Deep Learning Image Analysis of Nanoplasmonic Sensors: Toward Medical Breath Monitoring

Published

November 23, 2022

Author(s)

Yangyang Zhao, Boqun Dong, Kurt D. Benkstein, Lei Chen, Kristen L. Steffens, Stephen Semancik

Abstract

Sensing biomarkers in exhaled breath offers a potentially portable, cost-effective, and noninvasive strategy for disease diagnosis screening and monitoring, while high sensitivity, wide sensing range, and target specificity are critical challenges. We demonstrate a deep learning-assisted plasmonic sensing platform that can detect and quantify gas-phase biomarkers in breath-related backgrounds of varying complexity. The sensing interface consisted of Au/SiO2 nanopillars covered with a 15 nm metal–organic framework. A small camera was utilized to capture the plasmonic sensing responses as images, which were subjected to deep learning signal processing. The approach has been demonstrated at a classification accuracy of 95 to 98% for the diabetic ketosis marker acetone within a concentration range of 0.5–80 μmol/mol. The reported work provides a thorough exploration of single-sensor capabilities and sets the basis for more advanced utilization of artificial intelligence in sensing applications.

Citation

ACS Applied Materials and Interfaces

Pub Type

Journals

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https://doi.org/10.1021/acsami.2c11153

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Keywords

plasmonic sensor, image analysis, neural networks, breath biomarker

Citation

Zhao, Y. , Dong, B. , Benkstein, K. , Chen, L. , Steffens, K. and Semancik, S. (2022), Deep Learning Image Analysis of Nanoplasmonic Sensors: Toward Medical Breath Monitoring, ACS Applied Materials and Interfaces, [online], https://doi.org/10.1021/acsami.2c11153, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=934442 (Accessed April 26, 2024)