U.S. flag

An official website of the United States government

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

Material Measurement Laboratory

Projects/Programs

Displaying 126 - 150 of 568

Development of Reference Methods and Reference Materials for Proteins

Ongoing
Accuracy and comparability of clinical assays is essential for timely and accurate medical interventions. However, studies have shown that large variations in results can occur among routine clinical assays. A clinical comparison among 14 commercial assay platforms revealed more than 20-fold
Photograph of SRM 3950 Vitamin B6 in Frozen Human Serum with labeled box and frosty capped bottles containing level 1 and level 2.

Development of Serum-Based SRMs to Assess Nutritional Status

Ongoing
Vitamin deficiencies are generally considered rare in the U.S., but a growing body of evidence suggests that certain deficiencies may be more prevalent than originally thought. For example, it has been estimated that 10 % to 15 % of adults over the age of sixty are affected by vitamin B 12
Photograph of SRM 2669 Arsenic Species in Frozen Human Urine, with vials and desiccant packs, and labeled mylar bag.

Development of SRM 2669 for Accurate Assessment of Arsenic Exposure

Ongoing
Arsenic exposure in the U.S. population is an important part of the NHANES program conducted by CDC because dietary exposure to arsenic can cause serious health effects. A major challenge in the arsenic exposure assessment is that arsenic exists as various species in nature, and the toxicity of
GC-ICP-MS Chromatogram

Development of SRM 955c Toxic Elements in Caprine Blood

Completed
Intended Impact Over the last three decades, NIST, with support from the Centers for Disease Control (CDC), and in conjunction with the New York State Department of Health’s (NYSDOH) Wadsworth Center, has produced a number of frozen whole blood certified reference materials containing endogenous
Lattice constant for AI using various exchange-correlation functionals

DFT Benchmarking

Ongoing
Since its inception exactly 50 years ago this year, density-functional theory (DFT) has evolved from an exotic idea of physicists into the most-widely used tool for the computational prediction of materials’ structures and electronic, optical, magnetic, and mechanical properties. While DFT presents

DFT Repositories and Informatics

Ongoing
Historically, the printed article has served as the medium de rigueur for the dissemination of scientific information. This works well when the context and results of an experiment or theory fit on a few pages; however, it is insufficient as a publication medium for many computational studies. For
Dietary QAP

Dietary Supplement Laboratory Quality Assurance Program (DSQAP)

Ongoing
Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing an annual expenditure of more than $20 billion. Regulations, driven by reported cases of inaccurate labeling, adulteration, contamination (with pesticides, heavy metals, or
Dietary QAP

Dietary Supplement Laboratory Quality Assurance Program (DSQAP) Consortium

Ongoing
The objective of the DSQAP Consortium is to develop and evaluate measurement methods and standards to support quality and safety for the dietary supplement testing community. Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing
Picture of PBD set up for wavelength measurement

Diffraction Metrology and Standards

Ongoing
Diffraction techniques can provide data on a number of sample characteristics. Therefore, the method of certification and the artifact itself are chosen to address a specific measurement issue pertinent to a diffraction experiment. NIST diffraction SRMs may be divided into five groups: Line Position
Instrumentation that create and read droplets for digital PCR measurements.

Digital PCR

Ongoing
With appropriately validated assays, digital polymerase chain reaction (dPCR) determines the number of DNA targets (copies) per reaction partition, without the need for a standard curve. Reaction partitions can be in the form of fixed chambers in a microfluidic device, referred to as chamber digital

Dimensional Metrology for Nanoscale Patterns

Completed
Dimensional metrology and control is a critical component of semiconductor fabrication. State-of-the-art integrated circuits are comprised of nearly a billion nanoscale transistors linked together by an equally as impressive nanoscale network of conductors, insulators, and capacitors. To ensure that

Directed Self Assembly of Block Copolymers for Nanopatterning

Ongoing
One of the key issues for DSA is the three dimensional structure of the block copolymer. For the example of line-space patterns made using lamella-forming block copolymers, it is possible to have the DSA form tilted lamella or complex mixed morphologies that are a combination of vertical and
A plot of data representing the peaks from a three person DNA profile

DNA Mixture Interpretation

Ongoing
Interlaboratory Studies Mixture interlaboratory studies provide a means to assess a laboratory's ability to process and interpret DNA mixtures. Initial ‘Mixed Stain’ studies (published in 2001) provided physical samples for DNA profiling with the first commercial STR typing tests. Later, mixture

Drug Analysis - Opioids and Emerging Threats

Ongoing
Package Interdiction Many synthetic opioids and novel psychoactive substances enter the country through international mail. Research in this area focuses on measurement challenges associated with detection and analysis of these packages at the point of seizure in international mail facilities

Dynamic Plasticity: Non-Equilibrium Mechanics

Ongoing
The optimization of high-speed machining processes through powerful finite element modeling techniques is an important pathway to American manufacturing competitiveness in an increasingly competitive global marketplace. Quantitatively accurate simulations of machining rely on robust constitutive

Ecogenotoxicity Measurements of Nanoparticles

Completed
Intended Impact Understanding the potential environmental fate of NPs has direct implications to the US economy, as potential environmental and human health impacts of NPs is one of the main factors slowing the commercialization of this technology. Reducing the uncertainty regarding the

Electrochemistry

Ongoing
Operando Measurements Measurements of the structure and dynamics of metal-electrolyte interfaces are essential for understanding mechanisms of electrocatalysis and electrodeposition that are key to optimization of materials processing and utilization in wet chemical environments. Our measurement
Was this page helpful?