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Megan Cleveland (Fed)

Research Biologist

Megan received her Ph.D. in Human Genetics and Molecular Biology from Johns Hopkins in December of 2014.  For her Ph.D. project, she performed a systematic survey (using exon arrays) of transcription factor expression during mouse pancreas development (as a function of developmental stage and tissue localization).  This resulted in the identification of two differentially expressed transcription factors potentially driving early pancreas differentiation.  

In her work at NIST, Megan will be developing clinical standards related to genetic testing techniques such as digital PCR and next-generation sequencing. Additionally, she is working with the Genome in a Bottle (GiaB) consortium to examine results from targeted sequencing panels on GiaB benchmark genomes. Targeted sequencing panels may offer a cost effective way of characterizing a high number of clinically important genomic regions.



Report of the 2019 NIST-FDA Workshop on Standards for Next Generation Sequencing Detection of Viral Adventitious Agents in Biologics and Biomanufacturing

Megan Cleveland, Bharathi Anekella, Mike Brewer, Pei-Ju Chin, Heather Couch, Eric Delwart, Jim Huggett, Scott Jackson, Javier Martin, Serge Monpoeho, Tom Morrison, Siemon Ng, David Ussery, Arifa Khan
Adventitious virus testing assures product safety by demonstrating the absence of viruses that may have been unintentionally introduced during the manufacturing

Development and Interlaboratory Evaluation of a NIST Reference Material RM 8366 for EGFR and MET Gene Copy Number Measurements

Hua-Jun He, Biswajit Das, Megan H. Cleveland, Chen Li, Corinne Camalier, Liang-Chu Liu, Kara L. Norman, Andrew Fellowes, Christopher McEvoy, Steven P. Lund, Jamie L. Almeida, Carolyn R. Steffen, Chris Karlovich, P. M. Williams, Kenneth D. Cole
The National Institute Standard and Technology (NIST) Reference Material RM 8366 was developed to improve the quality of gene copy measurements of EGFR
Created September 17, 2019, Updated June 15, 2021