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Bioprocess Measurements Group

The Bioprocess Measurements Group develops measurement methods and standards that support a variety of application areas, particularly those relevant to biological industrial processes.

Areas of current active interest include:

  • Standards and new methods for counting and characterizing protein particles in biotherapeutics
  • Novel sensors for monitoring health and industrial manufacture of biological products
  • Innovative device platforms and signal processing methods
  • Affinity-based assays of the glycosylation (sugar decoration) patterns in biotherapeutic proteins
  • Protein conformation studies, in solution and adsorbed to surfaces.

We combine expertise in instrumentation science, nanomaterials, and chemical and physical characterization of surfaces, sensor materials, and biological molecules.

News and Updates

Projects and Programs

Biomanufacturing Initiative

Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

Nanocalorimetry

Nanocalorimetry using micromachined devices has the capability to provide quantitative data to support the development of advanced metal silicide metallizations

Publications

Conformational gating, dynamics and allostery in human monoacylglycerol lipase

Author(s)
Sergiy Tyukhtenko, Girija Rajarshi, Ioannis L. Karageorgos, Nikolai Zvonok, Kiran Vemuri, Jeffrey W. Hudgens, Xiaoyu Ma, Mahmoud L. Nasr, Alexandros Makriyannis, Kyle W. Anderson, Jason J. Guo, Gerhard Wagner
Inhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active

Phase-Appropriate Application of Analytical Methods to Monitor Subvisible Particles Across the Biotherapeutic Drug Product Life Cycle

Author(s)
Roman Mathaes, Linda Narhi, Andrea Hawe, Anja Matter, Karoline Bechtold-Peters, Sophia Kenrick, Sambit Kar, Olga Laskina, John Carpenter, Richard E. Cavicchi, Ellen Koepf, Neil Lewis, Rukman De Sliva, Dean C. Ripple
The phase-appropriate application of analytical methods to characterize, monitor, and control particles is an important aspect of the development of safe and

Awards