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Micronutrients Measurement Quality Assurance Program

Summary

The Micronutrients Measurement Quality Assurance Program was coordinated by the Chemical Sciences Division and supported measurement technology for selected fat- and water-soluble vitamins and carotenoids in human serum. This program was initiated in 1984 by the National Cancer Institute Division of Cancer Prevention and Control to ensure the long-term reliability of the measurements made while studying the possible cancer chemoprevention roles of these compounds. This program provided participants with measurement comparability assessment through use of interlaboratory comparison studies, Standard Reference Materials and control materials, and methods development and validation. The MMQAP concluded in 2017, and parts of the MMQAP community will now be served through the HAMQAP.

Description

NIST Micronutrients Measurement Quality Assurance (QA) supported the long-term (months to years) reliability of selected fat- or water-soluble vitamin measurements in human serum and plasma. Results from the comparison studies helped participants to make accurate clinical and health-care decisions as well as to maintain and improve their measurement comparability.

Major Accomplishments

The Micronutrients Measurement QA Program at NIST administered over 90 interlaboratory comparison exercises for the measurement of selected fat- and water-soluble vitamins in human serum and plasma. The comparability of laboratory measurements for target analytes improved substantially over time through the development and promulgation of robust measurement technologies, identification and production of suitable reference materials, isolation and identification of measurement system biases, and support and encouragement of long-term within-laboratory measurement quality control efforts. The average estimated coefficient of variation for retinol and α-tocopherol has been approximately 5% and about 10% for β-carotene since 2000.

micronuts qap

Study Reports

Reports for intercomparisons from 1988 onward are available:

1986
NIST Interagency/Internal Report (NISTIR) 7880-38

1987
NIST Interagency/Internal Report (NISTIR) 7880-37

1988
NIST Interagency/Internal Report (NISTIR) 7880-36

1989
NIST Interagency/Internal Report (NISTIR) 7880-35

1990
NIST Interagency/Internal Report (NISTIR) 7880-34

1991
NIST Interagency/Internal Report (NISTIR) 7880-33

1992
NIST Interagency/Internal Report (NISTIR) 7880-32

1993
NIST Interagency/Internal Report (NISTIR) 7880-31

1994
NIST Interagency/Internal Report (NISTIR) 7880-30

1995
NIST Interagency/Internal Report (NISTIR) 7880-29

1996
NIST Interagency/Internal Report (NISTIR) 7880-28

1997
NIST Interagency/Internal Report (NISTIR) 7880-27
NIST Interagency/Internal Report (NISTIR) 7880-40

1998
NIST Interagency/Internal Report (NISTIR) 7880-26

1999
NIST Interagency/Internal Report (NISTIR) 7880-25

2000
NIST Interagency/Internal Report (NISTIR) 7880-24

2001
NIST Interagency/Internal Report (NISTIR) 7880-23
NIST Interagency/Internal Report (NISTIR) 7880-22

2002
NIST Interagency/Internal Report (NISTIR) 7880-21
NIST Interagency/Internal Report (NISTIR) 7880-20

2003
NIST Interagency/Internal Report (NISTIR) 7880-19
NIST Interagency/Internal Report (NISTIR) 7880-18

2004
NIST Interagency/Internal Report (NISTIR) 7880-17
NIST Interagency/Internal Report (NISTIR) 7880-16

2005
NIST Interagency/Internal Report (NISTIR) 7880-15
NIST Interagency/Internal Report (NISTIR) 7880-14

2006
NIST Interagency/Internal Report (NISTIR) 7880-13
NIST Interagency/Internal Report (NISTIR) 7880-12

2007
NIST Interagency/Internal Report (NISTIR) 7880-11
NIST Interagency/Internal Report (NISTIR) 7880-10

2008
NIST Interagency/Internal Report (NISTIR) 7880-9
NIST Interagency/Internal Report (NISTIR) 7880-8

2009
NIST Interagency/Internal Report (NISTIR) 7880-7
NIST Interagency/Internal Report (NISTIR) 7880-6

2010
NIST Interagency/Internal Report (NISTIR) 7880-5
NIST Interagency/Internal Report (NISTIR) 7880-4

2011
NIST Interagency/Internal Report (NISTIR) 7880-3
NIST Interagency/Internal Report (NISTIR) 7880-2

2012
NIST Interagency/Internal Report (NISTIR) 7880
NIST Interagency/Internal Report (NISTIR) 7880-1

2013
NIST Interagency/Internal Report (NISTIR) 7880-41
NIST Interagency/Internal Report (NISTIR) 7880-42

2014
NIST Interagency/Internal Report (NISTIR) 7880-43
NIST Interagency/Internal Report (NISTIR) 7880-44

2015
NIST Interagency/Internal Report (NISTIR) 7880-45
NIST Interagency/Internal Report (NISTIR) 7880-46

2016
NIST Interagency/Internal Report (NISTIR) 7880-40
NIST Interagency/Internal Report (NISTIR) 7880-47

2017
NIST Interagency/Internal Report (NISTIR) 7880-48

Related Standard Reference Materials

SRM 968f Fat-Soluble Vitamins in Frozen Human Serum

SRM 968f Fat-Soluble Vitamins in Frozen Human Serum is intended for use in validating methods for determining fat-soluble vitamins in human serum and plasma and qualifying control materials produced in-house and analyzed using those methods.  This SRM may be purchased from the Office of Reference Materials at NIST (301-975-2200; fax: 301-948-3730; or e-mail: srminfo [at] nist.gov link sends email).


ASSOCIATED PUBLICATIONS

If you or your institution subscribe to the journal cited below, clicking on the link should take you to a page from which you can access the reference.

Serum-based samples with assigned values for target analytes (e.g., retinol, tocopherols, and β-carotene) and performance-evaluation standards were distributed by NIST to participants for analysis. NIST staff provided participants with technical feedback concerning their measurement performance and suggestions for methods development and refinement. A certificate of participation in the QA program was issued at the end of each calendar year.

Created December 31, 2008, Updated September 7, 2018