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Vibrational spectroscopies are pivotal in analytical methods and biomedical diagnostics owing to their singular ability to provide molecular specificity. Yet, they are intrinsically limited by weak light-matter interactions and their vulnerability to intensity fluctuations and spectral interference. Herein, we propose a novel sensing strategy by leveraging hybrid light-matter states under vibrational strong coupling between molecular vibrations and an optical cavity mode. These quantum vibro-polaritonic states exhibit characteristic vacuum Rabi splitting, which not only enables manipulation of molecular vibrations but also provides a new optical transducer. The feasibility of this strategy is established by combining theoretical analysis and numerical simulations. Further, through fabrication of a microfluidic infrared flow cell, definitive experimental validation of quantum vibro-polaritonic sensing is achieved. We believe this study represents a significant advancement in harnessing hybrid light-matter states for molecular sensing and offers exciting potential to impact applications in areas which include chemical sensing, environmental monitoring, biomedical diagnostics, and bioprocess monitoring.
Zheng, P.
, Semancik, S.
and Barman, I.
(2025),
Quantum Vibro-Polaritonic Sensing, Nano Letters, [online], https://doi.org/10.1126/sciadv.ady7670, https://tsapps.nist.gov/publication/get_pdf.cfm?pub_id=959869
(Accessed October 1, 2025)