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Current Ecotoxicity Testing Needs Among Selected U.S. Federal Agencies



Patricia Ceger, David Allen, Elyssa Arnold, Jennifer Brennan, Lyle Burgoon, Raanan Bloom, Carol Clarke, Natalia Garcia-Reyero, Kellie Fay, Jon Hamm, Paula Henry, Wesley Hunter, Donna Judkins, Nicole Kleinstreuer, Carlie Lalone, James Laurenson, Jessica Leet, Scott Lynn, Teresa Norberg-King, Edward Odenkirchen, Elijah Petersen, Barnett Rattner, Catherine Sprankle, Thomas Steeger, Jim Warren, Sarah Winfield


U.S. regulatory and research agencies utilize ecotoxicity test data to assess the hazards associated with substances that are released into the environment, including consumer products, industrial chemicals, metals and metalloids, nanomaterials, and pesticides. These data are evaluated to ensure that such substances will not cause unreasonable adverse effects to invertebrates, fish, birds, or other wildlife species. The U.S. Department of Defense, the U.S. Department of the Interior, the U.S. Environmental Protection Agency, the U.S. Food and Drug Administration, the National Institute for Standards and Technology, and the U.S. Department of Agriculture are member agencies of the ecotoxicity workgroup (EcoWG) of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). ICCVAM seeks to identify opportunities for the use of non-animal replacements to satisfy testing needs and requirements. This review, authored by the EcoWG, identifies the standards, test guidelines, or guidance documents that are applicable to satisfy each of these agency's needs, common test species, and endpoints with regard to ecotoxicity testing. We discuss challenges presented by current use of cross-taxa extrapolation and outline points for consideration in the development of alternative methods.
Regulatory Toxicology and Pharmacology


Ceger, P. , Allen, D. , Arnold, E. , Brennan, J. , Burgoon, L. , Bloom, R. , Clarke, C. , Garcia-Reyero, N. , Fay, K. , Hamm, J. , Henry, P. , Hunter, W. , Judkins, D. , Kleinstreuer, N. , Lalone, C. , Laurenson, J. , Leet, J. , Lynn, S. , Norberg-King, T. , Odenkirchen, E. , Petersen, E. , Rattner, B. , Sprankle, C. , Steeger, T. , Warren, J. and Winfield, S. (2022), Current Ecotoxicity Testing Needs Among Selected U.S. Federal Agencies, Regulatory Toxicology and Pharmacology (Accessed May 21, 2024)


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Created June 2, 2022, Updated October 19, 2022