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NIST Recommended Practice Guide: Fractography of Ceramics and Glasses, 3rd edition

September 14, 2020

Author(s)

George D. Quinn

Fractography is a powerful but underutilized tool for the analysis of fractured glasses and ceramics, for fractures in the laboratory and for component failures in service. Fractography can identify the cause of failure and can even provide quantitative

Defining the Cardiac Fibroblast Secretome in a Fibrotic Microenvironment

September 13, 2020

Author(s)

Tova Ceccato, Rachel Starbuck, Jessica Hall, Cierra Walker, Tobin E. Brown, Jason Killgore, Kristi S. Anseth, Leslie Leinwand

Using All-Atom Potentials to Refine RNA Structure Predictions of SARS-CoV-2 Stem Loops

August 27, 2020

Author(s)

Christina Bergonzo, Andrea L. Szakal

A considerable amount of rapid-paced research is underway to combat the SARS-CoV-2 11 pandemic. In this work, we assess the 3D structure of the 5' untranslated region of its RNA, in the 12 hopes that stable secondary structures can be targeted, interrupted

Tissue Engineering Measurands

August 26, 2020

Author(s)

Greta Babakhanova, Carl Simon Jr., Deepika Arora

A measurand is defined as the quantity that one intends to measure. As tissue engineering research translates into medical products, companies must prepare regulatory filings that contain many different types of measurement data that are collected about

Improving patient outcomes with regenerative medicine: How to move the needle forward in cell manufacturing, standards, 3D bioprinting, AI enabled automation, education and training

June 17, 2020

Author(s)

Carl Simon Jr., Josh Hunsberger, Claudia Zylberberg, Preveen Ramamoorthy, Thomas Tubon, Crystal Ruff, Ram Bedi, Kurt Gielen, Lynn Fisher, Jed Johnson, Priya Barankiak, Behzad Mahdavi, Michael Hadjisavas, Shannon Eaker, Cameron Miller

Regenerative Medicine Manufacturing Society (RMMS), is the first and only professional society dedicated specifically towards advancing manufacturing solutions for the field of regenerative medicine. RMMS' vision is to provide greater patient access to

A Tool to Model the Fate and Transport of Indoor Microbiological Aerosols (FaTIMA)

June 1, 2020

Author(s)

William S. Dols, Brian J. Polidoro, Dustin G. Poppendieck, Steven J. Emmerich

The web-based tool Fate and Transport of Indoor Microbiological Aerosols (FaTIMA) allows for the determination of the indoor fate of microbiological aerosols associated with ventilation, filtration, deposition and inactivation mechanisms. FaTIMA provides a

Workshop on the Characterization of Fiber-Based Scaffolds: Where We Are and What We Need to Move Forward

May 12, 2020

Author(s)

Carl Simon Jr., Becky Robinson-Zeigler, Michael Yaszemski, Jayesh Doshi, Michael Francis, Sherif Soliman, Lexi Garcia

As the tissue engineering and regenerative medicine (TERM) industry transitions from small-scale development of prototypes for research and design purposes to large-scale production for the clinic there is a need to ensure that products are properly

Photo-tunable hydrogel mechanical heterogeneity informed by predictive transport kinetics model

May 6, 2020

Author(s)

Callie I. Higgins, Jason P. Killgore, Frank W. DelRio, Stephanie J. Bryant, Robert R. McLeod

Mimicking the three-dimensional (3D) mechanical and chemical properties of distinctly different, adjacent biological tissues is crucial to study and to understand these regions. 3D printing is a technique often employed to spatially control the

Role of Standards for Testing and Performance Requirements of Biomaterials

May 5, 2020

Author(s)

Carl Simon Jr., Liisa Kuhn

Chemometric Outlier Classification of 2D-NMR Spectra to Enable Higher Order Structure Characterization of Protein Therapeutics

April 15, 2020

Author(s)

David Sheen, Vincent K. Shen, Robert G. Brinson, Luke Arbogast, John Marino, Frank Delaglio

Protein therapeutics are vitally important clinically and commercially, with monoclonal antibody (mAb) therapeutic sales alone accounting for $115 billion in revenue for 2018.[1] In order for these therapeutics to be safe and efficacious, their protein

Quantitative Bright-Field Microscopy Combined with Deep Neural Networks Predict Live Tissue Function

February 29, 2020

Author(s)

Carl Simon Jr., Nicholas J. Schaub, Petru S. Manescu, Sarala Padi, Mylene Simon, Peter Bajcsy, Nathan A. Hotaling, Joe Chalfoun, Mohamed Ouladi, Qin Wan, Kapil Bharti, Ruchi Sharma

Progressive increases in the number of cell therapies in the preclinical and clinical phases has prompted the need for reliable and non-invasive assays to validate transplant function in clinical biomanufacturing. Here, we developed a robust

Certification of Standard Reference Material(R) 2925: Recombinant Human Serum Albumin Solution (Primary Reference Calibrator for Urine Albumin) (Frozen)

February 19, 2020

Author(s)

Ashley B. Green, David M. Bunk, Nien F. Zhang, Wendell Alejo

This Standard Reference Material (SRM) is intended primarily for use in the preparation of calibration solutions for a candidate reference measurement procedure for human serum albumin (HSA) in human urine. This candidate reference measurement procedure is

CELL-FREE (Comparable Engineered Living Lysates for Research Education and Entrepreneurship) Workshop Report

February 13, 2020

Author(s)

Elizabeth A. Strychalski, Eugenia F. Romantseva

The CELL-FREE Workshop sought to identify and prioritize actionable steps towards more reproducible and comparable cell-free systems for practical applications in bioengineering and biomanufacturing.

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