Researchers and staff from the Medical University of South Carolina are collaborating with NIST staff experienced in trace elemental speciation, sample preparation and instrumental analysis in order to demonstrate the bioaccumulation of intact GBCA in patients who have repeated GBCA exposure. Patients with as few as four GBCA exposures are shown to have detectable levels of gadolinium. The use of laser ablation coupled to inductively-coupled mass spectrometry permits detection of this bio-accumulation in specific regions of the brain. Additional research to determine the mechanism for the gadolinium accumulation is ongoing.
- Justin P. Bandino, Harriet B. Hinen, Robert M. Gathings, Marta T. Hampton, W. Clay Davis, Dirk M. Elston, “Gadolinium Presence Within Cutaneous Sclerotic Bodies Confirmed by Laser Ablation Inductively Coupled Plasma Mass Spectrometry,” JAMA Dermatology, 154 (1) 105-106, 2018.