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Biglycan regulates bone development and regeneration

Published

Author(s)

Reut Shainer, Vardit Kram, Tina Kilts, Andrew Doyle, Inbal Shainer, Carl Simon Jr., Jinyang Zeng-Brouwers, Liliana Schaefer, Marian Young

Abstract

Endochondral bone development and regeneration relies on activation and proliferation of periosteum derived cells (PDCs). Biglycan (Bgn), an extracellular matrix component, is known to be expressed in bone and cartilage, however little is known about its influence during bone development. Here we link Bgn with osteoblast maturation starting during embryonic development that with aging affects bone integrity and strength. Bgn gene deletion reduced the inflammatory response after fracture leading to impaired periosteum expansion and callus formation. Using a novel 3D scaffolds and analyzing newborn bones, we found that Bgn is required for the cartilage-bone transition of PDCs during endochondral bone development. The absence of Bgn led to accelerated bone development with high levels of osteopontin expression which appeared to be harmful to the structural integrity of the bone. Collectively, our study identifies Bgn as important factor in PDCs activation during bone development and bone regeneration after fracture.
Citation
https://www.cell.com/developmental-cell/home

Keywords

bone, biglycan, osteogenesis

Citation

Shainer, R. , Kram, V. , Kilts, T. , Doyle, A. , Shainer, I. , Simon Jr., C. , Zeng-Brouwers, J. , Schaefer, L. and Young, M. (2023), Biglycan regulates bone development and regeneration, https://www.cell.com/developmental-cell/home, [online], https://doi.org/10.3389/fphys.2023.1119368, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=933861 (Accessed April 23, 2024)
Created February 16, 2023, Updated September 5, 2023