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Displaying 176 - 200 of 861

An updated protocol based on CLSI document C37 for preparation of off-the-clot serum from individual units for use alone or to prepare commutable pooled serum reference materials

October 30, 2019
Author(s)
Johanna Camara, Uliana Danilenko, Hubert W. Vesper, Gary L. Myers, Patric A. Clapshaw, W. Greg Miller
Manufacturers of in-vitro diagnostic medical devices, clinical laboratories, research laboratories and calibration laboratories require commutable reference materials that can be used in the calibration hierarchies of medical laboratory measurement

Primary standardization of Ra-224 activity by liquid scintillation counting

October 11, 2019
Author(s)
Denis E. Bergeron, Jeffrey T. Cessna, Ryan P. Fitzgerald, Brian E. Zimmerman, Lizbeth Laureano-Perez, Ronald Colle, Leticia S. Pibida, Elisa Napoli
A standard for 224Ra activity has been developed, based on triple-to-double coincidence ratio (TDCR) liquid scintillation (LS) counting. The standard was confirmed by efficiency tracing and 4παβ(LS)-γ(NaI(Tl)) anticoincidence counting, as well as by 4πγ

NIST Fatty Acid Quality Assurance Program 2017 Final Report

October 1, 2019
Author(s)
Bruce A. Benner Jr., Jacolin A. Murray
At the request of the National Institutes of Health’s (NIH’s) Office of Dietary Supplements (ODS) and in conjunction with the Centers for Disease Control and Prevention (CDC), in 2017 the National Institute of Standards and Technology (NIST) conducted the

Mass Spectrometry Fingerprints of Small-Molecule Metabolites in Biofluids: Building a Spectral Library of Recurrent Spectra for Urine Analysis

August 18, 2019
Author(s)
Yamil Simon, Ramesh Marupaka, Xinjian Yan, Yuxue Liang, Kelly H. Telu, Yuri Mirokhin, Stephen E. Stein
A large fraction of ions observed in electrospray liquid chromatography–mass spectrometry (LC–ESI-MS) experiments of biological samples remain unidentified. One of the main reasons for this is that spectral libraries of pure compounds fail to account for

Standardization of I-124 by three liquid scintillation-based methods

August 9, 2019
Author(s)
Denis E. Bergeron, Leticia S. Pibida, Brian E. Zimmerman, Jeffrey T. Cessna, Ryan P. Fitzgerald
A solution of 124I was standardized for activity by 4πβ(LS)-γ(NaI) live-timed anticoincidence (LTAC) counting, with confirmatory measurements by triple-to-double coincidence ratio (TDCR) and CIEMAT-NIST efficiency tracing (CNET) liquid scintillation

Workshop 9: Control Cells or Not

June 17, 2019
Author(s)
Paul Wallace, Jonni S. Moore, Derek Jones, Litwin Virginia, Lili Wang, Yanli Liu
"Control Cells or Not" was an educational workshop that used surveys, lectures, and discussions to identify problems and solutions related to using commercially available control cell products and lab-developed approaches. Collective efforts are proposed

High-coverage, long-read sequencing of Chinese trio reference samples

June 14, 2019
Author(s)
Justin M. Zook, Nathanael D. Olson, Marc L. Salit, Aaron Wenger, Chunlin Xiao, Robert Sebra
Genome In a Bottle (GIAB) is a consortium hosted by the National Institute of Standards and Technology whose primary objective is the development and characterization of human genomic reference materials. The consortium includes representatives from

Structure and Function in Antimicrobial Piscidins: Histidine Position, Directionality of Membrane Insertion, and pH-Dependent Permeabilization

May 30, 2019
Author(s)
Ella Mihailescu, Mirco Sorci, Jolita Seckute, Vitalii I. Silin, Janet Hammer, B. Scott Perrin, Jorge Hernandez, Nedzada Smajic, Akritee Shrestha, Kimberly Bogadardus, Alexander Greenwood, Riqiang Fu, Jack Blazyk, Richard W. Pastor, Linda Nicholson, Georges Belfort, Myriam Cotten
Piscidins are histidine-enriched antimicrobial peptides that interact with lipid bilayers as amphipathic alpha-helices. Their activity at acidic and basic pH in vivo makes them promising templates for biomedical applications. This study focuses on p1 and

