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Bioprocess Measurements Group

The Bioprocess Measurements Group develops measurement methods and standards that support a variety of application areas, particularly those relevant to biological industrial processes.

Areas of current active interest include:

  • Standards and new methods for counting and characterizing protein particles in biotherapeutics
  • Novel sensors for monitoring health and industrial manufacture of biological products
  • Innovative device platforms and signal processing methods
  • Affinity-based assays of the glycosylation (sugar decoration) patterns in biotherapeutic proteins
  • Protein conformation studies, in solution and adsorbed to surfaces.

We combine expertise in instrumentation science, nanomaterials, and chemical and physical characterization of surfaces, sensor materials, and biological molecules.

News and Updates

Projects and Programs

Nanocalorimetry

Nanocalorimetry using micromachined devices has the capability to provide quantitative data to support the development of advanced metal silicide metallizations

HDX-MS for Biopharmaceutical Analysis

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins,

Publications

Interlaboratory Comparison of Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) MMeasurements of the Fab fragment of NISTmAb

Author(s)
Jeffrey W. Hudgens, Ioannis L. Karageorgos, Elyssia S. Gallagher, Kyle W. Anderson, James J. Filliben, Richard Y. Huang, Guodong Chen, Michael J. Chalmers, Benjamin T. Walters, Jennifer Zhang, John Venable, Caitlin Steckler, In Hee Park, Ansgar Brock, Xiaojun Lu, Ratnesh Pandey, Arun Chandramohan, Ganesh Srinivasan Anand, Sasidhar N. Nirudodhi, Justin Sperry, Jason C. Rouse, James A. Carroll, Kasper D. Rand, Ulrike Leurs, David D. Weis, Mohammed A. Al-Naqshabandi, Tyler S. Hageman, Patrick Wintrode, John D. Lambris, Sarah Urata, George M. Bou-Assaf, Alfonso Espada
Hydrogen-deuterium exchange mass spectrometry (HDX-MS) is an established, powerful tool for investigating protein-ligand interactions, protein folding, and