Projects/Programs

Displaying 1 - 23 of 23

Photograph of a labeled amber bottle containing SRM 2429.

Activated Carbon and FGD Gypsum Standard Reference Materials

Completed

The role of mercury in the environment is now receiving close scrutiny because ultimately it can bioaccumulate as alkyl mercury in seafood with subsequent risk to human health through trophic transfer. Many industrial sources of mercury have been effectively reduced in recent years, but atmospheric...

Cell Counting for Cell Therapies

Ongoing

Recent Publications and Resources for Cell Counting and Related Measurements Tools NOW AVAILABLE : COMET (Counting Method Evaluation Tool) , A Shiny Application that executes the statistical analysis and reporting outlined in ISO 20391-2:2019 https://cell-counting.shinyapps.io/COMET/ Standards ISO...

Clinical Measurements Quality Assurance Program

Ongoing

The National Institute of Standards and Technology (NIST) established the Clinical Measurements Quality Assurance Program (ClinQAP) to support the measurement needs of the clinical community. Participants measure concentrations of marker compounds, contaminants, metabolites in clinical samples (e.g...

Photograph of several clinical Standard Reference Materials showing labeled boxes, bottles, vials, ampoules and printed certificates.

Development of Reference Methods and Reference Materials for Clinical Diagnostic Markers

Ongoing

Reference measurement procedures and standard reference materials help ensure accuracy and comparability of routine clinical assays. In addition, this work allows U.S. clinical diagnostic manufacturers to comply with the European Union directive regarding in-vitro diagnostic medical devices (IVD MD)...

Development of Serum-Based SRMs to Assess Nutritional Status

Ongoing

Vitamin deficiencies are generally considered rare in the U.S., but a growing body of evidence suggests that certain deficiencies may be more prevalent than originally thought. For example, it has been estimated that 10 % to 15 % of adults over the age of sixty are affected by vitamin B 12...

Dietary Supplement Laboratory Quality Assurance Program (DSQAP)

Ongoing

Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing an annual expenditure of more than $20 billion. Regulations, driven by reported cases of inaccurate labeling, adulteration, contamination (with pesticides, heavy metals, or...

Dietary Supplement Laboratory Quality Assurance Program (DSQAP) Consortium

Ongoing

The objective of the DSQAP Consortium is to develop and evaluate measurement methods and standards to support quality and safety for the dietary supplement testing community. Approximately 75% of the U.S. population takes dietary supplements, including vitamins and mineral supplements, representing...

Photograph of SRM 2378 Fatty Acids in Human Serum showing three vials labeled Serum 1, Serum 2, and Serum 3.

Fatty Acids in Human Serum and Plasma Quality Assurance Program (FAQAP)

Completed

Interlaboratory comparison studies of the FAQAP focused on the measurement of 24 fatty acids in selected serum and plasma matrices. Frozen or freeze-dried serum or plasma samples were sent to laboratories for analysis together with control materials. Results were returned to NIST for data evaluation...

Food Nutrition and Safety Measurements Quality Assurance Program (FNSQAP)

Ongoing

As part of a revamp of QAPs in 2021, NIST established the FNSQAP to support the NIST Food Safety Program and Measurements and Standards to Support Nutrition Labeling. Participants measure nutrient components (e.g., minerals, vitamins, fatty acids, dietary fiber) and contaminants (e.g., toxic...

Gene Delivery Systems

Ongoing

Viral Vectors Viral vectors are a critical tool for delivering DNA or RNA into patient’s cells. Common viral vectors for gene therapy include adenovirus, lentivirus, and adeno associated virus. Administration of viral vectors can occur in vivo or ex vivo , such as for adeno associated virus or...

Health Assessment Measurements Quality Assurance Program (HAMQAP)

Completed

Participants in the HAMQAP measured concentrations of nutritional and toxic elements, fat- and water-soluble vitamins, fatty acids, active and/or marker compounds, and contaminants in samples distributed by NIST.   Samples that represent human intake (e.g., foods, dietary supplements, tobacco) were...

