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Projects/Programs

Keyword

Organizational Unit

Developing Cost-Effective Relationships Between Federal Building Profiles and Seismic Retrofit Cost

Completed

Objective - To develop quantitative methods to evaluate the benefits and costs of risk mitigation activities implemented to improve seismic performance of buildings, based on building profiles (construction type, size, age, location), which can be applied to buildings that are federally owned...

Developing Cost-Effective Resource Allocation Strategies to Enhance Community Resilience

Ongoing

Objective To publish decision support tools and materials for engagement with end-user communities, professional organizations, and government agencies that provide comprehensive valuations of community resilience planning (monetary and non-monetary)—for both built and natural infrastructure –...

Developing a Detailed Analysis of the Transportation Equipment Manufacturing Industry Supply Chain

Ongoing

Objective - This project has three objectives: (1) to develop a detailed analysis of the US transportation equipment manufacturing industry supply chain that provides a temporal examination of the industry both domestically and internationally; (2) to revise and expand the E2013 Function Analysis...

Developing a Materials Innovation Infrastructure

Completed

Phase Field Community Hub ( PFHub) and Benchmarks The Phase Field Community Hub provides a framework that supports phase field practitioners and code developers participating in an effort to improve quality assurance for phase field codes. The main thrust of this effort is the generation of a set of...

Development of Biomarker-based Systems for Cancer Detection and Therapy

Completed

Intended impact Although significant progress has been made in both the understanding and treatment of cancer during the last thirty years, it remains the second leading cause of death in the US. The cancer community has set a goal to eliminate cancer-related suffering and death by 2015. To achieve...

Development of a Collagen Fibril Reference Material for Reproducible Cell Response

Ongoing

Research is ongoing to assess what information is required to validate films of collagen as reference extracellular matrix. During the first portion of this work we will develop protocols for characterizing the prototype collagen reference material with various instrumental techniques to develop...

Development of differential absorption LIDAR Technologies

Ongoing

The basic processes involved in elastic backscatter LIDAR are as follows. A laser emits a pulse of light (typically a few nanoseconds), and as the pulse propagates, the photons interact with molecules and aerosol particles. Some of these, the interactions with aerosols, such as Mie and Rayleigh...

Development of Enhanced mRNA Amplification Using Microfluidics

Completed

Intended Impact Tissue samples frequently contain multiple cell types. New methods (e.g. laser capture microdissection) enable the segregation of small quantities of individual cells and cell types, but the current methods to analyze global gene expression do not provide highly efficient profiling...

Development of a First-Generation Community-Resilience Systems Model

Ongoing

Objective Develop an efficient, interactive computer-based tool, Alternatives for Resilient Communities (ARC), to facilitate exploration of decision alternatives at the community scale for infrastructure systems (buildings, water, power, transportation) for a range of natural hazard events and...

Development of a First-Generation Community Resilience Assessment Methodology

Ongoing

Objective By 2028, develop and disseminate a database of county level community resilience indicators, an inventory and analysis of published frameworks and indicators, and scientifically grounded guidance necessary to quantitatively assess community resilience over time for the nation, based on...

Development and Implementation of the Community Resilience Planning Guides

Ongoing

Objective By 2028, publish updated community resilience planning and decision-making guidance documents that are supported by natural hazard and resilience planning & analysis tools, based on collaboration and engagement with end-user communities, professional organizations, and government agencies...

Development of Methods for Measurement of Vitamin D and its Metabolites in Foods, Fortified Foods, and Dietary Supplements

Ongoing

Vitamin D exists in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D3 is produced in the body after sun exposure and is also the form used in most fortified foods. Dietary supplements may contain either vitamin D2 or D3. Measurement of vitamin D in foods and dietary...

Development of the NIST Prototype Advanced Biometrology Laboratory

Ongoing

Currently, NIST is investing in a new type of metrology laboratory that is focused on the unique reference material and high quality assay protocols that are needed in the regenerative medicine and biotechnology communities. The laboratory design is centered on automation that can set up 1000’s of...

Figure contains text “Omics Data Quality” and human outline with arrows pointing from the human to the following specimen types: liver, serum, stool, plasma, urine. On either side of the human are analytical spectra and everything is surrounded by a decorative molecule structure circular border.

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

There is a significant need for tools to increase harmonization, comparability, and reproducibility between laboratories and/or studies, and to provide quality control of sample preparation and data analysis protocols utilized in untargeted omics analysis. Reference materials are being developed to...

Development of Reference Measurement Procedures and Reference Materials for Creatinine

Ongoing

Kidney function can be evaluated by determining the glomerular filtration rate (GFR), which provides an estimate of how well the kidneys are removing waste and excess fluid from the blood. The GFR is not measured directly. Instead, a measurement of serum creatinine is performed, and this value is...

Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum

Ongoing

Steroid hormones and thyroid hormones serve an essential function by regulating gene transcription. Improving the accuracy of clinical assays for hormones will improve diagnoses and result in earlier treatments. Therefore, reference methods for the measurement of steroid and thyroid hormones have...

Photograph of several clinical Standard Reference Materials showing labeled boxes, bottles, vials, ampoules and printed certificates.

Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers

Ongoing

Reference measurement procedures and standard reference materials help ensure accuracy and comparability of routine clinical assays. In addition, this work allows U.S. clinical diagnostic manufacturers to comply with the European Union directive regarding in-vitro diagnostic medical devices (IVD MD)...

NIST researcher pipetting solutions into 96-well plate for analysis

Development of Reference Methods and Reference Materials for Protein Biomarkers

Ongoing

Accuracy and reliability of clinical assays is essential for timely and accurate medical interventions. However, studies have shown that large variations in results can occur among routine clinical assays. In one example, a clinical comparison among 13 commercial cardiac troponin I assay platforms...

Development of Reference Methods and Reference Materials for the Determination of Cardiac Troponin I in Human Serum

Ongoing

The clinical measurement of serum cardiac troponin I (cTnI) has become one of the most important tools in the diagnosis of acute myocardial infarction and myocardial damage. Unfortunately, considerable variability in clinical cTnI assay results is observed when comparing assays from different...

Development of Serum-Based SRMs to Assess Nutritional Status

Ongoing

Vitamin deficiencies are generally considered rare in the U.S., but a growing body of evidence suggests that certain deficiencies may be more prevalent than originally thought. For example, it has been estimated that 10 % to 15 % of adults over the age of sixty are affected by vitamin B 12...

Photograph of SRM 2669 Arsenic Species in Frozen Human Urine, with vials and desiccant packs, and labeled mylar bag.

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure

Ongoing

Arsenic exposure in the U.S. population is an important part of the NHANES program conducted by CDC because dietary exposure to arsenic can cause serious health effects. A major challenge in the arsenic exposure assessment is that arsenic exists as various species in nature, and the toxicity of...

Development of SRM 955c Toxic Elements in Caprine Blood

Completed

Intended Impact Over the last three decades, NIST, with support from the Centers for Disease Control (CDC), and in conjunction with the New York State Department of Health’s (NYSDOH) Wadsworth Center, has produced a number of frozen whole blood certified reference materials containing endogenous...

Development of SRMs 2668 and 3668 for Accurate Assessment of Exposure to Toxic Elements and Anions

Completed

Toxic elements in the environment are a threat to public health and safety. Federal and state regulations have been issued to limit and abate the presence of toxic elements in the environment. The levels of toxic elements in the U.S. population are carefully monitored. NHANES is one of the federal...

an infographic showing four proposed standards connecting as four joined puzzle pieces

Development of Standards to Support a Modular and Autonomous Laboratory Ecosystem

Ongoing

Autonomous experimentation (AE), or self-driving laboratories, combines AI and automation while leveraging human intuition and creativity to guide experiment campaigns. AE can reduce the time and resources needed to discover new materials by orders of magnitude and reduce the time-to-market for...

Development of Standards for the World Meteorological Organization, Global Atmosphere Watch Program

Ongoing

Non-methane hydrocarbons (NMHCs) are emitted into the atmosphere by many biogenic and anthropogenic sources that include automobiles and other transportation vehicles, biomass burning, and oceans. In urban environments in particular NMHCs are important because they are precursors and contributors to...

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Advanced communications
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Information technology
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Infrastructure
Manufacturing
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-Product data
-Robotics
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-Supply chain
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Mathematics and statistics
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Metrology
-Amount of substance
-Dimensional metrology
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-Flow metrology and rheology
-Force metrology
-Humidity metrology
-Ionizing radiation metrology
-Mass metrology
-Metric
-Optical / photometry / laser metrology
-Pressure and vacuum metrology
-Thermometry metrology
-Time and frequency metrology
-Weights and measures
Nanotechnology
-Nanobiotechnology
-Nanochemistry
-Nanoelectronics
-Nanofabrication / manufacturing
--Lithography
--Self-assembly
-Nanofluidics
-Nanomagnetics
-Nanomaterials
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Neutron research
Performance excellence
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Physics
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-Biological physics
-Condensed matter
-Electron physics
-Magnetics
-Nuclear physics
-Optical physics and communications
-Quantum information science
-Radiation
-Spectroscopy
-Thermodynamics
-Time and frequency
Public safety
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-First responder preparedness
-Law enforcement
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-Response robots
Resilience
-Community resilience
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--Resilience metrics
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Standards
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Technology transfer
Transportation
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