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Health Assessment Measurements Quality Assurance Program

Summary

The National Institute of Standards and Technology (NIST) established a Health Assessment Measurements Quality Assurance Program (HAMQAP) to support the measurement needs of the food, dietary supplement, and clinical communities. The HAMQAP concluded in 2021, and parts of the HAMQAP community will now be served through other programs such as ClinQAP, DSQAP, and FNSQAP.

Description

NIST established a Health Assessment Measurements Quality Assurance Program (HAMQAP), in part as a collaboration with the National Institutes of Health (NIH) Office of Dietary Supplements (ODS). Participants measured concentrations of nutritional and toxic elements, fat- and water-soluble vitamins, fatty acids, active and/or marker compounds, and contaminants in samples distributed by NIST.   Samples that represent human intake (e.g., foods, dietary supplements, tobacco) were paired with samples that represent human output (e.g., blood, serum, plasma, urine), and analytes were paired where possible to represent the full spectrum of health assessment.  Participant data was compiled at NIST and analyzed for accuracy, precision, and concordance within the community. Reports and certificates of completion were sent to participants.  The HAMQAP, which concluded in 2021, served a wide range of analytical testing communities, previously supported via historical QA programs, such as the Dietary Supplements Laboratory QAPMicronutrients Measurement QAPFatty Acids in Human Serum and Plasma QAP, and Vitamin D Metabolites QAP. New and revitalized programs at NIST will continue to support and serve these measurement communities: ClinQAP, DSQAP, and FNSQAP.

Contact

If you are interested in learning more about our current quality assurance programs or signing up to participate, please request an account at QAP HUB or contact us at QAPHUB [at] nist.gov ().

