Certificates, Reports of Investigation, and Safety Data Sheets using the NIST Store’s Product Search Box.

Due to world events, all shipping to Russia, Belarus, and Ukraine has ceased. As a result, the Office of Reference Materials will not be accepting or processing orders to these countries for the foreseeable future.

News and Updates

A microscopic image of NISTCHO cells that are stained blue and green on a black background..

NIST’s ‘Living Reference Material’ Could Accelerate R&D of Lifesaving Biological Drugs

September 8, 2025

The NIST reference material, called NISTCHO, will help the biopharmaceutical industry develop new drugs more quickly and ensure that they are safe and effective

A woman wearing a lab coat and safety glasses stares into a large microscope.

New NIST Reference Material to Strengthen Quality Control for Biological Drugs

July 31, 2025

Impurities in these drugs can cause undesirable immune responses in patients and can significantly drive up costs for drug manufacturers.

A Particle Size SRM for Training and Qualifying Visual Inspection Analysts

July 31, 2025

NIST received requests from scientists in the biopharmaceutical industry, instrument vendors, and from the U.S. Food and Drug Administration to develop a

SRM 2323 - Step Height Standard for Areal Surface Topography Measurement

NIST Developed an SRM to Aid the Forensic Analysis of Firearms and Toolmarks

July 30, 2025

When a gun is fired, microscopic markings are left on the expelled bullet and cartridge case. Forensic firearm and toolmark examiners compare these markings to

Projects and Programs

NIST HER2 Genomic DNA Standard Reference Material, SRM® 2373

Ongoing

The amplification of the gene for HER2 occurs in approximately 20 to 25% of breast cancers. The accurate measurement of this biomarker is important for the proper treatment with anti-HER2 therapeutics. Clinical laboratories are beginning to utilize accurate and sensitive diagnostic tests based on

Press Coverage

Setting Standards for Stool

January 19, 2024

Microbiome studies have yielded hundreds of ideas for ways to detect and influence human health, but the field struggles with reproducibility...

The World Depends on a Strange Collection of Items. They're Not Cheap

Veritasium YouTube Channel

November 19, 2022

Steven Choquette, Benjamin Place, and Johanna Camara talk about the world of Standard Reference Materials.

Keeping up America’s standards is the job of NIST

The Economist

August 17, 2022

Melissa Phillips and NIST collaborators explain why NIST reference materials are so important to industry, monitoring environmental and human health, and much

Made to measure: why we can’t stop quantifying our lives

The Guardian

May 26, 2022

Dr. Steven Choquette, Director of the NIST Office of Reference Materials, is quoted in this article about metrology.

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