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NIST Authors in Bold

Displaying 17301 - 17325 of 73885

QconCAT: Internal Standard for Protein Quantification

October 21, 2015
Author(s)
Kerry M. Bauer, Karen W. Phinney, Illarion V. Turko
Protein quantification based on stable-isotope labeling mass spectrometry (SIL-MS) involves adding known quantities of stable-isotope labeled internal standards into biological samples. The internal standards are analogous to analyte molecules and

Tomography of photon-number resolving continuous-output detectors

October 21, 2015
Author(s)
Thomas Gerrits, Peter C. Humphreys, Benjamin Metcalf, Thomas Hiemstra, Adriana E. Lita, Sae Woo Nam, Animesh Datta, Steven Kolthammer, Ian Walmsley, Joshua Nunn
We develop a comprehensive approach to analyzing the continuous output of photon detectors. It uses principle component analysis to extract information available from such detectors, followed by a novel parameterized photon-number resolving detector

A LEGO Watt Balance, An apparatus to demonstrate the definition of mass based on the new SI

October 20, 2015
Author(s)
Leon S. Chao, Stephan Schlamminger, David B. Newell, Jon R. Pratt, Georgio A. Sineriz, Frank C. Seifert, Darine El Haddad, Yusi A. Cao, Xiang Zhang
A redefinition of our system of units, the SI, is currently being discussed and its implementation is expected in 2018. With the redefinition, the current base units will no longer be required and all units henceforth will be based upon fixed values of

The JAR Extractor: a Soxhlet Modified Into a Large-Diameter Wafer Washer

October 20, 2015
Author(s)
Richard J. Sheridan, Aaron V. Kirchhoff
A closed-atmosphere, solvent-recirculating, large diameter wafer washer was fabricated for neutron reflectivity research at the National Institute of Standards and Technology. Manufacturing feasibility for the public sector was increased by simplicity in

Applied Strain on Sealant Samples Exposed to Outdoor Weather

October 19, 2015
Author(s)
Christopher C. White, Donald L. Hunston, Kar tean Tan
In outdoor exposures used to establish durability of sealant formulations, applied strain is typically absent. It is a critical aspect of the in-service environment. This research employs two recently available techniques to examine how the presence of

Electronic Enhancement of the Exciton Coherence Time in Charged Quantum Dots

October 19, 2015
Author(s)
Galan A. Moody, Corey A. McDonald, Ari D. Feldman, Todd E. Harvey, Richard P. Mirin, Kevin L. Silverman
Minimizing decoherence due to coupling of a quantum system to its fluctuating environment is at the forefront of quantum information and photonics research. Nature sets the ultimate limit, however, given by the strength of the system’s coupling to the

Protection of Controlled Unclassified Information

October 19, 2015
Author(s)
Ronald S. Ross, Kelley L. Dempsey, Larry Feldman, Gregory A. Witte
This bulletin summarizes the information presented in NIST SP 800-171: Protecting Controlled Unclassified Information in Nonfederal Information Systems and Organizations. The publication the protection of Controlled Unclassified Information (CUI) while

The NIST IAD Data Science Research Program

October 19, 2015
Author(s)
Bonnie J. Dorr, Peter C. Fontana, Craig S. Greenberg, Mark A. Przybocki, Marion Le Bras, Cathryn A. Ploehn, Oleg Aulov, Martial Michel, Edmond J. Golden III, Wo L. Chang
We examine foundational issues in data science including current challenges, basic research questions, and expected advances, as the basis for a new Data Science Research Program and evaluation series, introduced by the Information Access Division of the

Optical-to-RF Frequency Synthesis: Application Priorities for Ultra-low Phase Noise

October 18, 2015
Author(s)
David A. Howe, Archita Hati, Craig W. Nelson, Lora L. Nugent-Glandorf
We describe operational challenges and progress of optical frequency-comb dividers (OFDs) that synthesize RF signals from the optical domain. Our priorities include: (1) ultra-low phase-noise, (2) continuous operation, and (3) broadly low Allan deviation.

