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Bioprocess Measurements Group

The Bioprocess Measurements Group develops measurement methods and standards that support a variety of application areas, particularly those relevant to biological industrial processes.

Areas of current active interest include:

  • Standards and new methods for counting and characterizing protein particles in biotherapeutics
  • Novel sensors for monitoring health and industrial manufacture of biological products
  • Innovative device platforms and signal processing methods
  • Affinity-based assays of the glycosylation (sugar decoration) patterns in biotherapeutic proteins
  • Protein conformation studies, in solution and adsorbed to surfaces.

We combine expertise in instrumentation science, nanomaterials, and chemical and physical characterization of surfaces, sensor materials, and biological molecules.

News and Updates

Projects and Programs

Biomanufacturing Initiative

Ongoing
Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

HDX-MS for Biopharmaceutical Analysis

Ongoing
This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

Nanocalorimetry

Ongoing
Nanocalorimetry using micromachined devices has the capability to provide quantitative data to support the development of advanced metal silicide metallizations

Publications

Copper‑binding anticancer peptides fromthepiscidin family: anexpanded mechanism thatencompasses physical andchemical bilayer disruption

Author(s)
Fatih Comert, Frank Heinrich, Ananda Chowdhury, Mason Schoeneck, Caitlin Darling, Kyle Anderson, M. Daben J. Libardo, Alfredo Angeles‑Boza, Vitalii I. Silin, Myriam Cotten, Mihaela Mihailescu
In the search for novel broad‑spectrum therapeutics to fight chronic infections, inflammation, and cancer, host defense peptides (HDPs) have garnered increasing

Awards