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Projects/Programs

Keyword

Organizational Unit

Designing the Nanoworld: Nanostructure, Nanodevices, and Nano-optics

Ongoing

Developing and exploiting nanodevices for quantum and nanotechnologies requires nanoscale and atomic scale modeling of ultrasmall structures, devices, their operation, and their response to probes. Key challenges of understanding physics at the quantum/classical interface and measurement at the

Detecting Change Points in Surface Temperature Records

Ongoing

DESCRIPTION: For the purpose of exposition, consider the record daily minimums averaged by month for a station near Reno Nevada. There is a clear drop in the level between 1920 and 1940 and a positive drift starting at about 1980. There is also however, considerable variability due to seasonal

Detector metrology

Ongoing

Improved detector technology in the past two decades has opened a new era in detector metrology of optical radiation measurements. Lower calibration and measurement uncertainties can be achieved with modern detector/radiometer standards than traditionally used source standards (blackbodies and lamps

Detector Readout Project

Ongoing

NIST’s Quantum Sensors Division develops highly sensitive cryogenic sensors, for example transition-edge sensors (TESs) and kinetic inductance detectors (KIDs), to enable precision measurements in a large range of scientific applications. The successful implementation of these novel sensor

Detector-based color scale

Ongoing

The expanded uncertainty of the NIST primary color-temperature lamp-standards is 8 K ( k=2). However, both the long-term stability and the spectral distribution of the lamps can significantly change with burning time. By performing the tristimulus colorimeter calibrations against detector standards

Determinations of Boron Deposit Quality by Neutron Depth Profiling

Ongoing

Neutrons are not easily detected with high resolution and good efficiency. Consequently, high-quality neutron detectors remain a challenge to manufacture. A few nuclides such as He-3, Boron-10, and Li-6 are commonly used to convert impinging neutrons into an electrical pulse that post-processing

Developing Cost-Effective Relationships Between Federal Building Profiles and Seismic Retrofit Cost

Completed

Objective - To develop quantitative methods to evaluate the benefits and costs of risk mitigation activities implemented to improve seismic performance of buildings, based on building profiles (construction type, size, age, location), which can be applied to buildings that are federally owned

Developing Cost-Effective Resource Allocation Strategies to Enhance Community Resilience

Ongoing

Objective - To support community resilience planning through the development of tools that evaluate the economic impacts of disruptive events, including accounting for uncertainties of future events and measuring the co-benefits from resilience planning actions. What is the new technical idea

Developing a Detailed Analysis of the Transportation Equipment Manufacturing Industry Supply Chain

Ongoing

Objective - This project has three objectives: (1) to develop a detailed analysis of the US transportation equipment manufacturing industry supply chain that provides a temporal examination of the industry both domestically and internationally; (2) to revise and expand the E2013 Function Analysis

Developing a Materials Innovation Infrastructure

Ongoing

Phase Field Community Hub ( PFHub) and Benchmarks The Phase Field Community Hub provides a framework that supports phase field practitioners and code developers participating in an effort to improve quality assurance for phase field codes. The main thrust of this effort is the generation of a set of

Development of Biomarker-based Systems for Cancer Detection and Therapy

Ongoing

Intended impact Although significant progress has been made in both the understanding and treatment of cancer during the last thirty years, it remains the second leading cause of death in the US. The cancer community has set a goal to eliminate cancer-related suffering and death by 2015. To achieve

Development of a Collagen Fibril Reference Material for Reproducible Cell Response

Ongoing

Research is ongoing to assess what information is required to validate films of collagen as reference extracellular matrix. During the first portion of this work we will develop protocols for characterizing the prototype collagen reference material with various instrumental techniques to develop

Development of Enhanced mRNA Amplification Using Microfluidics

Ongoing

Intended Impact:Tissue samples frequently contain multiple cell types. New methods (e.g. laser capture microdissection) enable the segregation of small quantities of individual cells and cell types, but the current methods to analyze global gene expression do not provide highly efficient profiling

Development of a First-Generation Community Resilience Assessment Methodology

Ongoing

Objective - To develop the tools necessary for communities to quantitatively assess their resilience over time based on a suite of community resilience indicators that account for meaningful aspects of the physical, social, and economic systems. What is the new technical idea? Currently, communities

