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Neutron research

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Displaying 851 - 875 of 1584

Insertion of Dengue E into Lipid Bilayers Studied by Neutron Reflectivity Molecular Dynamics Simulations

February 13, 2018
Author(s)
Juan M. Vanegas, Frank Heinrich, David M. Rogers, Bryan D. Carson, Sadie La Bauve, Briana C. Vernon, Sushil K. Satija, Aihua Zheng, Margaret Kielian, Susan B. Rempe, Michael S. Kent
The envelope (E) protein of Dengue virus rearranges to a trimeric hairpin to mediate fusion of the viral and target membranes, which essential for infectivity. Insertion of E into the target membrane serves to anchor E and possibly also to disrupt local

Beyond Catalysis and Membranes: Visualizing and Solving the Electrode Water Challenge in AEMFCs

February 8, 2018
Author(s)
Daniel S. Hussey, Travis J. Omasta, Andrew M. Park, Jacob M. LaManna, Yufeng Zheng, Xiong Peng, Lianqin Wang, David L. Jacobson, John R. Varcoe, Bryan S. Pivovar, William E. Mustain
A majority of anion exchange membrane fuel cells (AEMFCs) reported in the literature have been unable to achieve high current or power. A recently proposed theory is that the achievable current is largely limited by poorly balanced water during cell

Investigation of Alteration of Li-6 Enriched Neutron Shielding Glass

January 31, 2018
Author(s)
Jamie Weaver, Danyal J. Turkoglu
Silicate glass doped with 6Li is a common slow neutron shielding material, and has been utilized as such in several neutron research facilities. 6Li is a unique isotope for thermal neutron capture as it has a large thermal neutron capture cross section (≈

Nuclear Magnetic Resonance Study of Anion and Cation Reorientational Dynamics in (NH 4 ) 2 B 12 H 12

January 29, 2018
Author(s)
Alexander V. Skripov, Roman V. Skoryunov, Alexei V. Soloninin, Olga A. Babanova, Vitalie Stavila, Terrence J. Udovic
Diammonium dodecahydro-closedidecabirate (NH 4) 2B 12H 12 is the ionic compound combining NH 4 + cations and [B 12H 12] 2- anions both of which can exhibit high reorientational mobility. To study the dynamical properties of this unusual material, we have

Glycerol Hydrogen-Bonding Network Dominates Structure and Collective Dynamics in a Deep Eutectic Solvent

January 25, 2018
Author(s)
Antonio Faraone, Durgesh V. Wagle, Gary A. Baker, E. C. Novak, M. Ohl, D. Reuter, Peter Lunkenheimer, A. Loidl, Eugene Mamontov
The deep eutectic solvent glyceline formed by choline chloride and glycerol in 1:2 molar ratio is much less viscous compared to glycerol, which facilitates its use in many applications where high viscosity is undesirable. Despite the large difference in

H 2 Adsorption on Cu(I)-SSZ-13

January 11, 2018
Author(s)
Bahar Ipek, Rachel A. Pollock, Craig Brown, Deniz Uner, Raul F. Lobo
We report H 2 adsorption capacities reaching 0.05 mass% (wt. %) at 303 K and 1 atm H 2 pressure on solid-state CuCl-exchanged [Al]-SSZ-13 and [B]-SSZ zeolites. Differential heat of H 2 adsorption is found in the range between 16 KJ mol H 2 -1 and 48 KJ mol

Small-Angle X-ray and Neutron Scattering Demonstrates that Cell-Free Expression Produces Properly Formed Disc-Shaped Nanolipoprotein Particles

December 20, 2017
Author(s)
Thomas E Cleveland, Wei He, Angela C. Evans, Nicholas O. Fischer, Matthew A. Coleman, Paul Butler
Nanolipoprotein particles (NLPs), composed of a membrane scaffold protein and lipids, have been used to support membrane proteins in a native-like bilayer environment for biochemical or structural studies. Traditionally, these NLPs have been prepared by

Characterization of Monoclonal Antibody - Protein Antigen Complexes Using Small-Angle Scattering and Molecular Modeling

December 15, 2017
Author(s)
Maria Monica Castellanos Mantilla, James Anthony Snyder, Melody Lee, Srinivas Chakravarthy, Nicholas J. Clark, Arnold McAuley, Joseph E. Curtis
The determination of monoclonal antibody interactions with protein antigens in solution can lead to important insight to guide physical characterization and molecular engineering of therapeutic targets. We used small-angle scattering (SAS) combined with

Spatial Distribution of Hydrophobic Drugs in Model Nanogel-core Star Polymers

December 5, 2017
Author(s)
Vivek M. Prabhu, Guangmin Wei, Robert D. Miller, Victoria A. Piunova, William Swope, Amber Carr
Star polymers with a cross-linked nanogel-core are promising carriers of cargo for therapeutic applications due the synthetic control of amphiphilicity of arms and the stability to infinite dilution. Three nanogel-core star polymers were investigated to

Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway

December 5, 2017
Author(s)
Mark A. Nakasone, Timothy A. Lewis, Olivier Walker, Anita Thakur, Wissam Mansour, Carlos A. Castaneda, Jennifer L. Goeckeler-Fried, Frank Parlati, Tsui-Fen Chou, Ortal Hayat, Daoning Zhang, Christina M. Camara, Steven M. Bonn, Urszula K. Nowicka, Susan T. Krueger, Michael H. Glickman, Jeffrey L. Brodsky, Raymond J. Deshaies, David Fushman
The success of proteasome inhibitors has led to intense efforts to discover points of therapeutic intervention for nearly every component of the ubiquitin-proteasome system. The discovery of ubistatins, small molecules that inhibit proteasomal degradation
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