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Displaying 151 - 175 of 2345

Selective C-terminal Conjugation of Trypsin-Digested Peptides for Proteomic Measurements

July 20, 2022
Author(s)
Tian Xie, Alexandria Brady, Cecilia Velarde, David Vaccarello, Nicholas Callahan, John Marino, Sara Orski
Bottom-up proteomic experiments often require selective conjugation or labeling of the N- and/or C-termini of peptides either through bottom up approaches or selective post-cleavage functionalization of specific residues after proteolytic digestion . For

The need for multicomponent gas standards for breath biomarker analysis

July 7, 2022
Author(s)
Kavita Jeerage, Jennifer Berry, Jacolin Murray, Cassie Goodman, Paulina Piotrowski, Christina Jones, Christina Cecelski, Jennifer Carney, Katrice Lippa, Tara Lovestead
Exhaled breath is a non-invasive, information-rich matrix with the potential to diagnose or monitor disease, including infectious disease. Despite significant effort dedicated to biomarker identification in case control studies, very few breath tests are

Computational Study of the Allosteric Effects of p5 on the CDK5-p25 Hyperactivity as Alternative Inhibitory Mechanisms in Neurodegeneration

June 30, 2022
Author(s)
Tejaswi Tammareddy, Walid Keyrouz, Ram D. Sriram, Harish C. Pant, Antonio Cardone, Jeffery B. Klauda
The cyclin-dependent kinase (CDK5) forms a stable complex with its activator p25, leading to the hyperphosphorylation of tau proteins and to the formation of plaques and tangles that are considered to be one of the typical causes of Alzheimer's disease (AD

Evidence that gecko setae are coated with an ordered nanometer-thin lipid film

June 9, 2022
Author(s)
Cherno Jaye, Daniel A. Fischer, Mette Rasmussen, Katinka Holler, Joe Baio, Stanislav Gorb, Tobias Weidner
Motivated by the fascination of gecko adhesion based on the fibrous setae at the tips of their toe pads and their potential for biomimetic applications, the adhesion mechanism has been studied in detail. While the mechanism has been shown to be based on

Reference Material 8376 Microbial Pathogen DNA Standards for Detection and Identification

June 1, 2022
Author(s)
Jason Kralj, Dieter Tourlousse, Monique Hunter, Erica Romsos, Blaza Toman, Peter Vallone, Scott Jackson
Reference Material (RM) 8376 is intended for NGS-based measurements quantitative to the chromosome. A unit of RM 8376 consists of 20 components (A-T, 19 bacteria and 1 human) each containing well-characterized DNA in 10 mmol/L Tris-HCl, 1 mmol/L EDTA pH 8

Benchmarking challenging small variants with linked and long reads

May 11, 2022
Author(s)
Justin Wagner, Nathanael David Olson, Lindsay Harris, Marc L. Salit, Fritz Sedlazeck, Chunlin Xiao, Justin Zook
Genome in a Bottle benchmarks are widely used to help validate clinical sequencing pipelines and develop variant calling and sequencing methods. Here we use accurate linked and long reads to expand benchmarks in 7 samples to include difficult-to-map

Reference Materials for MS-based Untargeted Metabolomics and Lipidomics: A Review by the Metabolomics Quality Assurance and Quality Control Consortium (mQACC)

April 9, 2022
Author(s)
Katrice Lippa, William Davis, Christina Jones, Tracey Schock, Juan Aristizabal-Henao, Richard Beger, John Bowden, Corey Broeckling, Chris Beecher, Warwick Dunn, Roberto Flores, Goncalo Gouveia, Thomas Hartung, Matthew Lewis, Ioanna Ntai, Andrew Percy, Dan Raftery, Jinchun Sun, Georgios Theodoridis, Fariba Tayyari, Federico Torta, Candice Ulmer, Baljit Ubhi
Introduction The metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization and promotion of suitable reference materials (RMs) to be used in quality assurance (QA) and quality control
Displaying 151 - 175 of 2345