Development of a First-Generation Community-Resilience Systems Model

Ongoing

Objective - To develop computer-based tools that facilitate exploration of decision alternatives for community resilience and that specifically address key challenges related to the scale and interdependencies of the system and the complexities of the planning process. What is the new technical idea

Development and Implementation of the Community Resilience Planning Guides

Ongoing

Objective - To develop guidance documents ( Community Resilience Planning Guide for Buildings and Infrastructure Systems and supporting Guide Briefs) to improve community resilience and to collect data from communities implementing the guidance documents to inform future versions. What is the new

Development of Methods for Measurement of Vitamin D and its Metabolites in Foods, Fortified Foods, and Dietary Supplements

Ongoing

Vitamin D exists in two forms: vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). Vitamin D3 is produced in the body after sun exposure and is also the form used in most fortified foods. Dietary supplements may contain either vitamin D2 or D3. Measurement of vitamin D in foods and dietary

Development of the NIST Prototype Advanced Biometrology Laboratory

Ongoing

Currently, NIST is investing in a new type of metrology laboratory that is focused on the unique reference material and high quality assay protocols that are needed in the regenerative medicine and biotechnology communities. The laboratory design is centered on automation that can set up 1000’s of

Figure contains text “Omics Data Quality” and human outline with arrows pointing from the human to the following specimen types: liver, serum, stool, plasma, urine. On either side of the human are analytical spectra and everything is surrounded by a decorative molecule structure circular border.

Development of NIST Reference Materials for Untargeted Metabolomics, Lipidomics and Proteomics

Ongoing

There is a significant need for tools to increase harmonization, comparability, and reproducibility between laboratories and/or studies, and to provide quality control of sample preparation and data analysis protocols utilized in untargeted omics analysis. Reference materials are being developed to

Development of Proteomics-Based Methods for Protein Quantification

Ongoing

Reference measurement procedures and standard reference materials help ensure that routine clinical assays provide accurate results across different laboratories and over time. Lists of such higher-order methods are published by the Joint Committee for Traceability in Laboratory Medicine (JCTLM)

Development of Rapid Multiplex PCR Techniques

Ongoing

With the continuing development of miniaturization technologies such as microfluidic and micro-capillary devices there is a desire to reduce the overall time required to type DNA samples. Such miniature devices could be used for initial screening at a crime scene, at a border, or at airports. There

Human Vitamin D Binding Protein in complex with 25-hydroxyvitamin D3

Development of Reference Materials and Methods for Vitamin D Binding Protein

Ongoing

Vitamin D is essential for bone health, and vitamin D deficiency can lead to rickets in children and osteomalacia (soft bones) in adults. Vitamin D status is typically monitored through measurement of the metabolite 25-hydroxyvitamin D [25(OH)D] in serum. Most 25(OH)D is tightly bound to its

Development of Reference Measurement Procedures and Reference Materials for Creatinine

Ongoing

Kidney function can be evaluated by determining the glomerular filtration rate (GFR), which provides an estimate of how well the kidneys are removing waste and excess fluid from the blood. The GFR is not measured directly. Instead, a measurement of serum creatinine is performed, and this value is

Photograph of several clinical Standard Reference Materials showing labeled boxes, bottles, vials, ampoules and printed certificates.

Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers

Ongoing

Reference measurement procedures and standard reference materials help ensure accuracy and comparability of routine clinical assays. In addition, this work allows U.S. clinical diagnostic manufacturers to comply with the European Union directive regarding in-vitro diagnostic medical devices (IVD MD)

Development of Reference Methods and Reference Materials for the Determination of Hormones in Human Serum

Ongoing

Steroid hormones and thyroid hormones serve an essential function by regulating gene transcription. Improving the accuracy of clinical assays for hormones will improve diagnoses and result in earlier treatments. Therefore, reference methods for the measurement of steroid and thyroid hormones have

