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Bioscience

Biomaterials

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Displaying 776 - 800 of 3439

The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets

July 31, 2014
Author(s)
Silvia H. De Paoli Lacerda, Lukas Diduch, Tseday Tegegn, Martina Orecna, Michael Strader, Elena Karnaukhova, John Bonevich, Abdu Alayash, Karel Holada, Jan Simak
Carbon nanotubes (CNT) are one of the most promising nanomaterials for use in medicine. Applications of CNT in drug/gene delivery, diagnostics and tissue engineering, among other applications, require contact of CNT with blood. Therefore, evaluation of

Toxicity of carboxylated carbon nanotubes in endothelial cells is attenuated by stimulation of the autophagic flux associated with the release of nanomaterial in autophagic vesicles

July 1, 2014
Author(s)
Martina Orecna, Silvia De Paoli Lacerda, Olga Janouskova, Tseday Tegegn, Marcela Filapova, John E. Bonevich, Jan Simak
Here, we present a new method for the pharmacological modulation of the vascular toxicity of carbon nanotubes. We report that carboxylated multiwalled carbon nanotubes (MWCNTs) induce autophagosome accumulation in cultured human umbilical vein endothelial

Viscoelastic Characterization of Fusion Processing in Bimodal Polyethylene Blends

June 2, 2014
Author(s)
Aaron M. Forster, Wei-Lun Ho, Kar T. Tan, Donald L. Hunston
Polyethylene is an advantageous material for the construction of buried pipelines. It is corrosion resistant, seismic tolerant, and utilizes low cost installation methods. Pipe sections are often joined using thermal fusion processes. The strength of the

DNA-based Nanocomposite Bio-Coatings for Fire Retarding Polyurethane Foam

May 2, 2014
Author(s)
Yu-Chin Li, Yeon S. Kim, John R. Shields, Rick D. Davis
Layer-by-Layer (LbL) assembled multilayer thin films of deoxyribonucleic acid (DNA), chitosan (CHI), and montmorillonite (MMT), were studied in an effort to produce fully renewable, bio-based fire retardant coatings for flexible polyurethane foam. The PUF

Combinatorial Cassette for Screening of Osteogenesis by Transplanted Human Bone Marrow Stromal Cells

April 19, 2014
Author(s)
Subhadip Bodhak, Sheng Lin-Gibson, Carl G. Simon Jr., Luis Fernandez de Castro Diaz, Pamela G. Robey, Sergei A. Kuznetsov, Tina Kilts, Marian F. Young
The use of in vivo transplantation assays under defined experimental conditions has become a valuable standard for evaluating osteogenic potential of different stem cell populations and is the subject of ongoing pre-clinical reconstructive therapy research

Evaluation of the effect of donor variability on stem cell response to biomaterials

April 19, 2014
Author(s)
Stephen J. Florczyk, Bryan A. Baker, Sumona Sarkar, Jennifer H. McDaniel, Patrick S. Pine, Marc L. Salit, Carl G. Simon Jr.
Previous research from our group indicated that nanofiber scaffolds promoted osteogenic differentiation of human bone marrow stromal cells (hBMSC) and similar gene expression to osteogenic supplement (OS) induced osteogenic differentiation [1]. Biological

Measuring Organelle Shape in 3D in Stem Cells Cultured on Nanofiber Scaffolds

April 19, 2014
Author(s)
Carl G. Simon Jr., Peter Bajcsy, Wojtek J. Tutak, Jyotsnendu J. Giri
Previous work has demonstrated that culture of osteoprogenitor cells on nanofiber scaffolds can potentiate osteogenic differentiation [1-4]. Culture of cells in nanofiber scaffolds causes changes to cell morphology, suggesting that morphological changes

Comparison of the Properties of Cellulose Nanocrystals and Cellulose Nanofibrils Isolated From Bacteria, Tunicate, and Wood Processed Using Acid, Enzymatic, Mechanical, and Oxidative Methods

April 18, 2014
Author(s)
Iulia A. Sacui, Jeffrey W. Gilman, Ryan C. Nieuwendaal, Stephan J. Stranick, Henryk Szmacinski, Mehdi Jorfi, Christopher Weder, Johan Foster, Richard Olsson, Daniel Burnett
This work describes the study and characterization of native cellulose nanocrystals and nanofibrils (CNCs, CNFs), whose crystallinity, morphology, aspect ratio, and surface chemistry depend on the raw material source and hydrolysis conditions. Measurement

Measuring Stem Cell Dimensionality in Tissue Scaffolds

April 1, 2014
Author(s)
Carl G. Simon Jr., Sapun Parekh, Christopher K. Tison, Girish Kumar, Tanya M. Farooque, Charles H. Camp
Many 3D scaffold systems have evolved for tissue engineering, drug screening and in vitro tissue models. However, it is not clear which scaffolds provide a 3D cell niche and there is no clear way to measure cell niche dimensionality. Advances in 3D niche

Hydrodynamic Behavior of Carbon Nanotubes and Characterization of Length Distributions

February 28, 2014
Author(s)
Carlos A. Silvera Batista, Ming Zheng, Constantine Y. Khripin, Xiaomin X. Tu, Jeffrey Fagan
The sedimentation behavior of SWCNTs was studied through analytical ultracentrifugation. SWCNTs were dispersed with the aid of surfactants, doubly sorted by density and length to produce samples with invariant diameter distributions and aspect ratios that
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