Major Accomplishments

Exercise 1

Study

Dietary Intake

Human Metabolism

Nutritional Elements

Iron in a multivitamin and cereal

Iron and transferrins in human serum

Toxic Elements

Arsenic in tobacco and kelp

Arsenic species in human urine

Water-Soluble Vitamins

Vitamin B12 in a multivitamin and cereal

Vitamin B12 in human serum

Fat-Soluble Vitamins

Vitamin D and 25(OH)D in bovine liver and cod liver oil

25OHD; 1,25(OH)2D; 24,25(OH)2D in human serum

Fatty Acids

10 fatty acids in a FAs solution, fish oil, and cod liver oil

10 fatty acids in a FAs solution and human plasma

Botanicals

Actein and  27-Deoxyactein in black cohosh matrices

None

Contaminants

Mycotoxins in corn materials

VOC Metabolites in human urine

Crossed out studies were offered but then cancelled due to low enrollment

Exercise 1 Final Report

Exercise 2

Study

Dietary Intake

Human Metabolism

Nutritional Elements

Iodine in a multivitamin and infant formula

Iodine, T3, T4, and TSH in human milk, urine, and serum

Toxic Elements

As, Cd, Pb, Hg, and Se in kudzu and eleuthero extracts

As, Cd, Pb, Hg, and Se in human blood

Water-Soluble Vitamins

Folates in meat homogenate and egg powder

Folates in human serum

Fat-Soluble Vitamins

Vitamins A & E in a multivitamin and infant formula

Vitamins A & E in human serum

Fatty Acids

Fatty acids in egg powder, spirulina, and palm oil powder

Fatty acids in human milk and serum

Natural Products

Eleutherosides inn eleuthero materials

CoQ10 in human serum

Contaminants

Acrylamide in coffee and peanut butter

None

Crossed out studies were offered but then cancelled due to low enrollment

Exercise 2 Final Report

Exercise 3

Study

Dietary Intake

Human Metabolism

Nutritional Elements

Iodine & selenium in table salt, cat food, and a protein drink

Iodine, selenium & thyroid hormones in human milk and serum

Toxic Elements

As, Cd, Pb, and Hg in black cohosh and hemp hearts

As, Cd, Pb, and Hg in human blood

Water-Soluble Vitamins

Folic acid & folates in a multivitamin and infant formula

Folates in human serum

Fat-Soluble Vitamins

Carotenoids in a multivitamin and saw palmetto extract

Carotenoids in human and animal serums

Botanicals

Isoflavones in soy and red clover materials

Equol in human urine

Natural Products

CoQ10 in supplements

CoQ10 in human and animal serums

Contaminants

Furans in coffee, baby food, and cereal

Furan metabolites in human urine

Inflammation Markers

None

Calprotectin and zonulin in human plasma

Crossed out studies were offered but then cancelled due to low enrollment

Exercise 3 Final Report

Exercise 4

Study

Dietary Intake

Human Metabolism

Nutritional Elements

Ca, Na, and K in a multivitamin and sauerkraut

Ca, Na, and K in human serum and animal blood

Toxic Elements

Cd & Pb in peanut butter and baking chocolate

Cd & Pb in animal blood

Water-Soluble Vitamins

Vitamin B12 in a multivitamin and infant formula

Vitamin B12 in human serum

Fat-Soluble Vitamins

Carotenoids in a multivitamin and saw palmetto extract

Vitamin K in human serum

Fatty Acids

Select Omega-3 and Omega-6 Fatty Acids in fish oils

Select Omega-3 and Omega-6 Fatty Acids in human serum

Botanicals

Phenolics and Naphthodianthrones in St. John’s Wort materials

None

Contaminants

Nitrate and nitrite in spinach and meat homogenate

Nitrate and nitrite in human urine

Crossed out studies were offered but then cancelled due to low enrollment

Exercise 4 Final Report

Exercise 5

Study

Dietary Intake

Human Metabolism

Nutritional Elements

Ca, Na, Fe, and K in rice and wheat flours

Ca, Na, Fe, and K in human serum

Toxic Elements

As species in shrimp materials

As species in human urine

Water-Soluble Vitamins

Vitamins B1, B2, B3, B5, and B6 in a multivitamin and infant formula

Homocysteine and methylmalonic acid in human serum

Fat-Soluble Vitamins

Vitamin D in a multivitamin and infant formula

Vitamin D metabolites in human serum

Fatty Acids

Select omega-3 and omega-6 fatty acids in salmon and fish oil

Select omega-3 and omega-6 fatty acids in red blood cells

Botanicals

Catechins and xanthines in green tea materials

None

Natural Products

Caffeine, theobromine, and theophylline in green tea and yerba mate

None

Contaminants

Chlorate and perchlorate in infant formulas

Chlorate and perchlorate in human urine

Proximates

Fat, protein, carbohydrates, moisture, and calories in almond and hazelnut flours

None

Crossed out studies were offered but then cancelled due to low enrollment

Exercise 5 Final Report

Exercise 6

Study

Dietary Intake

Human Metabolism

Nutritional Elements

Chloride, Iodine, Chromium, molybdenum, and selenium in a multivitamin and infant formula

Chloride, Iodine, Chromium, molybdenum, and selenium in human serum and animal plasma

Toxic Elements

As, Cd, Pb, and Hg in rice flour and green tea

As, Cd, Pb, and Hg in animal blood and plasma

Water-Soluble Vitamins

Biotin and vitamin C in a multivitamin and infant formula

Biotin and vitamin C in human serum

Fat-Soluble Vitamins

Vitamins A & E in a multivitamin and infant formula

Vitamins A & E in human serum

Fatty Acids

Select omega-3 and omega-6 fatty acids in anchovies, sardines, and fish oil

Select omega-3 and omega-6 fatty acids in red blood cells

Botanicals

Anthocyanidins in cranberry, blueberry, and bilberry materials

None

Natural Products

Caffeine, theobromine, and theophylline in protein supplements

Caffeine, theobromine, and theophylline in human urine

Contaminants I

Chlorate and perchlorate in infant formulas

Chlorate and perchlorate in human urine

Contaminants II

Glyphosate and AMPA in oats

Glyphosate and AMPA in human urine

Crossed out studies were offered but then cancelled due to low enrollment

Exercise 6 Final Report

Exercise 7

Study

Dietary Intake

Human Metabolism

Nutritional Elements

Ca, Mg, and Z in enhanced waters

Ca, Mg, and Z in enhanced waters in human and animal serums

Toxic Elements

As, Cd, Pb, and Hg in black cohosh and ashwagandha materials

As, Cd, Pb, and Hg in animal blood and plasma

Water-Soluble Vitamins

Vitamins B2 & B6 in a multivitamin and protein supplement

Vitamins B2 & B6 and homocysteine in human serum

Fat-Soluble Vitamins

Vitamin K in a multivitamin and kelp

Vitamin K in human serum

Botanicals

Gingerols in ginger containing materials

None

Natural Products

Caffeine, theobromine, and theophylline in protein supplements

None

Protein Source ID

Protein source (casein, pea, rice, soy, whey) in protein supplements

None

All studies were run, even with low enrollment in the human metabolism studies

Exercise 7 Final Report coming soon.

Created October 25, 2017, Updated February 25, 2022