Characterization of Rare NEIL1 Variants Found in East Asian Populations

May 3, 2019
Author(s)
Irina G. Minko, Vladimir Vartanian, Naoto Tozaki, Oskar Linde, Pawel Jaruga, Sanem Hosbas Coskun, Erdem Coskun, Chunfeng Qu, Huan He, Taoyang Chen, Qianqian Song, Yuchen Jiao, Michael Stone, Martin Egli, Miral M. Dizdar, Amanda K. McCullough, R S. Lloyd
The combination of chronic dietary exposure to the fungal toxin, aflatoxin B1 (AFB1), and hepatitis B viral (HBV) infection is associated with an increased risk for early onset hepatocellular carcinomas (HCCs). An in-depth knowledge of the mechanisms

Identification and quantification of DNA repair protein poly(ADP ribose) polymerase 1 (PARP1) in human tissues and cultured cells by liquid chromatography/isotope-dilution tandem mass spectrometry

March 1, 2019
Author(s)
Erdem Coskun, Gamze Tuna, Pawel Jaruga, Alessandro Tona, Onur Erdem, M Miral Dizdar
Poly(ADP ribose) polymerase 1 (PARP1) is a multifunctional DNA repair protein of the base excision repair pathway and plays a major role in the repair of DNA strand breaks and in replication and transcriptional regulation among other functions. Mounting

NIST Micronutrients Measurement Quality Assurance Program: 1984-1985 Comparability Studies Results for Round Robins I, II, III and V Fat Soluble Vitamins and Carotenoids in Human Serum

February 8, 2019
Author(s)
Jeanice M. Brown Thomas, David L. Duewer, Margaret C. Kline, William A. MacCrehan, Robert Paule, Reenie Parris, Willie May, Robert Schaffer
From 1984 to 2017, the National Institute of Standards and Technology (NIST) and its precursor the National Burearu of Standards (NBS) coordinated what became the Micronutrients Measurement Quality Assurance Program (MMQAP) for laboratories that measure

CrowdVariant: a crowdsourcing approach to curate copy number variants

January 6, 2019
Author(s)
Justin M. Zook, Marc L. Salit, Peyton Greenside, Ryan Poplin, Mark DePristo, Madeleine Cule
Copy number variants (CNVs) are an important type of genetic variation and play a causal role in many diseases. However, they are also notoriously difficult to identify accurately from next-generation sequencing (NGS) data. For larger CNVs, genotyping

Report from the Winter Mid-Atlantic Microbiome Meet-up on Biodefense and Pathogen Detection, College Park, MD January 10th, 2018

November 5, 2018
Author(s)
Jacquelyn S. Meisel, Daniel Nasko, Brian Brubach, Victoria Cepeda Espinoza, Jessica Chopyk, Hector Corrada Bravo, Marcus Fedarko, Jay Ghurye, Kiran Javkar, Nathan D. Olson, Nidhi Shah, Sarah M. Allard, Adam L. Bazinet, Nichloas H. Bergman, Alexis Brown, Greg Caporaso, Sean Conlan, Jocelyn DiRuggiero, Samuel Forry, Nur A. Hasan, John Julias, Paul M. Luethy, Donald K. Milton, Brian Ondov, Sarah Preheim, Tara O'Toole, Stephanie Rogers, M.J. Rosovitz, Eric G. Sakowski, Nils O. Schliebs, Daniel D. Sommer, Krista Ternus, German Uritskiy, Sean X. Zhang, Mihai Pop, Todd Treangen
The Mid-Atlantic Microbiome Meet-up (M3) organization held its fourth meeting on January 10, 2018 in College Park, Maryland. M3 brings together academic, government, and industry groups in the broadly-defined mid-Atlantic region to share ideas and develop

Effects of Consumer Use Practices on Nanosilver Release from Commercially Available Food Contact Materials

October 23, 2018
Author(s)
Susana Addo Ntim, Samuel R. Norris, David Goodwin, Jens Breffke, Keana Scott, Li Piin Sung, Treye Thomas, Gregory O. Noonan
Migration evaluation involving nano-enabled food contact materials (FCMs) mostly focus on potential nanoparticle release from new unused products. This may not represent consumer use practices encountered by the FCMs in their lifecycle. In order to