Human Gut Microbiome Reference Material

Ongoing

The most common measurements currently being used to describe these complex microbial communities are: NGS-based metagenomics Mass spectrometry-based metabolomics In either case, no fit-for-purpose standards exist that enable researchers to compare results generated across different laboratories and...

Measurements and Standards for Botanical Dietary Supplements

Ongoing

Many consumers believe that botanical dietary supplements will improve their health and that these "natural" remedies are both effective and free from the side effects that may occur with other medications. There are occasional reports of inaccurate labeling, adulteration, contamination (with...

Measurements and Standards to Support Nutrition Labeling

Ongoing

Well-characterized certified reference materials are needed by laboratories in the food testing and nutrition communities to facilitate compliance with labeling laws and improve the accuracy of information provided on product labels so that consumers can make good choices. As a result of the...

Wordcloud figure with about 25 words including NIST, metabolomics, quality assurance, and measurements.

Metabolomics Quality Assurance and Quality Control Materials (MetQual) Program

Ongoing

Metabolomics, a rapidly growing field of systems biology, is expanding beyond human health and precision medicine to encompass areas such as food science, biomanufacturing, and forensic investigation. Analytical techniques include both targeted identification and quantification of metabolites and...

Micronutrients Measurement Quality Assurance Program (MMQAP)

Completed

The MMQAP supported the long-term (months to years) reliability of selected fat- or water-soluble vitamin measurements in human serum and plasma. Results from the comparison studies helped participants to make accurate clinical and health-care decisions as well as to maintain and improve their...

Montage of photographs depicting eggs, almonds, grain, milk, strawberries, fish, peanuts, and soybeans.

NIST Food Protein Allergen Program

Ongoing

Food allergen management is an increasingly important economic and public health concern; therefore, accurate and reliable allergen measurements are a crucial component of the management pathway. Traditional methods for food allergen detection are based on immunoassay techniques and are linked to a...

NIST/NOAA Intercomparison Program for Organic and Inorganic Contaminants in Marine Mammal Tissues

Completed

NIST manages the quality assurance of sampling and analysis of marine mammal tissues for persistent organic pollutants and trace elements. This process includes periodically coordinating interlaboratory comparison exercises for analytes relevant to NOAA's marine mammal monitoring efforts. The...

NIST Tools for Cannabis Laboratory Quality Assurance

Ongoing

Since the 1970s, cannabis (marijuana and hemp) and its constituent, Δ 9-tetrahydrocannabinol or THC, have been classified as Schedule I controlled substances. Seized evidence is tested by forensic laboratories, which verify the identity of the plant through macro- and microscopic evaluation and the...

NIST26: Updates to the NIST Electron Ionization and Tandem Mass Spectral Libraries

Ongoing

NIST/EPA/NIH EI-MS Library, 2026 release 431,277 electron ionization (EI) spectra 382,180 compounds, 49,097 replicate spectra 35,080 more compounds than the 2023 release 527,993 retention index (RI) values 216,093 compounds measured under a variety of conditions 188,198 compounds with both RI & MS...

Saccharomyces cerevisiae (RM 8230): A NIST Reference Material Supporting Research and Quality Assurance in Multiple Microbial Fields

Ongoing

Quantification of total and viable microbial cells is essential across a wide range of scientific and industrial applications—from evaluating DNA extraction efficiency in support of microbial DNA-based techniques to validating antimicrobial treatments and benchmarking technologies for microbial...

US TAG for ISO/TC 334: Reference Materials

Ongoing

Get involved: Interested US Stakeholders may participate in the US TAG at no cost. Membership provides access to all ISO/TC 334 and US TAG documents, including standards under development. Please click here to join or renew your membership. Contribute to standards development : Please click here to...

Vitamin D Metabolites Quality Assurance Program (VitDQAP)

Completed

Interlaboratory comparison studies of the VitDQAP supported the reliability of vitamin D measurements, including determination of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, and 3- epi-25-hydroxyvitamin D3 in human serum and plasma. Results from the comparison studies helped participants to make...

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