NIST Headquarters
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---Building Energy and Environment Division
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---Materials and Structural Systems Division
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----Polymeric Materials Group
----Structures Group
---Engineering Laboratory Office
----Applied Economics Office
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---Fire Research Division
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---Materials Science and Engineering Division
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Advanced communications
-Open Radio Access Network (Open-RAN)
-Quantum communications
-Spectrum sharing
-Wireless (RF)
Bioscience
-Bioimaging
-Bioinformatics
-Biomanufacturing
-Biomaterials
-Cell biology
-Cell-free systems
-Engineering / synthetic biology
-Gene delivery systems
-Genome editing
-Genomics
-Glycomics
-Metabolomics
-Microbial measurements
-Proteomics
-Sequence screening
-Transcriptomics
Buildings and Construction
-Building codes and standards
-Building control systems
-Building damage and repair
-Building economics
-Building materials
-Energy efficiency
-Heating, ventilation and air conditioning equipment
-Indoor air quality
-Structural engineering
-Thermal comfort
Chemistry
-Analytical chemistry
-Chemical engineering and processing
-Chemical thermodynamics and chemical properties
-Molecular characterization
-Theoretical chemistry and modeling
-Thermochemical properties
Electronics
-Electromagnetics
-Flexible electronics
-Magnetoelectronics
-Optoelectronics
-Organic electronics
-Semiconductors
-Sensors
-Superconducting electronics
Energy
-Alternative energy
-Conventional energy
-Electric power / smart grid
-Fuels
Environment
-Air / water / soil quality
-Climate
-Environmental health
-Greenhouse gas measurements
-Marine science
-Sustainability
Fire
-Emergency building evacuation
-Fire detection
-Fire dynamics and science
-Fire fighting
-Fire modeling
-Fire risk reduction
-Materials flammability
-Structural fire resistance
-Wildland urban interface fire
Forensic Science
-Digital evidence
-Drugs and toxicology
-Firearms and toolmarks
-Forensic biometrics
-Forensic genetics
-Trace evidence
Health
-Biopharmaceuticals
-Cell and gene therapy
-Clinical diagnostics
-Dentistry
-Food and nutrition
-Human microbiome
-Medical imaging
-Precision medicine
-Regenerative medicine and advanced therapy
Information technology
-Artificial intelligence
--AI measurement and evaluation
--Applied AI
--Fundamental AI
--Hardware for AI
--Machine learning
--Trustworthy and responsible AI
-Biometrics
-Cloud computing and virtualization
-Complex systems
-Computational science
-Conformance testing
-Cyber-physical systems
--Smart cities
-Cybersecurity
--Cryptography
--Cybersecurity education and workforce development
--Cybersecurity measurement
--Identity and access management
--Privacy engineering
--Risk management
--Securing emerging technologies
--Trustworthy networks
--Trustworthy platforms
-Data and informatics
--Human language technology
--Information retrieval
--Natural language processing
-Federal information processing standards (FIPS)
-Health IT
-Internet of Things (IoT)
-Interoperability testing
-Location based services
-Mobile
-Networking
--Mobile and wireless networking
--Network management and monitoring
--Network modeling and analysis
--Network security and robustness
--Network test and measurement
--Next generation networks
--Protocol design and standardization
--Software defined and virtual networks
-Privacy
-Software research
--Software testing
-Usability and human factors
--Accessibility
-Video analytics
-Virtual / augmented reality
-Visualization research
-Voting systems
Infrastructure
Manufacturing
-Additive manufacturing
-Factory communications
-Factory operations planning and control
-Interoperability in manufacturing
-Machining
-Manufacturing economics
-Manufacturing quality assurance
-Manufacturing systems design and analysis
-Monitoring, diagnostics and prognostics
-Process improvement
-Process measurement and control
-Product data
-Robotics in manufacturing
--Agility and adaptability
--Collaborative robots
--Dexterous grasping
--Manipulation
--Mobility and industrial autonomous vehicles
--Navigation / actuation / control
--Sensing and perception
-Supply chain
-Sustainable manufacturing
-Systems engineering
-Systems integration
-Technology commercialization
Materials
-Ceramics
-Composites
-Concrete / cement
-Materials characterization
--Composition and structure
--Mechanical properties
--Thermal properties
-Metals
-Modeling and computational material science
-Polymers
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Mathematics and statistics
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