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Search Publications by

Sheng Lin-Gibson (Fed)

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Displaying 26 - 50 of 107

Imaging Cells in Polymer Scaffolds by X-Ray Microcomputed Tomography

May 11, 2011
Shauna M. Dorsey, Sheng Lin-Gibson, Carl Simon Jr.
We have investigated the ability of X-ray microcomputed tomography (CT) to make quantitative, three-dimensional (3D) measurements of cell adhesion and proliferation in polymeric tissue engineering scaffolds. The most common method for examining cells in

Modulus-Driven Differentiation of Marrow Stromal Cells in 3D Is Independent of Cytoskeletal Integrity

April 11, 2011
Carl G. Simon Jr., Kaushik Chatterjee, Sapun Parekh, Sheng Lin-Gibson, Nicole M. Moore, Marcus T. Cicerone, Marian F. Young
Cell functions such as proliferation, migration, and differentiation are key physiological processes that are influenced by the physiochemical extracellular environment. We report on the effect of three-dimensional (3D) scaffold modulus on human bone

In situ Formation of Silver Nanoparticles in Photocrosslinking Polymers

February 2, 2011
Yajun Cheng, Diana N. Zeiger, John A. Howarter, Xinran Zhang, Nancy Lin, Joseph M. Antonucci, Sheng Lin-Gibson
Nanocomposites of difunctional methacrylate polymer/silver nanoparticles have been synthesized by coupling photoinitiated free radical polymerization with in situ silver ion reduction. A polymerizable methacrylate bearing a secondary amino function group

Controlled in situ Nanocavitation in Polymeric Materials

January 18, 2011
Yajun Cheng, Joseph M. Antonucci, Steven Hudson, Nancy Lin, Xinran Zhang, Sheng Lin-Gibson
A new strategy to produce polymer-inorganic composites with ultra low volume shrinkage has been developed. Small amount of cavitation agent, acetone dicarboxylic acid (ADCA), was introduced into acrylate-glass composites and decomposed in situ to carbon

Effects of Polymeric Nanogratings on Cell Orientation

December 30, 2010
Nancy J. Lin, Sheng Lin-Gibson, Jirun Sun, Yifu Ding
Surface topography is known to play a critical role in the biological response to materials, with surface features on the order of both microns and nanometers altering cell response, including morphology, adhesion, cytoskeletal orientation, and gene

Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation

November 1, 2010
Carl G. Simon Jr., Sapun Parekh, Marcus T. Cicerone, Sheng Lin-Gibson, Kaushik Chatterjee, Marian F. Young
There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human bone

Cell Contact Guidance in Response to Nanopattern Shape and Height

October 18, 2010
Sheng Lin-Gibson, Jirun Sun, Nancy J. Lin, Jing N. Zhou, Hyun W. Ro, Christopher L. Soles, Marcus T. Cicerone, Yifu Ding
Understanding the correlation between cell contact guidance (CG) and nanoscale surface features is vital in designing advanced medical devices to manipulate cell behaviors. Nanoscale surface features that mimic extracellular matrix are critical

Effect of 3D Hydogel Scaffold Modulus and Topology on Human Bone Marrow Stromal Cell Fate

September 1, 2010
Kaushik Chatterjee, Sheng Lin-Gibson, Sapun Parekh, Nicole M. Moore, Marcus T. Cicerone, marian F. young, Carl Simon Jr.
There is growing recognition that cells can sense and respond to the physical cues from their environment, such as stiffness, mechanical loading and topology. Physical properties of the matrix can direct cellular response and are critical in the design of


August 21, 2010
Yajun Cheng, Xinran Zhang, Diana N. Zeiger, Nancy Lin, Joseph M. Antonucci, Sheng Lin-Gibson
Polymeric nanocomposites containing silver are known to exhibit antibacterial activity. Here we demonstrate the synthesis and characterization of dimethacrylate/silver nanocomposites by coupling photopolymerization with in situ silver ion reduction. An

Thermodynamic Underpinnings of Cell Alignment on Controlled Topographies

August 17, 2010
Yifu Ding, Jirun Sun, Hyun W. Ro, Zhen Wang, Jing N. Zhou, Nancy J. Lin, Sheng Lin-Gibson, Marcus T. Cicerone, Christopher L. Soles
Cells sense and respond to the chemical, topographical, and mechanical features of their substrate and extracellular matrix. Shape and locomotive response to these features is termed contact guidance (CG) and is of vital importance in understanding many

Adhesion research at the National Institute of Standards and Technology (NIST)

April 1, 2010
Christopher M. Stafford, Adam J. Nolte, Gale A. Holmes, Sheng Lin-Gibson, John A. Howarter
NIST s involvement in adhesion research has been wide ranging and is ultimately in response to interactions between individual project leaders and our industrial partners. In this way, NIST s participation in the Adhesion Society has been instrumental in

Novel Dimethacrylates with Quaternary Ammonium Functionalities for Reduced Bacteria Adhesion

April 1, 2010
Nancy J. Lin, Joseph M. Antonucci, Diana N. Zeiger, Kathy Tang, Bruce O. Fowler, Sheng Lin-Gibson
Biofilm growth and secondary caries have resulted in the failure of many dental composite restorations. One approach to address this issue is the modification of dental materials to reduce bacterial adhesion and biofilm growth. Quaternary ammonium salts

Effects of sample preparation on bacterial colonization of polymers

October 19, 2009
Diana N. Zeiger, Christopher Stafford, Yajun Cheng, Stefan D. Leigh, Sheng Lin-Gibson, Nancy Lin
Characterization of materials developed for medical usage frequently includes studies in which the materials are inoculated with bacteria in order to assess biofilm formation. Differences in the bacteria are considered to be due to the material alone; the


September 15, 2009
Sheng Lin-Gibson, Kaushik Chatterjee, James A. Cooper, William E. Wallace, Matthew Becker, Carl G. Simon Jr., Ferenc Horkay
A simple reaction to prepare controlled molecular mass (MM) poly(ethylene glycol) dimethacrylates (PEGDMs) of high purity and low polydispersity is outlined. PEGDMs were photo-polymerized to form hydrogels with and without bioactive moieties. The structure

Synthesis and Characterization of Elastin Mimetic Hybrid Polymers with Alternating Molecular Architecture and Elastomeric Properties

September 15, 2009
Sheng Lin-Gibson, Sarah E. Grieshaber, Alexandra J. Farran, Kristi L. Kiick, Xinqiao Jia
We are interested in developing elastin mimetic hybrid polymers (EMHPs) that capture the multiblock molecular architecture of tropoelastin as well as the remarkable elasticity of mature elastin. In this study, multiblock EMHPs containing flexible synthetic

Microbial colonization on polymers: Effects of sample preparation and incorporation of quaternary ammonium salts

September 13, 2009
Nancy J. Lin, Diana N. Zeiger, Joseph M. Antonucci, Bruce O. Fowler, Christopher M. Stafford, Sheng Lin-Gibson
Controlling bacterial growth in the oral environment presents many challenges. To address these challenges, new materials and treatments are needed along with controlled, reproducible methods to evaluate their efficacy. In this study, a reproducible method