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Physics

Biological Physics

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  • Published Date
Displaying 101 - 125 of 197

Single Molecule Nanopore Spectrometry for Peptide Detection

August 15, 2017
Author(s)
Amy Chavis, Joseph Robertson, Joseph E. Reiner, Kyle Brady, Grrace Hatmaker, Nuwan Kothalawala
Sensing and characterization of water-soluble peptides is of critical importance in a wide variety of bioapplications. Single molecule nanopore spectrometry (SMNS) is based on the idea that one can use biological protein nanopores to resolve different

Phosphorylation-induced conformational dynamics in an intrinsically disordered protein and potential role in phenotypic heterogeneity

June 2, 2017
Author(s)
Prakash Kulkarni, Mohit Jolly, Dongya Jia, Steven Mooney, Ajay Bhargava, Luciane Kagohara, Yihong Chen, Pengyu Hao, Yanan He, Roberft Veltri, Alexander Grishaev, Keith Weninger, Herbert Levine, John Orban
Intrinsically disordered proteins (IDPs) that lack a unique 3D structure and comprise a large fraction of the human proteome play important roles in numerous cellular functions. Prostate- Associated Gene 4 (PAGE4) is an IDP that acts as a potentiator of

The 2016 edition of the Art in Science of MicroTAS

April 21, 2017
Author(s)
Darwin R. Reyes-Hernandez
Dublin, Ireland beheld The 20th International Conference of Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2016) from October 23 to 27, 2016. The conference not only included a great technical program, but also outreach activities, an

Broadband spectral measurements of diffuse optical properties by an integrating sphere instrument at the National Institute of Standards and Technology

March 30, 2017
Author(s)
Paul Lemaillet, Jeeseong Hwang, Heidrun Wabnitz, Dirk Grosenick, Lin Yang, David W. Allen
Diffuse materials that approximate the optical properties of human tissue are commonly used as phantoms. In order to use the phantoms in a manner that provides consistent results relative to independent measurements, the optical properties need to be tied

Label-free hyperspectral dark-field microscopy towards quantitative scatter imaging

March 27, 2017
Author(s)
Philip Cheney, David McClatchy III, Stephen Kanick, Paul Lemaillet, David W. Allen, Daniel Samarov, Brian Pogue, Jeeseong C. Hwang
A hyperspectral dark-field microscopy technique has been developed for imaging spatially distributed diffuse reflectance spectra from light-scattering samples. In this report, quantitative scatter spectroscopy was demonstrated with a uniform scattering

Polydimethylsiloxane tissue-mimicking phantoms for quantitative optical medical imaging standards

March 24, 2017
Author(s)
Jeeseong Hwang, Hyun J. Kim, Paul Lemaillet, Dirk Grosenick, Thomas Gladytz, David McClatchy III, Kimberly A. Briggman, Brian Pogue
We report on a procedure to build and characterize solid tissue-mimicking phantoms of polydimethylsiloxane (PDMS) polymers. Controlled inclusion of light scattering titanium dioxide (TiO2) nanoparticles enables the creation of phantoms having tunable light

Direct measurement of Vorticella contraction force by micropipette deflection

February 17, 2017
Author(s)
Danielle C. France, Jonathan Tejada, Paul Matsudaira
The ciliated protozoan Vorticella convallaria is noted for its exceptionally fast ATP-independent cellular contraction, but direct measurements of contractile force have proven difficult given the length scale, speed, and forces involved. We used high

Accuracy of magnetic resonance based susceptibility measurements

February 6, 2017
Author(s)
Hannah E. Erdevig, Stephen E. Russek, Slavka Carnicka, Karl F. Stupic, Kathryn E. Keenan
Magnetic Resonance Imaging (MRI) is increasingly used to map the magnetic susceptibility of tissue to identify cerebral microbleeds associated with traumatic brain injury and pathological iron deposits associated with neurodegenerative diseases such as

Multispectral MR imaging and sensing using shaped nanoparticles

November 26, 2016
Author(s)
Gary Zabow
The idea that size and shape can determine color is well known in optics-based quantum dot and plasmonic nanoparticle fields. But what about in the radio-frequency (RF) portion of the spectrum? This chapter reviews recent work on specially shaped magnetic

Report for Dedicated JPSS VIIRS Ocean Color Calibration/Validation Cruise December 2015

