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Bioprocess Measurements Group

The Bioprocess Measurements Group develops measurement methods and standards that support a variety of application areas, particularly those relevant to biological industrial processes.

Areas of current active interest include:

  • Standards and new methods for counting and characterizing protein particles in biotherapeutics
  • Novel sensors for monitoring health and industrial manufacture of biological products
  • Innovative device platforms and signal processing methods
  • Affinity-based assays of the glycosylation (sugar decoration) patterns in biotherapeutic proteins
  • Protein conformation studies, in solution and adsorbed to surfaces.

We combine expertise in instrumentation science, nanomaterials, and chemical and physical characterization of surfaces, sensor materials, and biological molecules.

News and Updates

Projects and Programs

HDX-MS for Biopharmaceutical Analysis

This project applies hydrogen/deuterium exchange mass spectrometry (HDX-MS) for determining the dynamical structure of therapeutic antibodies, glycoproteins

Surrogate protein particle standards

Protein-based drugs can degrade by aggregation into micrometer-sized particles. Such particles, although only a minute fraction of the total protein, sometimes

Biomanufacturing Initiative

Protein drugs are the top selling pharmaceuticals worldwide, a hundred billion dollar industry, but also the fastest growing category of health care costs. The

Publications

Copper‑binding anticancer peptides fromthepiscidin family: anexpanded mechanism thatencompasses physical andchemical bilayer disruption

Author(s)
Fatih Comert, Frank Heinrich, Ananda Chowdhury, Mason Schoeneck, Caitlin Darling, Kyle Anderson, M. Daben J. Libardo, Alfredo Angeles‑Boza, Vitalii I. Silin, Myriam Cotten, Mihaela Mihailescu
In the search for novel broad‑spectrum therapeutics to fight chronic infections, inflammation, and cancer, host defense peptides (HDPs) have garnered increasing

Conformational gating, dynamics and allostery in human monoacylglycerol lipase

Author(s)
Sergiy Tyukhtenko, Girija Rajarshi, Ioannis Karageorgos, Nikolai Zvonok, Kiran Vemuri, Jeffrey W. Hudgens, Xiaoyu Ma, Mahmoud L. Nasr, Alexandros Makriyannis, Kyle Anderson, Jason J. Guo, Gerhard Wagner
Inhibition of human Monoacylglycerol Lipase (hMGL) offers a novel approach for treating neurological diseases. The design of inhibitors, targeting active

Awards