Equilibrium Self-Assembly, Structure, and Dynamics of Clusters of Star-Like Micelles

October 17, 2015
Author(s)
Vivek M. Prabhu, Shrinivas Venkataraman, Yi Yan Yang, James Hedrick
Small-angle neutron scattering and static and dynamic light scattering have characterized the hierar-chical structure and dynamics of clusters of self-assembled star-like micelles formed by oligocarbonate-fluorene func-tionalized polyethylene glycol

NIST on a Chip: Realizing SI units with microfabricated alkali vapour cells

October 16, 2015
Author(s)
John E. Kitching, Elizabeth A. Donley, Svenja A. Knappe, Matthew T. Hummon, Argyrios Dellis, Jeffrey A. Sherman, Kartik A. Srinivasan, Vladimir A. Aksyuk, Qiliang Li, Daron A. Westly, Brian J. Roxworthy, Amit Lal
We describe several ways in which microfabricated alkali atom vapour cells might potentially be used to accurately realize a variety of SI units, including the second, the meter, the kelvin, the ampere and the volt, in a compact, low-cost “chip-scale”

Quantifying Trace 2,4,6-Trinitrotoluene (TNT) in Polymer Microspheres

October 16, 2015
Author(s)
Timothy M. Brewer, Robert A. Fletcher, Matthew E. Staymates
Well characterized test materials are essential for validating the performance of current trace explosive detection systems. Explosive encapsulated microspheres have proven to be a valuable test material for trace explosive detection because their precise

A Single-Pixel Touchless Laser Tracker Probe

October 15, 2015
Author(s)
Josh Gordon, David R. Novotny, Alexandra Curtin
We have developed a laser tracker probe, the Pixel Probe, that does not require physically contacting the object one is measuring and which has 3D spatial resolution of about 25 μm (in x,y,z) in the current configuration. This touchless laser tracker probe

Abiotic bromination of soil organic matter

October 15, 2015
Author(s)
Bruce D. Ravel, Alessandra C. Leri
Biogeochemical transformations of plant-derived soil organic matter (SOM) involve complex abiotic and microbially mediated reactions. One such reaction is halogenation, which occurs naturally in the soil environment and has been associated with enzymatic

Confidence Estimation in Stem Cell Classification

October 15, 2015
Author(s)
Peter Bajcsy, Jana Kosecka, Zahra Rajabi
We study the problem of supervised classification of stem cell colonies and confidence estimation of the attained classification labels. The problem is investigated in the application context of heterogeneity labels of stem cell colonies observed by using

Current and Emerging Technologies to Characterize the Higher-Order Structure of Monoclonal Antibodies

October 15, 2015
Author(s)
John Marino, Robert G. Brinson, Jane E. Ladner, David Travis Gallagher, Luke Arbogast, Richard Huang, Jeffrey W. Hudgens, Elyssia S. Gallagher
In contrast to small molecule therapeutics whose conformations can be absolutely defined by constitution and stereochemistry, biopharmaceuticals are distinguished by the requirement for folding into higher order structures (secondary, tertiary, and

Determination of the Primary Sequence/ Structure

October 15, 2015
Author(s)
Catherine A. Mouchahoir, Mellisa Ly, Michaella Levy, Lisa E. Kilpatrick, Scott C. Lute, Karen W. Phinney, Lisa Marzilli, Kurt A. Brorson, Michael T. Boyne, Darryl Davis, John E. Schiel
The primary sequence of a protein, including therapeutic monoclonal antibodies (mAbs), is a critical quality attribute that determines a great deal of its functionality and stability. Significant effort is devoted to determining the complete amino acid

Glycan Analysis of NIST mAb Reference Material

October 15, 2015
Author(s)
John E. Schiel, Catherine A. Mouchahoir
N-linked glycosylation is a common post-translational modification that imparts structural heterogeneity to recombinant monoclonal antibody therapeutics. The various oligosaccharides attached to the CH2 domains of IgG can impact the efficacy, safety and
Displaying 17301 - 17325 of 73885
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