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Standards

Reference materials

Projects/Programs

Displaying 76 - 100 of 132

Mouse Allelic Ladder

Ongoing
What is an allelic ladder? An allelic ladder is a mixture of highly characterized alleles (known size and sequence) that are generated using the same primers as the test samples and are used during capillary electrophoresis for accurate allele call determination. Why is an allelic ladder important
USAXS animation

Multiscale structure and dynamics in advanced technological materials

Ongoing
New technologies increasingly harness materials phenomena that operate across many length-scales: e.g., in selective gas adsorption, additive manufacturing, new alloy designs, or advanced concretes. To overcome technology barriers, it is no longer sufficient just to characterize the materials
Carbon Nanotubes imaged via Focused Ion Beam Scanning Electron Microscope.

Nanotube Quality Control

Completed
Thermogravimetric analysis (TGA) is widely used to gather data on nanotube chemistry. By monitoring weight loss as a function of temperature, one can determine decomposition kinetics and use this data to closely approximate the distribution of impurities present in a few milligrams of material
Photograph of an automobile at an emissions testing station, with testing equipment and probe positioned at the car tailpipe.

New Gas Standard Reference Materials to Support the Automotive Industry

Completed
NIST currently supports AIGER members by maintaining reasonable inventories of required gas SRMs that consist of dilute mixtures of key pollutants such as carbon dioxide, carbon monoxide, hydrocarbons, and nitric oxide. Newer vehicles produce lower levels of these pollutants because their engines
Conceptual Art of Gas Molecules Adsorbed in a Zeolite Adsorbent

NIST Data Resources for Adsorption

Ongoing
NIST/ARPA-e Database of Novel and Emerging Adsorbent Materials A centralized resource for the scientific community to find and compare single- and multi-component adsorption isotherms reported in the literature. The database sorts data according to adsorbent material, adsorbate species
Flow Cytometry Consortium

NIST Flow Cytometry Standards Consortium 

Ongoing
Advances in cell and gene-based therapeutics as well as other regenerative medicine products have increased the need for high quality, robust, and validated measurements for cell characterization. Flow cytometry, including imaging cytometry, has emerged as an important platform due to its ability to
photo collage of meats, cheese, eggs, fish, and shellfish

NIST Food Safety Program

Ongoing
The Food Safety Program at the National Institute of Standards and Technology (NIST) provides advanced analytical chemistry and quantitative biology to ensure that food is free of contaminants and allergens and is authentic, promoting U.S. manufacturers’ participation in domestic and foreign markets
HER2 SRM Unit and Individual Components

NIST HER2 Genomic DNA Standard Reference Material, SRM® 2373

Ongoing
The amplification of the gene for HER2 occurs in approximately 20 to 25% of breast cancers. The accurate measurement of this biomarker is important for the proper treatment with anti-HER2 therapeutics. Clinical laboratories are beginning to utilize accurate and sensitive diagnostic tests based on
NISTmAb RM8671 vial and 3D printed model

NIST Monoclonal Antibody Reference Material 8671

Ongoing
The NISTmAb material is a recombinant humanized IgG1κ expressed in murine suspension culture. It is an »150 kDa homodimer of two identical light chains and two identical heavy chains linked through both inter- and intra-chain disulfide bonds. The protein has low abundance post-translational
AdobeStock_496492664

NIST Ocean Carbon Measurements

Ongoing
NIST is committed to sustaining the quality of ocean carbon measurements by developing capabilities to provide certified reference materials for the ocean carbonate system measurements and by conducting research to understand fundamental elements of the ocean carbon thermodynamic system. NIST Ocean
NIST PS1

NIST PS1 Primary Standard for quantitative NMR (Benzoic Acid)

Completed
With explicit SI linkage, the overall impact of this apical reference material is profound—this primary standard, as well as forthcoming members of its class, provides technology transfer of chemical purity realization to the commercial sector for characterization of many thousands of organic
Photograph of the NIST Standard Reference Photometer showing the component modules consisting of optical bench with sample and reference tubes, ozone generator module with controls and tubing, and control module with numeric LED displays.

The NIST Standard Reference Photometer for Ozone Measurement Traceability

Ongoing
The concentration of ozone in the atmosphere continues to be an important global issue both scientifically and politically. Stratospheric ozone protects the Earth from harmful UV radiation, while tropospheric ozoneis a major health concern and contributes to global climate change as a greenhouse gas
Cannabis

NIST Tools for Cannabis Laboratory Quality Assurance

Ongoing
Since the 1970s, cannabis (marijuana and hemp) and its constituent, Δ 9-tetrahydrocannabinol or THC, have been classified as Schedule I controlled substances. Seized evidence is tested by forensic laboratories, which verify the identity of the plant through macro- and microscopic evaluation and the
Photograph of hundreds of gas cylinders in a gas storage facility.

NIST Traceable Reference Material Program for Gas Standards

Ongoing
The Gas Mixture SRM, NTRM, and EPA Protocol Programs provide a mechanism to produce needed calibration gas standards with a well-defined traceability. These mixtures are specified in the Code of Federal Regulations (CFR) to calibrate instruments to be used to monitor regulated emissions. The NTRM
Reference Measurement System for Urine Albumin

NIST Urine Albumin Standardization Program

Ongoing
Kidney disease is a major global economic and public health issue, with chronic kidney disease (CKD) representing one of the top 10 most prominent causes of death worldwide. The public health and economic impact of CKD and other kidney diseases has led to the need for the accurate detection of
Box for NISTCHO in center, vial of NISTCHO to the right

NISTCHO

Ongoing
NISTCHO, a new mammalian cell line of interest to the biopharmaceutical and biomanufacturing communities, is now available from the National Institute of Standards and Technology. This Chinese hamster ovary (CHO) cell line has been engineered by MilliporeSigma to express a non-originator version of
]: Photograph of two vials containing human milk Standard Reference Materials.

Organic Compounds in Human Serum, Milk, and Urine

Ongoing
Standard Reference Materials (SRMs) have been specifically designed to assist in the quality assurance measurements for compounds found in human fluids. Clinical and biomonitoring laboratories rely on these SRMs for method validation and as control materials during specific analyses. Various human

Pathogen Detection and Identification: The Next Generation of Analyses

Ongoing
Human disease resulting from pathogens represents a tremendous burden on the health care system. Many hospitals have adopted new, rapid polymerase chain reaction (PCR)-based detection systems because the time to diagnose and begin effective treatment has a direct impact on patient survival and
Picture of PBD set up for wavelength measurement

Powder Diffraction SRMs

Ongoing
This program strives to produce the highest-quality, traceable powders and other artifacts for x-ray diffraction calibration. (to be completed)

Precursor Material Qualification

Completed
To develop, utilize, and analyze methods of characterizing the precursor materials in additive manufacturing in both virgin and recycled states with the goal of advancing measurement science to benefit the AM community. The components of principal interest will include the rheological, size

Protein rheology measurements

Ongoing
Intended Impact Why does the health-care industry care about rheology and scattering of protein solutions? Operations. Viscosity is a critical and fundamental constitutive input for drug delivery, device design and manufacturing. For example, high viscosity leads to poor syringeability due to high

Radioanalytical Metrology

Ongoing
The Group engages in a wide range of methods applicable to the detection and characterization of nuclear materials. The work can benefit environmental studies, waste remediation, naturally occurring radioactivity detection and characterization and general radioanalytical metrology. Expertise in
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