Projects/Programs

Displaying 1 - 10 of 10

Assay Development for Cell-Free Expression Systems

Ongoing

Current practices for characterizing cell-free expression systems are limited and unsuitable to advance these technologies beyond the state-of-the-art. To meet this measurement need, the Cellular Engineering Group is developing quantitative assays to benchmark cell extracts, reagents, and cell-free...

Biosecurity for Synthetic Nucleic Acid Sequences

Ongoing

Synthetic nucleic acid technologies are fundamental to U.S. biotechnology and biomanufacturing innovation. However, like other transformative technologies, they carry dual-use potential: while they can drive significant progress, they pose risks of unintentional or deliberate misuse to engineer...

Map of the world with the engineering biology topics covered in Americas, Europe, and Asia meetings

Engineering Biology Metrics and Technical Standards for the Global Bioeconomy

Ongoing

Stakeholders from the Americas, Asia and Australia, and Europe and Africa, came together through a series of regional workshops in Washington D.C., Singapore, and Brussels, respectively, to identify specific areas for development, both technical and non-technical towards continued scale-up and economic growth across the bioeconomy.

Gears illustrating NIST's cell-free systems initiatives

Metrology For Cell-Free Expression Systems

Ongoing

Cell-free expression systems are poised to advance the US bioeconomy and play a key role in ensuring US manufacturing resilience. NIST has several, on-going projects in its growing portfolio to promote reproducibility, new measurement methods, and best practices and standards in cell-free expression...

NIST Living Measurement Systems Foundry

Ongoing

To enable the production of high-throughput, high-quality data that meets the rapidly evolving needs of current and future stakeholders, NIST has established an automation facility for the growth, manipulation, sample preparation, and measurement of engineered microbes. The core of the facility...

Test tube illustrating NIST cell-free workshop topics

NIST Workshops on Cell-Free Expression Systems

Completed

NIST has co-hosted two cell-free workshops. NIST CELL-FREE (Comparable Engineered Living Lysates For Research Education and Entrepreneurship) Workshop (2019) The NIST CELL-FREE workshop took place in La Jolla, CA in February 2019, in collaboration with the J. Craig Venter Institute (JCVI). The...

Protocols, datasets, and software for engineering biology

Ongoing

Published protocols, datasets, and software for engineering biology from the Cellular Engineering Group. Protocols Romantseva E., Ross D., Alperovich N., Strychalski E., Automated DNA template preparation and quantitation methods, https://www.protocols.io, March 23, 2022, https://dx.doi.org/10.17504...

RNA Computation and Metrology for Engineering Biology

Ongoing

RNA computation RNA computation, i.e., programmed interactions between RNA molecules that process information, is an increasingly useful synthetic biology tool with applications spanning in vitro biosensing, synthetic cells, and cellular control. We have developed cotranscriptionally encoded RNA...

Synthetic Biology

Ongoing

New measurement methods and tools are required for biology to emerge fully as an enabling, practical platform for engineering. The Cellular Engineering Group works to provide a foundation of measurement assurance to support the control and rational design of biological function. Through state of the...

Synthetic Biology Standards Consortium (SBSC)

Completed

The SBSC is an open and voluntary consortium consisting of private companies, academic researchers, and public entities convened and hosted by NIST. The objective of the SBSC is to collectively build the metrology infrastructure to support a fully integrated, global synthetic biology enterprise. A...

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