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Search Publications by

Elijah Petersen (Fed)

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Displaying 1 - 25 of 95

Potential artifacts and control experiments in toxicity tests of nanoplastic and microplastic particles

October 14, 2022
Elijah Petersen, Ana Barrios, Theodore Henry, Monique Johnson, Albert Koelmans, Antonio Montoro Bustos, Joanna Matheson, Matthias Roesslein, Jian Zhao, Baoshan Xing
To fully understand the potential ecological and human health risks from nanoplastics and microplastics (NMPs) in the environment, it is critical to make accurate measurements. Similar to past research on the toxicology of engineered nanomaterials, a broad

Technical Framework for High Quality New Approach Methodologies (NAMs)

July 15, 2022
Elijah Petersen, John T. Elliott, John Gordon, Nicole Kleinstreuer, Emily Reinke, Matthias Roesslein, Blaza Toman
New approach methodologies (NAMs) are in vitro, in chemico, and computational approaches that can potentially be used to reduce animal testing. For NAMs that require laboratory experiments, it is critical that they provide consistent and reliable results

Current Ecotoxicity Testing Needs Among Selected U.S. Federal Agencies

June 2, 2022
Patricia Ceger, David Allen, Elyssa Arnold, Jennifer Brennan, Lyle Burgoon, Raanan Bloom, Carol Clarke, Natalia Garcia-Reyero, Kellie Fay, Jon Hamm, Paula Henry, Wesley Hunter, Donna Judkins, Nicole Kleinstreuer, Carlie Lalone, James Laurenson, Jessica Leet, Scott Lynn, Teresa Norberg-King, Edward Odenkirchen, Elijah Petersen, Barnett Rattner, Catherine Sprankle, Thomas Steeger, Jim Warren, Sarah Winfield
U.S. regulatory and research agencies utilize ecotoxicity test data to assess the hazards associated with substances that are released into the environment, including consumer products, industrial chemicals, metals and metalloids, nanomaterials, and

IVIVE: Facilitating the use of in vitro toxicity data in risk assessment and decision making

May 1, 2022
Xiaoqing Chang, Yu-Mei Tan, David Allen, Shannon Bell, Paul Brown, Lauren Browning, Patricia Ceger, Jeffery Gearhart, Pertti Hakkinen, Shruti Kabadi, Nicole Kleinstreuer, Annie Lumen, Joanna Matheson, Alicia Paini, Heather Pangburn, Elijah Petersen, Emily Reinke, Alexandre Ribeiro, Nisha Sipes, Lisa Sweeney, John Wambaugh, Ronald Wange, Barbara Wetmore, Moiz Mumtaz
During the past few decades, the science of toxicology has been undergoing transformation from an observational to a predictive science. New approach methodologies (NAMs) including in vitro, in silico models, read across, and in vitro to in vivo

Current Nanomaterials Toxicity Testing Needs and Use of New Approach Methodologies Among Selected U.S. Federal Agencies

April 11, 2022
Elijah Petersen, Patricia Ceger, Jayme Coyle, David Allen, Raymond Derk, Natalia Garcia-Reyero, John Gordon, Nicole Kleinstreuer, Joanna Matheson, Danielle McShan, Bryant C. Nelson, Anil Patri, Liying Rojanasakul, Abhilash Sasidharan, Louis Scarano, Xiaoqing Chan
Engineered nanomaterials (ENMs) come in a wide array of shapes, sizes, surface coatings, and compositions, and often possess novel or enhanced properties compared to larger sized particles of the same elemental composition. To ensure the safe

Characteristics to Consider when Selecting a Positive Control Material for an In Vitro Assay

September 29, 2021
Elijah Petersen, Andrew Nguyen, Jeffrey Brown, John T. Elliott, Amy Clippinger, John Gordon, Nicole Kleinstreuer, Matthias Roesslein
The use of in vitro assays to inform decision-making requires robust and reproducible results across studies, laboratories, and time. Experiments using positive control materials are an integral component of an assay procedure to demonstrate the extent to

Parametric optimization of an air-liquid interface system for flow through inhalation exposure to nanoparticles: assessing dosimetry and intracellular uptake of CeO2 nanoparticles