October 30, 2016
Author(s)
Michael Ondrusek, Veronica P. Lance, Eric Stengel, Menghua Wang, Zhongping Lee, Jianwei Wei, Junfang Lin, Chuanmin Hu, Charles Kovach, David English, Jennifer Cannizzaro, Alex Gilerson, Sam Ahmed, Carlos Carrizo, Ahmed El-Habashi, Robert Foster, Matteo Ottaviani, Robert Arnone, Sherwin Ladner, Wesley Goode, Ryan Vandermeulen, Nicholas Tufillaro, Jasmine Nahorniak, Curtiss Davis, Joaquim I. Goes, Kali McKee, Scott Freeman, Joaquin E. Chaves Cedeno, Kenneth Voss, B. Carol Johnson

A medical device-grade T1 and ECV phantom for global T1 mapping quality assurance - The T 1 Mapping and ECV Standardization in cardiovascular magnetic resonance (T1MES) program

September 22, 2016
Author(s)
Gabriella Captur, Peter Gatehouse, Katy Keenan, Friso Heslinga, Ruediger Bruehl, Marcel Prothmann, Martin J. Graves, Richard J. Eames, Camilla Torlasco, Giulia Benedetti, Jacqueline Donovan, Bernd Ittermann, Redha Boubertakh, Andrew Bathgate, Celine Royet, Wenjie Pang, Reza Nezafat, Michael Salerno, Peter Kellman, James C. Moon
Background: T1 mapping and extracellular volume (ECV) have the potential to guide patient care and serve as surrogate end-points in clinical trials, but measurements differ between cardiovascular magnetic resonance (CMR) scanners and pulse sequences. To

Surface plasmon resonance microscopy: achieving a quantitative optical response

September 7, 2016
Author(s)
Alexander Peterson, Michael Halter, Anne Plant, John Elliott
Surface plasmon resonance imaging (SPRI) allows real-time label-free imaging based on index of refraction, and changes in index of refraction at an interface. SPRI can be carried out on a microscope by launching light into a sample, and collecting

Temperature measurements in MRI using ferromagnetic particles

August 9, 2016
Author(s)
Karl F. Stupic, Janusz H. Hankiewicz, Zbigniew Celinski, Robert E. Camley
We explore the possibility of using small ferromagnetic particles with a strong temperature- dependent magnetization to produce temperature maps using magnetic resonance imaging (MRI). We present the first experimental results showing that the 1H nuclear

Real-Time, Single Molecule Electronic DNA Sequencing by Synthesis Using Polymer Tagged Nucleotides on a Nanopore Array

May 10, 2016
Author(s)
Carl Fuller, Shiv Kumar, Mintu Porel, Michen Chien, Arek Bibillo, P. B. Stranges, Michael Dorwart, Chuanjua Tao, Zengmin Li, Wenjing Guo, Shundi Shi, Daniel Korenblum, Andrew Trans, Anne Aguirre, Edward Liu, Takeshi Harada, James Pollard, Ashwini Bhat, Cynthia Cech, Alexander Yang, Cleoma Spilman, Mirko Palla, Jennifer Hovis, Roger Chen, Irina Morozova, Sergey Kalachikov, James Russo, John J. Kasianowicz, Stefan Roever, George Church, Jingyue Ju
DNA sequencing by synthesis (SBS) offers a robust platform to decipher nucleic acid sequences. Recently, we developed a single molecule nanopore-based SBS strategy (NanoSBS) that accurately distinguishes four bases by electronically detecting and

National Institute of Standards and Technology measurement service of the optical properties of biomedical phantoms: Current status

March 24, 2016
Author(s)
Paul Lemaillet, Catherine C. Cooksey, Zachary H. Levine, Adam L. Pintar, Jeeseong Hwang, David W. Allen
The National Institute for Standards and Technology (NIST) has maintained scales of reflectance and transmittance over several decades. Those scales are primarily intended for the regular transmittance, mirrors, and solid surface scattering diffusers. The

Variability and bias assessment in breast ADC measurement across multiple systems

February 29, 2016
Author(s)
Kathryn E. Keenan, Sheye O. Aliu, Lisa J. Wilmes, David C. Newitt, Ella F. Jones, Wen Li, Michael A. Boss, Karl F. Stupic, Stephen E. Russek, Nola M. Hylton
Purpose: To assess the ability of a recent, anatomically designed breast phantom incorporating T 1 and diffusion elements to serve as a quality control device for quantitative comparison of apparent diffusion coefficient (ADC) measurements calculated from
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