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Claire Dessalles, Nicolas Cuny, Arthur Boutillon, Paul Salipante, Avin Babataheri, Abdul Barakat, Guillaume Salbreux
Blood vessels expand and contract actively, while continuously experiencing dynamic external stresses from the blood flow. The mechanical response of the vessel wall is that of a composite material: its mechanical properties depend on its cellular
Eun Jin Lee, Peter Lialios, Micaila Curtis, James Williams IV, Yoontae Kim, Paul Salipante, Steven Hudson, Mandy Esch, moshe levi, Joanna Kitlinska, Stella Alimperti
Glucocorticoids (GCs) are standard-of-care treatments for inflammatory and immune disorders, and their long-term use increases the risk of osteoporosis. Although GCs decrease bone functionality, their role in bone microvasculature is incompletely
Abhishek Dhand, Matthew Davidson, Hannah Zlotnick, Thomas Kolibaba, Jason Killgore, Jason Burdick
Incorporation of polymer chain entanglements within a single network can synergistically improve stiffness and toughness, yet attaining such dense entanglements through vat photopolymerization additive manufacturing (e.g., digital light processing, DLP)
Safa Hameed, Navin Viswakarma, Eliyas Siddiqui, Greta Babakhanova, Carl Simon Jr., Boris Epel, Mrignayani Kotecha
Cell viability is an essential measurement for cell therapy, tissue engineered medical products (TEMPs), drug development, and many other biological processes and products. These systems rely on viable, healthy, and functional cells to work as intended
Greta Babakhanova, Carl Simon Jr., Eugenia Romantseva
Biofabricated tissue-engineered constructs have the potential to transform personalized medicine. However, characterizing these constructs post-fabrication and throughout preclinical use remains challenging. On December 1, 2022, the National Institute of
Carl Simon Jr., Anne L. Plant, Catherine Zander, Erich Bozenhardt, Christina Celluzzi, David Dobnik, Melanie Grant, John Hughes, Uma Lakshmipathy, Kok-Seong Lim, Laura Montgomery, Hesham Nawar, Thiana Nebel, Linda Peltier, James Sherley, Rouzbeh Taghizadeh, Eddie Tan, Sandrine Vessillier
One of the most challenging aspects of cell and gene therapy products (CGTPs) is defining mechanism of action (MOA), potency and efficacy of the product. This perspective examines these concepts and presents helpful ways to think about them through the
Polyorganophosphazenes are water-soluble macromolecules with immunoadjuvant activity that self-assemble with proteins to enable biological functionality. Direct imaging by cryogenic electron microscopy uncovers the coil structure of those highly charged
Taeho Yang, Yong Sik Kim, Joonyong Chang, Nicholas G. Dagalakis
Bio-simulants and finite element (FE) models have been used to investigate internal injuries caused by external impacts. As the collaboration between humans and industrial robots increases, it is important to understand the expected injuries or damage
Luke Summey, Jing Zhang, Alexander Landauer, Jamie Sergay, Jin Yang, Annalise Daul, Jialiang Tao, Jessica Park, Christian Franck
Background: Intermediate-strain-rate mechanical testing of soft and biological materials is important when designing, measuring, predicting, or manipulating an object or system's response to common impact scenarios. Open source micro-mechanical testing
Jacob Pawlik, Nick Barrera, Ellis Meng, Jim Booth, Chris Long, Nate Orloff, Eugene Yoon, Angela Stelson
Parylene C is a widely used dielectric barrier in implantable medical devices because it conforms well to surfaces and insulates against biological environments. However, multiple studies have shown that moisture can intrude into Parylene C films through
Jeremiah Woodcock, Douglas M. Fox, Ilabahen A. Patel, Joy Dunkers, Stephan J. Stranick, Jeffrey W. Gilman
Typical studies of gastral toxicity are conducted using radio labeling. This tends to be quite expensive and difficult owing to the required protocols for working with these materials and the expense of the chemical reagents. A possible alternative is
Carl Simon Jr., Smitha Rao, James Dolgin, Stephen Farias, Samerender Hanumantharao
Electrospinning is a versatile tool used to produce highly customizable nonwoven nanofiber mats of various fiber diameters, pore sizes, and alignment. It is possible to create electrospun mats from synthetic polymers, biobased polymers, and combinations
Michael Lueckheide, Alexander Marin, Harichandra Tagad, Nicholas Posey, Vivek Prabhu, Alexander Andrianov
Polyphosphazenes represent a class of intrinsically flexible polyelectrolytes with potent immunoadjuvant activity, which is enabled through non-covalent self-assembly with antigenic proteins by charge complexation. The formation of supramolecular complexes
Greta Babakhanova, Anant Agrawal, Deepika Arora, Allison Horenberg, Jagat Budhathoki, Joy Dunkers, Joe Chalfoun, Peter Bajcsy, Carl Simon Jr.
