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Search Publications by: Wyatt N. Vreeland (Fed)

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Displaying 26 - 45 of 45

Liposome-Templated Supramolecular Assembly of Responsive Alginate Nanogels

March 14, 2008
Jennifer S. Hong, Wyatt N. Vreeland, Silvia H. De Paoli Lacerda, Laurie E. Locascio, Michael Gaitan, Srinivasa R. Raghavan
Nanosized gel particles (nanogels) are of interest for a variety of applications, including controlled release of drugs and single-molecule encapsulation. Here, we employ the cores of nanoscale liposomes as reaction vessels to template the assembly of

Preparation of Nanoparticles by Continuous-Flow Microfluidics

February 15, 2008
Andreas Jahn, Joseph E. Reiner, Wyatt N. Vreeland, Don DeVoe, Laurie E. Locascio, Michael Gaitan
We review a variety of micro- and nanoparticle formulations produced with microfluidic methods. A diverse variety of approaches to generate micro-scale and nano-scale particles have been reported. Here we emphasize the use of microfluidics, specifically

Microfluidic Directed Formation of Liposomes of Controlled Size

April 24, 2007
Andreas Jahn, Wyatt N. Vreeland, Don DeVoe, Laurie E. Locascio, Michael Gaitan
A new method to tailor liposome size and size distribution in a microfluidic format is presented. Liposomes are spherical structures formed from lipid bilayers that are from tens of nanometers to several micrometers in diameter. Liposome size and size

Scanning Temperature Gradient Focusing

August 2, 2006
S J. Hoebel, K M. Balss, Barbara J. Jones, C Malliaris, Matt S. Munson, Wyatt N. Vreeland, David J. Ross
Temperature gradient focusing (TGF) is a recently developed technique for the simultaneous concentration and electrophoretic separation of ionic analytes in microfluidic channels. One drawback to TGF as it has previously been described is the limited peak

Capillarity Induced Solvent?Actuated Bonding of Polymeric Microfluidic Devices

April 12, 2006
Jayna J. Shah, Jon C. Geist, Laurie E. Locascio, Michael Gaitan, Rao Mulpuri, Wyatt N. Vreeland
Rapid, robust and economical fabrication of fluidic microchannels is of fundamental importance for the successful development of disposable lab-on-a-chip devices. In this work, we present a solvent-actuated bonding method for fabricating polymeric

Liposomes As Model Cellular Systems

December 21, 2004
Laurie E. Locascio, Wyatt N. Vreeland, Andreas Jahn, Michael Gaitan
The discovery that phospholipids spontaneously form fluid-filled bubbles when exposed to aqueous solution was first made by Alec Bangham in the early 1960's while studying the effects of phospholipids on blood clotting in the Babraham Institute in England

Controlled Vesicle Self-Assembly in Continuous Two Phase Flow Microfluidic Channels

June 10, 2004
Andreas Jahn, Wyatt N. Vreeland, Laurie E. Locascio, Michael Gaitan
The spontaneous self-assembly of phospholipids into liposomes in aqueous solution results in the encapsulation of reagents into quantized packets in a manner that mimics cellular life-processes. Since their discovery in 1965, liposomes have been used in a

Chiral Separations by Temperature Gradient Focusing

February 1, 2004
K M. Balss, Wyatt N. Vreeland, Karen W. Phinney, Michael J. Tarlov, David J. Ross
Temperature gradient focusing (TGF) involves application of a temperature gradient across a microchannel or capillary. With an appropriate buffer, the temperature gradient creates a gradient in both the electric field and the electrophoretic velocity