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Displaying 901 - 925 of 2355

Addiction to MTH1 protein results in intense expression in human breast cancer tissue as measured by liquid chromatography-isotope-dilution tandem mass spectrometry

June 23, 2015
Author(s)
Erdem Coskun, Pawel Jaruga, Ann-Sofie Jemth, Olga Loseva, Leona D. Scanlan, Alessandro Tona, Mark S. Lowenthal, Thomas Helleday, M Miral Dizdar
MTH1 protein sanitizes the nucleotide pool so that modified 2'-deoxynucleoside triphosphates (dNTPs) cannot be used in DNA replication. Cancer cells require MTH1 to avoid incorporation of modified dNTPs resulting in DNA damage mutations and cell death

Histone H3 Ser57 and Thr58 Phosphorylation in 5XFAD Mouse Brain

June 20, 2015
Author(s)
Kyle W. Anderson, Illarion V. Turko, Natalia Mast, Irina A. Pikuleva
Alzheimer’s disease (AD) is the most common neurodegenerative disorder, yet it is poorly understood. Currently, there is no treatment to delay onset or slow progression of AD. Epigenetics of AD is a growing field that has gained interest due to the

Performance of a next generation sequencing SNP assay on degraded DNA

May 27, 2015
Author(s)
Katherine Gettings, Kevin M. Kiesler, Peter Vallone
Forensic DNA casework samples are often of insufficient quantity or quality to generate full profiles by conventional DNA typing methods. Amplification of STR loci is inherently limited in samples containing degraded DNA, as the cumulative size of repeat

Quantitative scheme for full-field polarization rotating fluorescence microscopy (PROM) using a liquid crystal variable retarder

May 14, 2015
Author(s)
John F. Lesoine, Ji Y. Lee, Hyeong G. Kang, Matthew L. Clarke, Robert C. Chang, Ralph Nossal, Jeeseong C. Hwang
We introduce real-time, full-field, polarization rotating fluorescence microscopy (PROM) to monitor the absorption dipole orientations of fluorescent molecules. A quarter-wave plate, in combination with a liquid crystal variable retarder (LCVR), provides a

New night vision goggle gain definition

May 12, 2015
Author(s)
Vyacheslav B. Podobedov, George P. Eppeldauer, Thomas C. Larason
A new definition is proposed for the calibration of Night Vision Goggle (NVG) gains. This definition is based on the measurement of radiometric input and output quantities of the NVG. While the old definition used the “equivalent fL” which is a non SI

Validated Open Source Nanofiber Diameter Measurement Tool

April 30, 2015
Author(s)
Nathan A. Hotaling, Kapil Bharti, Haydn Kriel, Carl G. Simon Jr.
Despite the growing use of nanofiber scaffolds for tissue engineering applications, there is not a validated, readily available (commercial or open source) solution for rapid, automated analysis of nanofiber diameter from scanning electron microscope (SEM)

The Art in Science of MicroTAS: the 2014 issue

April 14, 2015
Author(s)
Darwin R. Reyes-Hernandez
For the 7th year in a row the Art in Science award competition, sponsored by Lab on a Chip and the National Institute of Standards and Technology (NIST), took place at the 18th International Conference of Miniaturized Systems for Chemistry and Life
Displaying 901 - 925 of 2355
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