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Displaying 176 - 200 of 2345

A complete reference genome improves analysis of human genetic variation

April 1, 2022
Author(s)
Sergey Aganezov, Stephanie Yan, Daniela Soto, Melanie Kirsche, Samantha Zarate, Justin Wagner, Jennifer McDaniel, Nathanael David Olson, Rajiv McCoy, Megan Dennis, Justin Zook, Michael Schatz
Compared to its predecessors, the Telomere-to-Telomere CHM13 genome adds nearly 200 million base pairs of sequence, corrects thousands of structural errors, and unlocks the most complex regions of the human genome for clinical and functional study. We show

Complete genomic and epigenetic maps of human centromeres

April 1, 2022
Author(s)
Nicolas Altemose, Glennis Logsdon, Andrey Bzikadze, Pragya Sidhwani, Sasha Langley, Gina Caldas, Justin Zook, Ivan Alexandrov, Karen Miga
Existing human genome assemblies have almost entirely excluded repetitive sequences within and near centromeres, limiting our understanding of their organization, evolution, and functions, which include facilitating proper chromosome segregation. Now, a

The complete sequence of a human genome

March 31, 2022
Author(s)
Sergey Nurk, Sergey Koren, Arang Rhie, Mikko Rautiainen, Jennifer McDaniel, Nathanael David Olson, Justin Wagner, Justin Zook, Evan Eichler, Karen Miga, Adam Phillippy
Since its initial release in 2000, the human reference genome has covered only the euchromatic fraction of the genome, leaving important heterochromatic regions unfinished. Addressing the remaining 8% of the genome, the Telomere-to-Telomere (T2T)

Federal Research Priorities to Support Wastewater Surveillance for SARS-CoV-2

March 30, 2022
Author(s)

Sally Gutierrez, Nancy Lin, Jessica Sweeney

Almost immediately after the start of the COVID-19 pandemic in 2020, researchers and wastewater utilities around the world began analyzing untreated wastewater for the SARS-CoV-2 RNA. These efforts were largely based on prior experience analyzing

Models for an Ultraviolet-C Research and Development Consortium

March 25, 2022
Author(s)
Dianne L. Poster, C Cameron Miller, Yaw S. Obeng, John J. Kasianowicz, Michael T. Postek, Norman Horn, Troy Cowan, Richard Martinello
The development of an international, precompetitive, collaborative, ultraviolet (UV) research consortium is discussed as an opportunity to lay the groundwork for a new UV commercial industry and the supply chain to support this industry. History has

The Structure of Lipids and Keratin in Adhesive Gecko Setae Determined by NEXAFS Imaging

March 1, 2022
Author(s)
Daniel A. Fischer, Cherno Jaye, Katinka R. Holler, Mette H. Rasmussen, Joe E. Baio, Stanislav N. Gorb, Tobias Weidner
Geckos have the astonishing ability to climb on vertical surfaces due to the adhesive properties of fibrous setae at the tips of their toe pads. While the adhesion mechanism principle, based on van-der-Waals interactions of myriads of spatula located at

Curated variation benchmarks for challenging medically relevant autosomal genes

February 7, 2022
Author(s)
Justin Wagner, Nathanael David Olson, Lindsay Harris, Jennifer McDaniel, Fritz Sedlazeck, Chen-Shan Chin, Justin Zook
The repetitive nature and complexity of some medically relevant genes poses a challenge for their accurate analysis in a clinical setting. The Genome in a Bottle Consortium has provided variant benchmark sets, but these exclude nearly 400 medically

Bioinspired Wear-Resistant and Ultra-Durable Functional Gradient Coatings

January 28, 2022
Author(s)
Zhengzhi Wang, Kun Wang, Houbing Huang, Xiao Cui, Zuoqi Zhang, Martin Chiang
For mechanically protective coatings, the coating material usually requires sufficient stiffness and strength to resist external forces and meanwhile matched mechanical properties with the underneath substrate to maintain the structural integrity. These
Displaying 176 - 200 of 2345