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Displaying 1 - 25 of 164

Models for an Ultraviolet-C Research and Development Consortium

March 25, 2022
Author(s)
Dianne L. Poster, C Cameron Miller, Yaw S. Obeng, John J. Kasianowicz, Michael T. Postek, Norman Horn, Troy Cowan, Richard Martinello
The development of an international, precompetitive, collaborative, ultraviolet (UV) research consortium is discussed as an opportunity to lay the groundwork for a new UV commercial industry and the supply chain to support this industry. History has

Solution Structures of Bacillus Anthracis Protective Antigen Proteins using Small Angle Neutron Scattering and Protective Antigen 63 Ion Channel Formation Kinetics

December 11, 2021
Author(s)
Ariel Michelman-Ribeiro, Kenneth A. Rubinson, Vitalii Silin, John J. Kasianowicz
We are studying the structures of bacterial toxins that form ion channels and catalyze macromolecule transport across membranes. For example, the crystal structure of the Staphylococcus aureus α-hemolysin (α-HL) channel in its functional state was

Anthrax Toxin Functional Assay: Lethal Factor Binding to Protective Antigen Ion Channel

October 12, 2021
Author(s)
Kelly Halverson, R G. Panchal, T L. Nguyen, S Little, Martin Misakian, Sina Bavari, John J. Kasianowicz
Bacillus anthracis secretes three toxins (protective antigen, PA; lethal factor, LF; and edema factor, EF) that are the molecular basis of anthrax-induced cell death. We studied the functional interaction between LF and activated PA (PA63) in planar

Molecular-scale Structural and Functional Characterization of Sparsely Tethered Bilayer Membranes

October 12, 2021
Author(s)
Duncan McGillivray, Gintaras Valincius, David J. Vanderah, W Febo-Ayala, John T. Woodward IV, F Hienrich, John J. Kasianowicz, M Losche
Surface-tethered biomimetic bilayer membranes (tethered lipid bilayer membranes, tBLMs) have been formed on gold surfaces from phospholipids and a synthetic 1-thiahexa(ethy lene oxide) lipid, WC14. They have been characterized using electrochemical

The Mitochondrial Apoptosis-Induced Channel MAC and Bax Channels Are Regulated by Cytochrome C

October 12, 2021
Author(s)
Li Guo, D Pietkiewicz, M M. Pavlov, John J. Kasianowicz, L M. Dejean, S J. Korsmeyer, B Antonsson, K W. Kinnally
l-2 family proteins regulate the appearance of the high-conductance channel MAC (mitochondrial apoptosis-induced channel) 1 in the outer membranes of mitochondria early in apoptosis and regulate the release of cytochrome c during commitment to apoptosis

Ultraviolet Radiation Technologies and Healthcare Associated Infections: Standards and Metrology Needs

August 20, 2021
Author(s)
Dianne L. Poster, C Cameron Miller, Richard Martinello, Norman Horn, Michael T. Postek, Troy Cowan, Yaw S. Obeng, John J. Kasianowicz
The National Institute of Standards and Technology (NIST) hosted an international workshop on ultraviolet-C (UV-C) disinfection technologies on January 14 – 15, 2020 in Gaithersburg, Maryland in collaboration with the International Ultraviolet Association

A Comparison of Ion Channel Current Blockades Caused by Individual Poly(ethylene glycol) Molecules and Polyoxometalate Nanoclusters

June 28, 2019
Author(s)
Haiyan Wang, John J. Kasianowicz, Joseph W. Robertson, Dianne L. Poster, Jessica Ettedgui
Proteinaceous nanometer-scale pores have been used to detect and physically characterize many different types of molecules at the single molecule limit. The method is based on the ability to measure the transient reduction in the ionic channel conductance

High Resolution Physical Characterization of Single Metallic Nanoparticles

June 28, 2019
Author(s)
Jessica Ettedgui, Jacob Forstater, Joseph W. Robertson, John J. Kasianowicz
Discrete metal oxygen clusters, polyoxometalates (POMs), can be detected at the single molecule limit, using a biological nanopore-based electronic platform. The method provides a complementary approach to traditional analytical chemistry tools utilized in

Determining the physical properties of molecules with nanometer-scale pores

January 30, 2018
Author(s)
Haiyan Wang, Jessica Ettedgui, Jacob Fortater, Joseph W. Robertson, Joseph Reiner, Huisheng Zhang, Siping Chen, John J. Kasianowicz
Nanometer-scale pores have recently been developed for the detection, characterization, and quantitation of a wide range of analytes (e.g., ions, polymers, proteins, anthrax toxins, neurotransmitters, and synthetic nanoparticles), and for DNA sequencing

Novel Nanofluidic Chemical Cells based on Self-Assembled Solid-State SiO2 Nanotubes

August 30, 2017
Author(s)
Hao Zhu, Haitao Li, Arvind Balijepalli, Joseph W. Robertson, Sergiy Krylyuk, Albert Davydov, John J. Kasianowicz, John S. Suehle, Qiliang Li
Novel nanofluidic chemical cells based on self-assembled solid-state SiO2 nanotubes on silicon- on-insulator (SOI) substrates have been successfully fabricated and tested. The vertical SiO2 nanotubes with a smooth cavity are built from Si nanowires which

MOSAIC: A Modular Single Molecular Analysis Interface for Decoding Multi-state Nanopore Data

October 31, 2016
Author(s)
Jacob H. Forstater, Kyle Briggs, Joseph W. Robertson, Jessica H. Benjamini, Olivier M. Marie-Rose, Canute I. Vaz, John J. Kasianowicz, Vincent Tabard-Cossa, Arvind Balijepalli
Single molecule measurements with nanometer-scale pores are being developed for a wide range of diagnostic and therapeutic applications.  Critical to the method is the ability to accurately and precisely detect the presence of an analyte, quantify its
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