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Search Publications by: Joseph Robertson (Fed)

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Displaying 1 - 25 of 50

Engineering Nanopore Approaches toward Protein Sequencing

July 25, 2023
Xiaojun Wei, Tadas Penkauskas, Joseph Reiner, Mark Uline, Qian Wang, Sheng Li, Aleksei Aksimentiev, Joseph Robertson, Chang Liu
Biotechnological innovations have vastly improved the capacity to perform large-scale protein studies, while the methods we have of identifying and quantifying individual proteins are still inadequate to perform protein sequencing at the single-molecule

Nanopore sensing: a physical-chemical approach

September 1, 2021
Joseph W. Robertson, Madhav Ghimire, Joseph Reiner
Protein nanopores have emerged as an important class of sensor, for the understanding of biophysical processes, such as molecular transport across membranes, and detection and characterization of biopolymers. We trace the development of these sensors from

Nonvolatile memory based on redox-active Ruthenium molecular monolayers

October 14, 2019
Kai Jiang, Sujitra Pookpanratana, Tong Ren, Sean Natoli, Brent A. Sperling, Joseph W. Robertson, Curt A. Richter, Sheng Yu, Qiliang Li
A monolayer of diruthenium molecules was self-assembled onto the silicon oxide surface in a semiconductor capacitor structure with a ‘click' reaction for nonvolatile memory applications. The attachment of the active molecular monolayer was verified by x

A Comparison of Ion Channel Current Blockades Caused by Individual Poly(ethylene glycol) Molecules and Polyoxometalate Nanoclusters

June 28, 2019
Haiyan Wang, John J. Kasianowicz, Joseph W. Robertson, Dianne L. Poster, Jessica Ettedgui
Proteinaceous nanometer-scale pores have been used to detect and physically characterize many different types of molecules at the single molecule limit. The method is based on the ability to measure the transient reduction in the ionic channel conductance

High Resolution Physical Characterization of Single Metallic Nanoparticles

June 28, 2019
Jessica Ettedgui, Jacob Forstater, Joseph W. Robertson, John J. Kasianowicz
Discrete metal oxygen clusters, polyoxometalates (POMs), can be detected at the single molecule limit, using a biological nanopore-based electronic platform. The method provides a complementary approach to traditional analytical chemistry tools utilized in

Determining the physical properties of molecules with nanometer-scale pores

January 30, 2018
Haiyan Wang, Jessica Ettedgui, Jacob Fortater, Joseph W. Robertson, Joseph Reiner, Huisheng Zhang, Siping Chen, John J. Kasianowicz
Nanometer-scale pores have recently been developed for the detection, characterization, and quantitation of a wide range of analytes (e.g., ions, polymers, proteins, anthrax toxins, neurotransmitters, and synthetic nanoparticles), and for DNA sequencing

Novel Nanofluidic Chemical Cells based on Self-Assembled Solid-State SiO2 Nanotubes

August 30, 2017
Hao Zhu, Haitao Li, Arvind Balijepalli, Joseph W. Robertson, Sergiy Krylyuk, Albert Davydov, John J. Kasianowicz, John S. Suehle, Qiliang Li
Novel nanofluidic chemical cells based on self-assembled solid-state SiO2 nanotubes on silicon- on-insulator (SOI) substrates have been successfully fabricated and tested. The vertical SiO2 nanotubes with a smooth cavity are built from Si nanowires which

Integration of Redox-Active Diruthenium-based Molecular Layer onto Electrodes for Memory Device Applications

November 10, 2016
Sujitra J. Pookpanratana, Hao Zhu, Joseph W. Robertson, Sean Natoli, Emily G. Bittle, Curt A. Richter, Tong Ren, Qiliang Li, Christina A. Hacker
Attaching and integrating electrochemically-active molecules to a variety of different surfaces is of importance for applications in catalysis, memory devices, and molecular electronics. With the increasing demand for personal electronics, growth in Flash

MOSAIC: A Modular Single Molecular Analysis Interface for Decoding Multi-state Nanopore Data

October 31, 2016
Jacob H. Forstater, Kyle Briggs, Joseph W. Robertson, Jessica H. Benjamini, Olivier M. Marie-Rose, Canute I. Vaz, John J. Kasianowicz, Vincent Tabard-Cossa, Arvind Balijepalli
Single molecule measurements with nanometer-scale pores are being developed for a wide range of diagnostic and therapeutic applications.  Critical to the method is the ability to accurately and precisely detect the presence of an analyte, quantify its

Attachment of a Reduction-Oxidative Active Diruthenium Compound to Au and Si Surfaces by “Click” Chemistry

August 10, 2014
Sujitra J. Pookpanratana, Joseph W. Robertson, Curt A. Richter, Christina A. Hacker, Lee J. Richter, Julia Savchenko, Steven Cummings, Tong Ren
We report the formation of molecular monolayers containing redox-active diruthenium(II,III) compound to gold and silicon surfaces via “click” chemistry. The use of Cu-catalyzed azide-alkyne cycloaddition enables modular design of molecular surfaces and

Quantifying short-lived events in multistate ionic current measurements

January 7, 2014
Arvind K. Balijepalli, Jessica H. Benjamini, Andrew T. Cornio, Joseph W. Robertson, Kin P. Cheung, John J. Kasianowicz, Canute I. Vaz
We developed a generalized technique to characterize polymer!nanopore interactions via single channel ionic current measurements. Physical interactions between analytes, such as DNA, proteins, or synthetic polymers, and a nanopore cause multiple discrete

Temperature sculpting in yoctoliter volumes

February 14, 2013
Joseph E. Reiner, Joseph W. Robertson, Daniel L. Burden, Lisa K. Burden, Arvind Balijepalli, John J. Kasianowicz
The ability to perturb large ensembles of molecules from equilibrium led to major advances in understanding reaction mechanisms in chemistry and biology. Here, we demonstrate the ability to control, measure, and make use of rapid temperature changes of


January 30, 2013
Sujitra J. Pookpanratana, Joseph W. Robertson, Cherno Jaye, Daniel A. Fischer, Curt A. Richter, Christina A. Hacker
We have used Flip Chip Lamination (FCL) to form monolayer and bilayer molecular junctions of carboxylic acid-containing molecules with Cu atom incorporation. Carboxylic acid-terminated monolayers are self-assembled onto ultrasmooth Au using thiol chemistry

The Effects of Diffusion on an Exonuclease/Nanopore-Based DNA Sequencing Engine

December 7, 2012
Joseph E. Reiner, Joseph W. Robertson, Arvind Balijepalli, Daniel L. Burden, Bryon S. Drown, John J. Kasianowicz
The ability to electronically detect and characterize individual polynucleotides as they are driven through a single protein ion channel may eventually prove useful for rapidly sequencing DNA (base-by-base) in a ticker tape-like fashion. More recently, a