September 29, 2021
Lars Leibrock, Harald Jungnickel, Jutta Tentschert, Aaron Katz, Blaza Toman, Elijah Petersen, Frank Bierkandt, Ajay V. Singh, Peter Laux, Andreas Luch
Air-liquid interface (ALI) systems have been widely used in recent years to investigate the inhalation toxicity of many gaseous compounds, chemicals, and nanomaterials and represent an emerging and promising in vitro method to supplement or ultimately

Resources for developing reliable and reproducible in vitro test methods

September 29, 2021
Elijah Petersen, Vytas Reipa, Menghang Xia, Monita Sharma
A broad range of in vitro test methods have been developed given their numerous potential advantages over in vivo tests. We describe here key resources and tools to increase the reliability and reproducibility of in vitro test methods.

Use of cause-and-effect analysis to optimize the reliability of in vitro inhalation toxicity measurements using an air-liquid interface

September 29, 2021
Elijah Petersen, Monita Sharma, Amy Clippinger, John Gordon, Aaron Katz, Peter Laux, Lars Leibrock, Andreas Luch, Joanna Matheson, Andreas Stucki, Jutta Tentschert, Frank Bierkandt
In vitro inhalation toxicology methods are increasingly being used for research and regulatory purposes. While the opportunity for increased human relevance of in vitro inhalation methods compared to in vivo tests has been established and discussed, how to

Comparative study of multiwall carbon nanotube nanocomposites by Raman, SEM, and XPS measurement techniques

March 3, 2021
Yanmei Piao, Vipin Tondare, Chelsea S. Davis, Justin Gorham, Elijah Petersen, Jeffrey W. Gilman, Keana Scott, Andras Vladar, Angela R. Hight Walker
Substantial ongoing research efforts are investigating the production of novel composite material enhanced by the incorporation of nanomaterial fillers such as multiwall carbon nanotubes (MWCNTs). While the addition of MWCNTs have been shown to improve the

Harmonizing Across Environmental Nanomaterial Testing Media for Increased Comparability of Nanomaterial Datasets

November 8, 2019
Nicholas Geitner, Christine O. Hendren, Geert Cornelis, Ralf Kaegi, Jamie Lead, Gregory Lowry, Iseult Lynch, Bernd Nowack, Elijah Petersen, Emily Bernhardt, Scott Brown, Warren Chan, Camille de Garidel-Thoron, Jaydee Hanson, Stacey Harper, Kim Jones, Frank von der Kammer, Alan Kennedy, Justin Kidd, Cole Matson, Christopher Metcalf, Joel Pedersen, Willie Peijnenburg, Joris Quik, Sonia Rodriguez, Jerome Rose, Phil Sayre, Marie Simonin, Claus Svendsen, Robert Tanguay, Nathalie Tukenji, Tom van Teunenbroek, Gregory Thies, Yuan Tian, Jacelyn Rice, Jie Liu, Jason Unrine, Marina Vance, Jason White, Mark Wiesner
The chemical composition and properties of environmental media play defining roles in determining nanomaterial (NM) transport, fate, biouptake, and even organism response. To compare and interpret experimental data, it is essential that sufficient context

Determining what really counts: Modeling and measuring nanoparticle number concentrations

August 1, 2019
Elijah J. Petersen, Antonio R. Montoro Bustos, Blaza Toman, Monique E. Johnson, Mark Ellefson, George C. Caceres, Anna Lena Neuer, Qilin Chan, Jonathan Kemling, Brian Mader, Karen E. Murphy, Matthias Roesslein
Elijah J. Petersen, Antonio Montoro Bustos, Blaza Toman, Monique Johnson, Mark Ellefson, George C. Caceres, Anna Lena Neuer, Qilin Chan, Jonathan Kemling, Brian Mader, Karen Murphy, Matthias Roesslein

Towards Sustainable Environmental Quality: Priority Research Questions for North America

