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Bioanalytical Science Group

Providing the measurement science, standards, technology, and data required to support the nation's needs in determining the composition, structure, quantity, and function of proteins, glycans, oligonucleotides, and metabolites.

The Bioanalytical Science Group at NIST develops and validates reference methods, reference materials and reference data to enable accurate characterization of complex biological systems.  Our work underpins analytical measurements across diverse applications including mass spectrometry-based analysis of proteins, glycans and oligonucleotides. Recent efforts have focused on improving quantitative workflows for biomarker and food allergen quantification, along with establishing metrological traceability in assays for other biological materials.  Through collaborations with partners across U. S. industry, government agencies, academia and metrology institutes, we support measurement reproducibility and standardization critical to advancing biotechnology, biomanufacturing and laboratory medicine.

News and Updates

Kidney Disease Diagnosis and Monitoring

Kidney disease is a major global public health issue, with c hronic kidney disease (CKD) representing the 12 th highest cause of death worldwide. It has been

Awards

An Extraordinary Standard: New NIST Protein Could Spur Biopharmaceutical Innovation

NIST SRM 8671
Credit: Photograph taken by Matthew DeLorme

The National Institute of Standards and Technology (NIST) has issued one of the world’s most intricate measurement standards: an exhaustively analyzed antibody protein that the biopharmaceutical industry will use to help ensure the quality of treatments across a widening range of health conditions, including cancers, autoimmune disorders and infectious diseases.  Read More

Software

NIST Mass and Fragment Calculator Software

The NIST Mass and Fragment Calculator is a program written in Visual Basic which calculates the mass of an input peptide or protein sequence along with m/z ions

Isotope Enrichment Calculator

The NIST Isotope Enrichment Calculator is a program written in Visual Basic which determines the percentage of 15N enrichment of stable isotope-labeled peptides

Projects and Programs

Biomanufacturing Initiative

Ongoing
The objective of the NIST biomanufacturing program is to support US biopharmaceutical industry delivery of high quality and low cost protein drugs around the world. The mission is fulfilled through the development of standards, measurement science, and state of the art tools that support advances in

Development of Proteomics-Based Methods for Protein Quantification

Ongoing
Reference measurement procedures and standard reference materials help ensure that routine clinical assays provide accurate results across different laboratories and over time. Lists of such higher-order methods are published by the Joint Committee for Traceability in Laboratory Medicine (JCTLM)

Publications

Contacts

Group Leader

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