Innovative Approaches to Combat Healthcare-Associated Infections Using Efficacy Standards Developed Through Industry and Federal Collaboration

October 5, 2018
Author(s)
Dianne L. Poster, Carl C. Miller, Yaw S. Obeng, Michael T. Postek, Troy E. Cowan, Richard A. Martinello
Nation-wide, healthcare-associated infections (HAIs) infect one in every 25 hospital patients, account for more than 100,000 deaths and increase medical costs by around $96-147B, each year. Ultraviolet-C (UV-C) antimicrobial devices are shown to reduce the

Combinatorial Cassettes for Higher-Throughput Screening of Osteogenesis

October 4, 2018
Author(s)
Carl G. Simon Jr., Subhadip Bodhak, Hariharan K. Iyer, Luis Fernandez de Castro Diaz, Pam Robey, Azusa Maeda, Sergei Kuznetsov
Animal models are the most biologically relevant method for measuring the osteogenic capability of bone graft formulations. However, animal experiments are slow, tedious and the results can be highly variable, even when conducted within the same lab. In

Simmering Sauces! Elevated Formaldehyde Concentrations from Gas Stove Burners

July 22, 2018
Author(s)
Dustin G. Poppendieck, Mengyan Gong
Formaldehyde is listed as a human carcinogen, and can be formed as a primary by-product during combustion processes. Past studies have not detected elevated formaldehyde concentrations from gas stoves, perhaps due to the time averaging nature of previous

An update on dose calibrator settings for nuclides used in nuclear medicine

June 1, 2018
Author(s)
Denis E. Bergeron, Jeffrey T. Cessna
Most clinical measurements of radioactivity, whether for therapeutic or imaging nuclides, rely on commercial reentrant ionization chambers (“dose calibrators”). The National Institute of Standards and Technology (NIST) maintains a battery of representative

Standardization of 64Cu activity

May 25, 2018
Author(s)
Denis E. Bergeron, Jeffrey T. Cessna, Ryan P. Fitzgerald, Leticia S. Pibida, Brian E. Zimmerman
The complex decay scheme that makes 64Cu promising as both an imaging and therapeutic agent in medicine also makes the absolute measurement of its activity challenging. The National Institute of Standards and Technology (NIST) has completed a primary

NIST Micronutrients Measurement Quality Assurance Program: Spring and Fall 1987 Comparability Studies-Results for Round Robins IX and XI Fat-Soluble Vitamins and Carotenoids in Human Serum

May 21, 2018
Author(s)
Jeanice M. Brown Thomas, David L. Duewer, Margaret C. Kline, Willie May, Emil Schonberger
From 1984 to 2017, the National Institute of Standards and Technology coordinated the Micronutrients Measurement Quality Assurance Program (MMQAP) for laboratories that measure fat- soluble vitamins and carotenoids in human serum and plasma. This report

Opportunities and Challenges in Implementation of Multiparameter Single Cell Analysis Platforms for Clinical Translation

May 11, 2018
Author(s)
susan M. Keating, D. Lansing Taylor, Anne L. Plant, E. David Litwack, Peter Kuhn, Emily J. Greenspan, Christopher M. Hartshorn, Caroline C. Sigman, Gary J. Kelloff, Gregory Friberg, Jerry S. Lee, Keisuke Kuida
The high-content interrogation of single cells with platforms optimized for the multiparameter characterization of cells in liquid and solid biopsy samples can enable characterization of heterogeneous populations of cells ex vivo. Doing so will advance the

Oxidatively-induced DNA damage and base excision repair in euthymic patients with bipolar disorder

May 1, 2018
Author(s)
Deniz Ceylan, Gamze Tuna, Guldal Kirkali, Zeliha Tunca, Gunes Can, Hidayet E. Arat, Melis Kant, Miral M. Dizdar, Aysegul Ozerdem
Oxidatively-induced DNA damage has previously been associated with bipolar disorder. More recently, impairments in DNA repair mechanisms have also been reported. We aimed to investigate oxidatively-induced DNA lesions and expression of DNA glycosylases
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