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Bioscience

Proteomics

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Displaying 101 - 125 of 131

C3a receptor antagonism as a novel therapeutic target for chronic rhinosinusitis

June 15, 2018
Author(s)
Jennifer K. Mulligan, Tucker Williamson, Nicholas Reaves, William Carroll, Sarah Stephenson, Peng Gao, Richard R. Drake, Ben Neely, Rodney J. Schlosser, Carl Atkinson
Background: Innate immune factors, including the complement system, have been implicated in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP). Here we examine complement activity within the respiratory mucosa of CRSwNP patients, and a

The role of mass spectrometry in the characterization of biologic protein products

April 25, 2018
Author(s)
Deepali Rathore, John E. Schiel, Anneliese Faustino, Eric Pang, Michael Boyne, Sarah M. Rogstad
Introduction: Mass spectrometry (MS) is widely used in the characterization of biomolecules including peptide and protein therapeutics. These biotechnology products have seen rapid growth over the past few decades and continue to dominate the global

The NISTmAb Tryptic Peptide Spectral Library for Monoclonal Antibody Characterization

March 6, 2018
Author(s)
Qian Dong, Yuxue Liang, Xinjian Yan, Sanford Markey, Yuri Mirokhin, Dmitrii V. Tchekhovskoi, Tallat H. Bukhari, Stephen E. Stein
We describe the creation of a mass spectral library composed of all identifiable spectra derived from the tryptic digest of a therapeutic monoclonal antibody. The NISTmAb library is a unique reference peptide spectral library developed from a total of six

Assessment of extracellular vesicles purity using proteomic standards

September 26, 2017
Author(s)
Tingting Wang, Kyle Anderson, Illarion Turko
The increasing interest in extracellular vesicles (EVs) research is fueled by reports indicating their unique role in intercellular communication and potential connection to the development of common human diseases. The unique role assumes unique protein

The Hybrid Search: A Mass Spectral Library Search Method for Discovery of Modifications in Proteomics

April 3, 2017
Author(s)
Meghan C. Burke, Yuri A. Mirokhin, Dmitrii V. Tchekhovskoi, Sanford P. Markey, Stephen E. Stein, Jenny Heidbrink Thompson, Christopher Larkin
We present a mass spectral library based method to identify tandem mass spectra of peptides that contain unanticipated modifications and amino acid variants. We describe this as a ‘hybrid’ method since it combines matching both ion m/z and mass losses. The
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