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Search Publications by: Darwin Reyes-Hernandez (Fed)

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Displaying 1 - 25 of 53

Overcoming Technological Barriers in Microfluidics: Leakage Testing

September 1, 2022
Vania Silverio, Suvajyoti Guha, Armelle Keiser, Rucha Natu, Darwin Reyes-Hernandez, Henne van Heeren, Nicolas Verplanck, Luke Herbertson
The miniaturization of laboratory procedures for Lab-on-Chip (LoC) devices and translation to various platforms such as single cell analysis or Organ-on-Chip (OoC) systems are revolutionizing the life sciences and biomedical fields. As a result

Protocols for leakage testing

June 1, 2022
Henne van Heeren, Matthew Davies, Armelle Keiser, Rudy Lagrauw, Darwin Reyes-Hernandez, Vania Silverio, Nicolas Verplanck
This document is written to serve as a guideline for the testing of microfluidic devices, which are devices designed to manipulate fluids that are confined in a small volume. For instance, a channel with at least one dimension smaller than 1 mm is a

Amontons-Coulomb-like slip dynamics in acousto-microfluidics

March 22, 2022
Aurore F. Quelennec, Jason J. Gorman, Darwin Reyes-Hernandez
Electroacoustic technologies, which employ acoustic waves to manipulate and detect bioparticles, have been increasingly used, with a great deal of success, in life sciences. Particle manipulation or measurement capabilities of surface acoustic wave-based

Accelerating Innovation and Commercialization Through Standardization of Microfluidic-Based Medical Devices

January 5, 2021
Darwin R. Reyes-Hernandez, Henne van Heeren, Suvajyoti Guha, Luke Herbertson, Alexios P. Tzannis, Jens Ducr?e, Hugo Bissig, Holger Becker
The microfluidics industry has grown steadily over the last 5 years worldwide, with the market for microfluidic medical devices experiencing a compound growth rate of 18%. The number of submissions to regulatory agencies such as the U.S. Food & Drug

Frequency tunable label-free surface acoustic wave-based flow sensor

October 7, 2020
Aurore F. Quelennec, Jason J. Gorman, Darwin Reyes-Hernandez
We present a label-free SAW-based flow sensor with enhanced precision and repeatability. This sensor improves the signal-to-noise ratio by one order of magnitude (dB scale) at an optimized frequency, and lowers the measurable flow rate to 5 μL/min (from

Label-free surface acoustic wave-based embedded flow sensor

October 27, 2019
Aurore F. Quelennec, Jason J. Gorman, Darwin Reyes-Hernandez
This paper presents a calibration/label-free flow sensor embedded in a microfluidic system. This sensor is based on surface acoustic waves, where the acoustic intensity is dependent on the flow rate of the propagating medium. The range of flow rates

Live quantification of cell viability via neutral red uptake using lens-free imaging

October 27, 2019
Brian J. Nablo, Jungjoon Ahn, Kiran Bhadriraju, Jong M. Lee, Darwin Reyes-Hernandez
We present the quantification of cell viability during neutral red (NR) uptake with a compact lens-free system utilizing two light sources. Conventionally, the NR uptake assay determines cell viability based on the accumulation of NR within lysosomes and

Proceedings of the First Workshop on Standards for Microfluidics

January 28, 2019
Darwin R. Reyes-Hernandez, Henne van Heeren
In the last two decades, the microfluidics/lab-on-a-chip field has evolved from the concept of micro total analysis systems, where systems with integrated pretreatment and analysis of chemicals were envisioned, to what is known today as lab-on-a-chip

The 2016 edition of the Art in Science of MicroTAS

April 21, 2017
Darwin R. Reyes-Hernandez
Dublin, Ireland beheld The 20th International Conference of Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) from October 23 to 27, 2016. The conference not only included a great technical program, but also outreach activities, an


October 9, 2016
Pengfei Niu, Brian J. Nablo, Kiran Bhadriraju, Darwin Reyes-Hernandez
Here we present conclusive proof that when using electrical impedance to measure volumetric flow rate in polydimethylsiloxane (PDMS) microchannels a considerable fraction of the change in impedance, due to change in flow rate, is caused by the variation in

The Art in Science of MicroTAS: the 2014 issue

April 14, 2015
Darwin R. Reyes-Hernandez
For the 7th year in a row the Art in Science award competition, sponsored by Lab on a Chip and the National Institute of Standards and Technology (NIST), took place at the 18th International Conference of Miniaturized Systems for Chemistry and Life

Polyelectrolyte Multilayers in Microfluidic Systems for Biological Applications

July 31, 2014
Saugandhika S. Minnikanti, Aveek Gangopadhyay, Darwin Reyes-Hernandez
The formation of polyelectrolyte multilayers (PEMs) for the first time two decades ago demonstrating the assembly on charged substrates in a very simple and efficient way have proven to be a reliable method to obtain structures tunable at the nanometer