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Search Publications by Charles Camp

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Displaying 1 - 10 of 10

pyMCR: A Python Library for Multivariate Curve Resolution Analysis

June 24, 2019
Charles H. Camp
In this work, a new software library is presented for performing multivariate curve resolution (MCR)analysis, a chemometric method for elucidating signatures of analytes ("endmember extraction") and their relative abundance (regression) from a series of

Broadband Coherent Anti-Stokes Raman Scattering

August 11, 2016
Charles H. Camp
Broadband coherent anti-Stokes Raman scattering (BCARS) microspectroscopy is a unique label-free imaging modality that provides detailed chemical information at each pixel. In minutes, this technique captures a “hyperspectral” cube that co-registers

Beam-Scanning for Rapid Coherent Raman Hyperspectral Imaging

December 14, 2015
Seungwan Ryu, Charles H. Camp, Ying Jin, Marcus T. Cicerone, Young J. Lee
Coherent Raman imaging requires high peak power laser pulses to maximize the nonlinear multiphoton signal generation, but accompanying photo-induced sample damage often poses a challenge to microscopic imaging studies. We demonstrate that a beam-scanning

Chemically-Sensitive Bioimaging with Coherent Raman Scattering

April 29, 2015
Charles H. Camp, Marcus T. Cicerone
Raman scattering provides an intrinsic fingerprint of chemical composition. Spontaneous Raman spectroscopy has been used for many decades to interrogate biological materials and systems, but is not widely used for imaging due to relatively slow signal

High-Speed Coherent Raman Fingerprint Imaging of Biological Tissues

July 20, 2014
Charles H. Camp, Young J. Lee, John M. Heddleston, Christopher M. Hartshorn, Angela R. Hight Walker, Jeremy N. Rich, Justin D. Lathia, Marcus T. Cicerone
We have developed a coherent Raman imaging platform using broadband coherent anti-Stokes Raman scattering (BCARS) that provides an unprecedented combination of speed, sensitivity, and spectral breadth. The system utilizes a unique configuration of laser

Measuring Stem Cell Dimensionality in Tissue Scaffolds

April 1, 2014
Carl G. Simon Jr., Sapun Parekh, Christopher K. Tison, Girish Kumar, Tanya M. Farooque, Charles H. Camp
Many 3D scaffold systems have evolved for tissue engineering, drug screening and in vitro tissue models. However, it is not clear which scaffolds provide a 3D cell niche and there is no clear way to measure cell niche dimensionality. Advances in 3D niche

Multicomponent Chemical Imaging of Pharmaceutical Solid Dosage Forms with Broadband CARS Microscopy

July 15, 2013
Christopher M. Hartshorn, Marcus T. Cicerone, Young J. Lee, Charles H. Camp, John M. Heddleston, Patrick Marsac, Tim Rhodes, Zhen Liu, Nicole Canfield
We compare broadband coherent anti-Stokes Raman scattering (BCARS) microscopy with spontaneous Raman microscopy for quantitative and qualitative assessment of multicomponent pharmaceuticals. Indomethacin was used as a model active pharmaceutical ingredient