In the field of tissue engineering, 3D scaffolds and cells are often combined to yield constructs that are used as therapeutics to repair or restore tissue function in patients. Viable cells are required to achieve the intended mechanism of action for the
Carl Simon Jr., Peter Bajcsy, Joe Chalfoun, Michael Paul Majurski, Mary C. Brady, Mylene Simon, Nathan Hotaling, Nick Schaub, Allison Horenberg, Piotr Szczypinski, Dongbo Wang, Veronica DeFelice, Soweon Yoon, Stephanie Florczyk
The properties and structure of the cellular microenvironment can influence cell behavior. Sites of cell adhesion to the extracellular matrix (ECM) initiate intracellular signaling that direct cell functions such as proliferation, differentiation and
We establish here a set of cytocentric principles to improve use of cells for regenerative medicine (RM) applications. The five cytocentric principles are cells need 1) full-time protection from contamination, 2) physiologic simulation, 3) proper
Selda Buyukozturk, Alexander Landauer, Jing Zhang, Luke Summey, Angel Chukwu, Christian Franck
Background: High strain-rate deformations of soft materials have several applications which presents an experimental need to measure at-rate 3D volumetric spatial information. While 2D- and 3D-digital image correlation, digital volume correlation, and
Aaron Goldfain, Paul Lemaillet, David W. Allen, Kimberly Briggman, Jeeseong C. Hwang
We report on techniques to manufacture and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Tunability of the absorption (a()) and reduced scattering spectra (s'()) in the wavelength range of 500 nm to 850 nm is
For hydrogen-deuterium exchange mass spectrometry (HDX-MS) to have an increased role in quality control of biopharmaceuticals, H for D back-exchange occurring during protein analyses should be minimized to promote greater reproducibility. Standard HDX-MS
Yoontae Kim, Eun Jin Lee, Anthony Kotula, Shozo Takagi, Laurence C. Chow, Styliani Alimperti
Bone grafting is a surgical procedure to bone repair due to trauma or diseases in the craniofacial and dental area. Current limitations of autogenous and allogeneic grafts are often associated with reduced host-graft integration due to geometrical confor
Katrice Lippa, William Davis, Christina Jones, Tracey Johnston, Juan Aristizabal-Henao, Richard Beger, John Bowden, Corey Broeckling, Chris Beecher, Warwick Dunn, Roberto Flores, Goncalo Gouveia, Thomas Hartung, Matthew Lewis, Ioanna Ntai, Andrew Percy, Dan Raftery, Jinchun Sun, Georgios Theodoridis, Fariba Tayyari, Federico Torta, Candice Ulmer, Baljit Ubhi
Introduction The metabolomics quality assurance and quality control consortium (mQACC) is enabling the identification, development, prioritization and promotion of suitable reference materials (RMs) to be used in quality assurance (QA) and quality control
Daniel Fischer, Cherno Jaye, Katinka R. Holler, Mette H. Rasmussen, Joe E. Baio, Stanislav N. Gorb, Tobias Weidner
Geckos have the astonishing ability to climb on vertical surfaces due to the adhesive properties of fibrous setae at the tips of their toe pads. While the adhesion mechanism principle, based on van-der-Waals interactions of myriads of spatula located at