July 30, 2019
Anne Fairbrother, Derek Muir, Keith Solomon, Gerald Ankley, Murray Rudd, Alistair Boxall, William Adams, Jennifer Apell, Bonnie Blalock, Sarah Bowman, Linda Campbell, George Cobb, Kristin Connors, David Dreier, Marlene Evans, Carol Henry, Robert Hoke, Magali Houde, Stephen Klaine, Rebecca Klaper, Sigrun Kullik, Roman Lanno, Charles Meyer, Elias Oziolor, Mary Ann Ottinger, Elijah Petersen, Helen Poynton, Pamela Rice, Gabriela Rodriguez-Fuentes, Alan Samel, Joseph Shaw, Jeffrey Steevens, Tim Verslycke, Scott Weir, Peter Wilson, Bryan Brooks
Anticipating, identifying and prioritizing strategic needs represent essential activities by research organizations. When these pursuits engage globally important environment and health goals, including the United Nations Sustainable Development Goals

Strategies for robust and accurate measurement of nanomaterial bioaccumulation

April 17, 2019
Elijah J. Petersen, Monika Mortimer, Robert Burgess, Richard Handy, Shannon Hanna, Kay Ho, Monique E. Johnson, Susana Louriero, Selck Henriette, Janeck Scott-Fordsmand, David Spurgeon, Jason Unrine, Nico van den Brink, Ying Wang, Jason White, Patricia Holden
One of the key components for environmental risk assessment of engineered nanomaterials (ENMs) is data on bioaccumulation potential. Accurately measuring bioaccumulation can be critical for regulatory decision making regarding material hazard and risk, and

Agglomeration of Escherichia coli with positively charged nanoparticles can lead to artifacts in a standard Caenorhabditis elegans toxicity assay

April 19, 2018
Shannon Hanna, Antonio Montoro Bustos, Alexander W. Peterson, Vytas Reipa, Leona D. Scanlan, Sanem Hosbas Coskun, Tae Joon Cho, Monique Johnson, Vincent A. Hackley, Bryant C. Nelson, Michael R. Winchester, John T. Elliott, Elijah Petersen
The increased use and incorporation of engineered nanoparticles (ENPs) in consumer products requires a robust assessment of their potential environmental implications. However, a lack of standardized methods for nanotoxicity testing has yielded results

Detection and Quantification of Graphene Family Nanomaterials in the Environment

March 5, 2018
David Goodwin, Adeyemi Adeyele, Li Piin Sung, Kay Ho, Robert Burgess, Elijah Petersen
An increase in production of commercial products containing graphene-family nanomaterials (GFNs) has led to concern over their release into the environment. The fate and potential ecotoxicological effects of GFNs in the environment are currently unclear

Counting Caenorhabditis elegans: Protocol Optimization and Applications for Population Growth and Toxicity Studies in Liquid Medium

January 17, 2018
Steven Lund, Sanem Hosbas Coskun, Monique Johnson, Christopher Sims, Elijah Petersen, John T. Elliott, Bryant C. Nelson, Leona D. Scanlan, Shannon K. Hanna, Karina Brignoni, Patricia Lapasett
The nematode Caenorhabditis elegans is used extensively in molecular, toxicological and genetics research. However, standardized methods for counting nematodes in liquid culture do not exist despite the wide use of nematodes and need for accurate

Sucrose density gradient centrifugation for efficient separation of engineered nanoparticles from a model organism, Caenorhabditis elegans

October 11, 2017
Monique E. Johnson, Antonio R. Montoro Bustos, Elijah J. Petersen, Shannon K. Hanna, Karen E. Murphy, Lee L. Yu, Bryant C. Nelson, Michael R. Winchester
This protocol describes a strategy for separating Caenorhabditis elegans (C. elegans) from engineered nanomaterials, a critical step for accurate quantification in uptake studies. Conventional rinsing procedures, typically comprised of water or buffer

Multiple method analysis of TiO2 nanoparticles uptake, accumulation and effects in rice (Oryza sativa L.) plants

August 4, 2017
Yinqging Deng, Elijah Petersen, Katie Challis, Savelas A. Rabb, Richard D. Holbrook, James Ranville, Bryant C. Nelson, Baoshan Xing
Understanding the translocation of nanoparticles (NPs) into plants is challenging because quantitative and qualitative methods are still being developed and the comparability of results among different methods is unclear. In this study, the uptake of NPs