Systematic Investigation of Porogen Size and Content on Scaffold Morphometric Parameters and Properties

Published

March 24, 2007

Author(s)

James A. Cooper, Forrest A. Landis, Marcus T. Cicerone, Sheng Lin-Gibson

Abstract

Abstract (2000 characters maximum - spell out acronyms the first time) A systematic investigation of the structures and properties of tissue engineering scaffolds prepared by salt leaching of a photopolymerized dimethacrylate was performed. Two series of scaffolds, 1) prepared with the same polymer-to-salt ratio but different salt sizes (ranging from average size of 100 um to 390 um), and 2) prepared with the same salt size but different polymer-to-salt ratios (ranging from salt mass of 70 % to 90 %), were examined to determine how these fabrication parameters affect the scaffold morphometric parameters and corresponding mechanical properties. Combined techniques of X-ray microcomputed tomography (uCT), mercury porosimetry, and gravimetric analysis were used to determine the scaffold structure, such as porosity, pore size and strut thickness and their distributions, and interconnectivity. Scaffolds with porosities ranging from 57 % to 92 % with interconnected structures could be fabricated using the current technique. The porosity and strut thickness were subsequently related to the mechanical response of the scaffolds, both of which contribute to compression modulus of the scaffold. The current study shows that the structure and properties of the scaffold could be tailored by the size and the amount of porogen used in the fabrication of the scaffold.

Citation

Journal of the American Chemical Society

Pub Type

Journals

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Keywords

mechanical properties, microstructure, photopolymerization, scaffold, tomography

Citation

Cooper, J. , Landis, F. , Cicerone, M. and Lin-Gibson, S. (2007), Systematic Investigation of Porogen Size and Content on Scaffold Morphometric Parameters and Properties, Journal of the American Chemical Society, [online], https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=852671 (Accessed April 26, 2024)