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Chemistry

Analytical chemistry

Projects/Programs

Keyword

Organizational Unit

Traceability in Molecular Spectrophotometry

Ongoing

This program, sometimes referred to as the Optical Filters program, has supported the development, certification, and (as specified) recertification of Standard Reference Materials ® (SRMs ®) for the verification of the transmittance (absorbance) and wavelength scales of spectrophotometers in the...

Photography of gas cylinder storage facility with cylinders stored horizontally in movable cabinets.

Traceable Calibration Gases: SRMs, NTRMs, and Protocol Gases

Ongoing

The Gas Sensing Metrology Group prepares the highest level gas standards, known as Primary Standard Gas Mixtures based on precise gravimetric methods and accurate purity analysis. These Primary Standards are verified at NIST, stability confirmed through reanalysis over many years, and compared...

Online video tutorials education button in Laptop notebook computer screen. Play lesson concept. Vector illustration

Tutorials in Analytical Chemistry

Ongoing

Topic Links Laboratory Operations and Sample Processing Use of Analytical Balances Video N/A Volumetric Transfer of Liquids Video PowerPoint Determination of Liquid Density Video PowerPoint Preparation of Calibration Solutions Video PowerPoint Soxhlet Extractions Video PowerPoint Pressurized Fluid...

Series of MRI images labeled A to E showing different views of brain tissue, some with gadolinium highlighted in blue against a purple background.

Understanding the Bioaccumulation of Gadolinium-Based Contrast Agents using Advanced Measurement Capabilities

Ongoing

Researchers and staff from the Medical University of South Carolina are collaborating with NIST staff experienced in trace elemental speciation, sample preparation and instrumental analysis in order to demonstrate the bioaccumulation of intact GBCA in patients who have repeated GBCA exposure...

Unfolding and Aggregation of Therapeutic Proteins

Completed

A stable protein formulation is essential to the safety of mAb drugs. In particular, mAb drug solutions formulated at high concentrations can undergo various biophysical instabilities, such as aggregation and liquid-liquid phase separation. These undesired solution properties are primarily driven by...

Vapor Sampling in the Field

Ongoing

Breath sampling of cannabis users. Several versions of breath collection devices are being marketed for the detection of THC (delta-9-tetrahydrocannabinol) in the breath of cannabis users. THC is not directly correlated to intoxication but may indicate recent smoking or vaping. THC and other...

Vapor Sampling to Support Public Safety and Forensics

Ongoing

Vapor pressures of unstable, reactive compounds. Over the last decade, our group has investigated a variety of low-volatility compounds including taggants (found in explosives), biofuels, terpenes and cannabinoids. Dynamic vapor microextraction (DVME), developed at NIST, is a small-volume dynamic...

Vitamin D Metabolites Quality Assurance Program (VitDQAP)

Completed

Interlaboratory comparison studies of the VitDQAP supported the reliability of vitamin D measurements, including determination of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, and 3- epi-25-hydroxyvitamin D3 in human serum and plasma. Results from the comparison studies helped participants to make...

Wildland-Urban Interface (WUI) Smoke Production and Exposure Mitigation

Ongoing

This project develops measurement science and technology to 1) accurately estimate WUI smoke production and its chemical makeup, and 2) assess hazards and effective mitigation actions to reduce smoke exposure to first responders, building occupants, and WUI fire evacuees.

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