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Physics

Biological Physics

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Displaying 101 - 125 of 377

A MULTIDIMENSIONAL LANDSCAPE MODEL FOR DETERMINING CELLULAR NETWORK THERMODYNAMICS

March 11, 2020
Author(s)
Joseph B. Hubbard, Michael W. Halter, Anne L. Plant
The distribution of phenotypic responses within an isogenic population of cells reflects the thermodynamics of a stationary state that results from coordinated intracellular reactions. The distribution of phenotypes is the result of both deterministic and

Structure of the cell-binding component of the Clostridium difficile binary toxin reveals a di- heptamer macromolecular assembly

January 14, 2020
Author(s)
Xingjian Xu, Raquel Ruiz, Kaylin Adipietro, Christopher Peralta, Danya Ben-Hail, Kristen Varney, Mary Cook, Braden Roth, Paul Wilder, Thomas Cleveland, Alexander Grishaev, Heather Neu, Sarah Michel, Wenbo Yu, Dorothy Beckett, Richard Rustandi, Alex MacKerell, Amedee des Georges, Edwin Pozharski, David Weber
Targeting Clostridium difficile infection is challenging because treatment options are limited, and high recurrence rates are common. One reason for this is that hypervirulent C. difficile strains often have a binary toxin termed the C. difficile toxin, in

The FeoC [4Fe4S] Cluster Is Redox-Active and Rapidly Oxygen-Sensitive

November 12, 2019
Author(s)
Aaron T. Smith, Richard O. Linkous, Nathan Max, Alexandrea E. Sestok, Veronika Szalai, Kelly N. Chacon
The acquisition of iron is essential to establishing virulence among most pathogens. Under acidic and/or anaerobic conditions, most bacteria utilize the widely-distributed ferrous iron (Fe2+) uptake (Feo) system to import metabolically-required iron. The

Topology, Landscapes, and Biomolecular Energy Transport

October 11, 2019
Author(s)
Justin E. Elenewski, Kirill Velizhanin, Michael P. Zwolak
While ubiquitous, energy redistribution remains a poorly understood facet of the nonequilibrium thermodynamics of biomolecules. At the molecular level, finite-size effects, pronounced nonlinearities, and ballistic processes conspire to produce behavior

Quantum Capacitance-Limited MoS2 Biosensors Enable Remote Label-Free Enzyme Measurements

August 7, 2019
Author(s)
Son T. Le, Nicholas B. Guros, Robert C. Bruce, Antonio Cardone, Niranjana D. Amin, Siyuan Zhang, Jeffery B. Klauda, Harish C. Pant, Curt A. Richter, Arvind Balijepalli
We have demonstrated atomically thin, quantum capacitance-limited, field-effect transistors (FETs) that enable the detection of pH changes with 75-fold higher sensitivity (4.4 V/pH) over the Nernst value of 59 mV/pH at room temperature when used as a

Developing Next-generation Brain Sensing Technologies - A Review

July 22, 2019
Author(s)
Jacob T. Robinson, Eric Pohlmeyer, Malte C. Gather, Caleb Kemere, John Kitching, George G. Malliaras, Adam Marblestone, Kenneth L. Shepard, Thomas Stieglitz, Chong Xie
Advances in sensing technology raise the possibility of creating neural interfaces that can more effectively restore or repair neural function and reveal fundamental properties of neural information processing. To realize the potential of these

Optimal transport and colossal ionic mechano-conductance in graphene crown ethers

July 12, 2019
Author(s)
Subin Sahu, Justin E. Elenewski, Christoph Rohmann, Michael P. Zwolak
Biological ion channels balance electrostatics and hydration, yielding large ion selectivities alongside high transport rates. These macromolecular systems are often interrogated through point mutations of their pore domain, limiting the scope of

A Comparison of Ion Channel Current Blockades Caused by Individual Poly(ethylene glycol) Molecules and Polyoxometalate Nanoclusters

June 28, 2019
Author(s)
Haiyan Wang, John J. Kasianowicz, Joseph W. Robertson, Dianne L. Poster, Jessica Ettedgui
Proteinaceous nanometer-scale pores have been used to detect and physically characterize many different types of molecules at the single molecule limit. The method is based on the ability to measure the transient reduction in the ionic channel conductance

Colloquium: Ionic phenomena in nanoscale pores through 2D materials

June 27, 2019
Author(s)
Subin Sahu, Michael P. Zwolak
Ion transport through channels and nanoscale pores cuts across many disciplines, from single- molecule sensing to pharmacology and cellular physiology to battery and fuel cell technologies. Two-dimensional materials, such as graphene, MoS$_2$, and

Structured Illumination Mueller Matrix Imaging

May 16, 2019
Author(s)
Joseph P. Angelo, Thomas Germer, Maritoni Litorja
We perform Mueller matrix imaging (MMI) of diffusely scattering phantoms under sinusoidal irradiance of varying spatial frequency. Quantitative polarimetric sensing via MMI completely characterizes a sample's polarimetric properties, while structured