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Bioscience

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Displaying 751 - 775 of 1261

Modulus-Driven Differentiation of Marrow Stromal Cells in 3D Is Independent of Cytoskeletal Integrity

April 11, 2011
Author(s)
Carl G. Simon Jr., Kaushik Chatterjee, Sapun Parekh, Sheng Lin-Gibson, Nicole M. Moore, Marcus T. Cicerone, Marian F. Young
Cell functions such as proliferation, migration, and differentiation are key physiological processes that are influenced by the physiochemical extracellular environment. We report on the effect of three-dimensional (3D) scaffold modulus on human bone

Recent Advances in Electrochemical Glyco-biosensing

April 8, 2011
Author(s)
Rebecca A. Zangmeister, Germarie Sanchez-Pomales
Biosensors based on electrochemical transduction mechanisms have recently made advances into the field of glycan analysis. These glyco-biosensor assays offer simple, rapid, sensitive and economical approaches to the measurement need for rapid glycan

Quantification and Compensation of Unintentional Analyte Aggregation in Electrospray Sampling

March 30, 2011
Author(s)
Mingdong M. Li, Suvajyoti S. Guha, Rebecca A. Zangmeister, Michael J. Tarlov, Michael R. Zachariah
Electrospray (ES) sources are commonly used to introduce non-volatile materials (e.g. nanoparticles, proteins, etc.) in to the gas phase for characterization by mass spectrometry and ion mobility. Recent studies in our group using electrospray ion mobility

Characterization of Hyperspectral Imaging and Analysis via Microarray Printing of Dyes

February 22, 2011
Author(s)
Matthew L. Clarke, Maritoni A. Litorja, David W. Allen, Daniel V. Samarov, Jeeseong Hwang
The application of hyperspectral imaging requires rigorous characterization of the spatial and spectral imaging domains of the system. We present a microarray printing methodology for the testing of absorption or reflectance microscopy measurements. This

NMR Characterization of the Formation Kinetics and Structure of Di-O-Benzylidene Sorbitol Gels Self-Assembled in Organic Solvents

January 19, 2011
Author(s)
David L. VanderHart, Jack F. Douglas, Steven Hudson, Joseph M. Antonucci, Elizabeth A. Wilder
The molecule 1,3:2,4-Di-O-Benzylidene sorbitol (DBS) is a common gelator that forms thermally reversible gels in diverse organic solvents. Solid state 13C and proton NMR techniques, along with electron microscopy, are utilized in an exploratory study of

Detection of Heteroplasmic Mitochondrial DNA in Single Mitochondria

December 17, 2010
Author(s)
Joseph E. Reiner, Rani Kishore, Barbara C. Levin, Thomas Albanetti, Nicholas Boire, Ashley Knipe, Kristian Helmerson, Koren Deckman
Background Mitochondrial DNA (mtDNA) genome mutations can lead to energy and respiratory-related disorders like myoclonic epilepsy with ragged red fiber disease (MERRF), mitochondrial myopathy, encephalopathy, lactic acidosis and stroke (MELAS) syndrome

Predicting Segmentation Accuracy for Biological Cell Images

December 15, 2010
Author(s)
Adele P. Peskin, Alden A. Dima, Joe Chalfoun, John T. Elliott
We have performed segmentation procedures on a large number of images from two mammalian cell lines that were seeded at low density, in order to study trends in the segmentation results and make predictions about cellular features that affect segmentation

Predicting Segmentation Accuracy for Biological Cell Images

November 29, 2010
Author(s)
Adele P. Peskin, Alden A. Dima, Joe Chalfoun
We have performed image segmentations on a very large number of images, using a wide variety of imaging conditions and cell lines, in order to study trends in the segmentation results and make predictions about segmentation accuracy. Comparing results from

A Human Inspired Local Ratio-Based Algorithm for Edge Detection in Fluorescent Cell Images

November 25, 2010
Author(s)
Adele P. Peskin, Joe Chalfoun, Alden A. Dima, John T. Elliott, James J. Filliben
We have developed a new semi-automated method for segmenting images of biological cells seeded at low density on tissue culture substrates, which we use to improve the generation of reference data for the evaluation of automated segmentation algorithms

Effect of 3D Hydrogel Scaffold Stiffness on Human Bone Marrow Stromal Cell Differentiation

November 1, 2010
Author(s)
Carl G. Simon Jr., Sapun Parekh, Marcus T. Cicerone, Sheng Lin-Gibson, Kaushik Chatterjee, Marian F. Young
There is growing recognition cells can sense and respond to the mechanical properties of tissue scaffolds and that these interactions are critical in optimizing scaffold design [1-4]. Previous studies in planar 2D culture format have shown that human bone
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