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Projects/Programs

Keyword

Organizational Unit

Our group examines best practices for the storage and monitoring of vaccines in partnership with the Centers for Disease Control and Prevention’s (CDC) Vaccine Supply and Assurance Branch. Vaccines are highly temperature sensitive, and inappropriate storage conditions can render them ineffective...

Renewal of NIST Benchmark SRMs for Accurate Determinations of Trace Elements in Serum and Liver Tissues

Completed

NIST has maintained two benchmark materials, a fresh-frozen animal serum SRM and a freeze-dried powdered bovine liver tissue, SRM 1598 Bovine Serum and SRM 1577b Bovine Liver, respectively. The renewals of these materials had to address the challenges of very low levels of trace elements typically...

RMAT Laboratory Programs

Ongoing

Examples of Current Activities: Cell Counting and viability are key measurements critical for decision making from R&D to manufacturing. We recently developed an approach for evaluating the quality of cell counting measurements through experimental design and statistical analysis that does not...

Saccharomyces cerevisiae (RM 8230): A NIST Reference Material Supporting Research and Quality Assurance in Multiple Microbial Fields

Ongoing

Quantification of total and viable microbial cells is essential across a wide range of scientific and industrial applications—from evaluating DNA extraction efficiency in support of microbial DNA-based techniques to validating antimicrobial treatments and benchmarking technologies for microbial...

Smart Grid Interoperability Testbed Facility

Ongoing

Objective - To develop and progress an advanced multi-mode interacting measurement testbed that leverage cross-OU expertise to facilitate implementation, validation, and full characterization of smart grid interoperability standards and smart grid performance, with a particular emphasis on DER...

Smart Grid Testing and Certification

Completed

Objective: To accelerate the development of new test programs and improve existing test programs for smart grid interoperability and security by utilizing the ANSI/NEMA Interoperability Process Reference Manual (IPRM) testing and certification framework, and demonstrating benefits of testing and...

Solid-state lighting metrology

Ongoing

Light Emitting Diodes (LEDs) are increasingly being introduced into lighting market, and solid state lighting (SSL) is becoming a reality. But, this new technology still faces many challenges. Lighting consumes a huge amount of energy, currently 22% of all electricity consumed in the U.S. White LED...

Speaker and Language Recognition

Ongoing

Current Speaker and Language Recognition technology activities: Speaker Recognition Evaluation series: (1996-) A biennial NIST evaluation of fully automated text-independent speaker recognition technology. View the 2012 NIST SRE report. Human Assisted Speaker Recognition Evaluation series: (2010- )...

Speech Analytics

Ongoing

Current speech analytics work: OpenSAT is a new speech analytic evaluation series designed to include developers from multiple speech analytic technologies where common datasets are used in NIST evaluations. The goal is to bring together developers focused on different speech analytic tasks to...

Standard Platinum Resistance Thermometer Calibration Laboratory (SPRTCL)

Ongoing

The SPRTCL provides an extensive list of calibration services that cover the whole temperature range for which long-stem SPRTs, including high-temperature SPRTs, are the ITS-90 interpolation artifacts. This range spans from the triple point of argon (-189.3442 °C) to the freezing point of silver...

Photograph of a packaged unit of SRM 2700 Hexavalent chromium in Contaminated Soil (low Level)

Standard Reference Materials for Hexavalent Chromium in Contaminated Soil

Completed

During the last century, chromate and dichromate chemical production facilities processed considerable amounts of chromite ore for industrial manufacturing purposes. The waste material from these operations called chromite ore processing residue (COPR) was disposed of in waste sites across the...

Standard Solution SRMs Provide Traceability for Millions of Measurements

Ongoing

Literally millions of measurements of elemental composition are performed each year worldwide. The vast majority of these measurements depend upon reference materials for establishing traceability of results to the SI. Leveraged through commercial CRM producers, the NIST SRM 3100 series provides an...

Standards

Ongoing

Standards for Optical Based Standoff Detection NIST is researching methods for creating explosive threat materials standards relevant to optical detection technologies (e.g. that result in samples with particle morphologies similar to those found in explosive threat devices). This includes both...

DNA Plasmid containing 13 PCR targets for water quality testing

Standards for Assessing the Safety of Recreational Waters from Fecal Contamination

Completed

Over 286 million Americans get their tap water from a community water system. To assure the water safety, bacterial testing must be performed regularly. Major sources of contaminants include human derived sources, such as sewage leaks or combined sewer overflows; and agricultural sources, such as...

Standards Development to Ensure Reliable Breath Analysis in the Field

Ongoing

Numerous volatile organic compounds (VOCs) have been identified in human breath. These compounds can be produced by the body or by organisms in the body (e.g., bacteria or viruses) and provide a non-invasive window into human health. Inexpensive point-of-care devices are being developed to diagnose...

Standards for Metagenomics

Ongoing

Metagenomics is a powerful technology combining high-throughput (a.k.a. “next-generation”) sequencing with advanced bioinformatics to identify and quantify mixtures of organisms in a sample. Metagenomics workflows consist of 4 main steps: Sample collection: location, amount, storage, etc. Extraction...

Standards to Support Biological Detection in the Field

Ongoing

NIST is working in partnership with the Department of Homeland Security Science and Technology Directorate (DHS S&T) to develop methods, guidance, standards, and reference materials to support and improve our Nation's ability to detect and respond to suspected biothreat incidents. Specific...

First responders collecting samples of the yeast surrogate material during a field exercise. (Credit: NIST)

Standards to Support Biothreat Detection

Ongoing

Since 9/11 and the subsequent anthrax attacks in 2001, suspicious white powder incidents continue to occur within the US, often requiring Federal law enforcement response. Suspect samples are sent to public health laboratories for confirmatory evaluation, which can take hours to weeks to receive...

Structural Databases

Completed

Some of the current projects are a) http://xpdb.nist.gov/hivsdb/hivsdb.html HIVSDB b) http://bioinfo.nist.gov/SemanticWeb_pr2d/chemblast.do HIVSDB Chem-BLAST c) http://bioinfo.nist.gov/biofuels/ A resource for Biofuels d) http://xpdb.nist.gov/pdb/chemblast.html A ligand gateway for the Protein Data...

Study of Microheterogeneity in Solid Reference Materials

Ongoing

Presently there are a variety of analytical techniques that are served by few or no reference materials due to the small sample sizes they require. NIST currently certifies solid reference materials at or above the 100 mg mass level in most cases with no mention of the effect of using smaller sample...

Supporting Scientific Reviewing of Thermophysical and Thermochemical Research Publications (IUPAC 2023-008-1-024)

Ongoing

The checklists will include a common part covering identification of the studied compounds, properties, and methods, as well as specific parts for certain types of objects and measurements. Development of a web interface to select relevant lists and collect observations is planned. The checklists...

Surrogate Materials to Support Training in Biological Sampling and Detection in the Field

Ongoing

Nationwide, first responders regularly encounter suspicious materials that might be biological threat agents. Routine training and process evaluations help ensure workflows, operators, and technologies are working together properly within the concept of operations. Biological test materials have the...

Surrogate protein particle standards

Ongoing

Intended Impact This work will enable industry to obtain accurate, reproducible counts of protein particles, and to differentiate protein particles from other particle types, resulting in greater drug efficacy and safety. Objectives Create a polydisperse suspension of polymer particles that mimic...

Synthetic Biology

Ongoing

New measurement methods and tools are required for biology to emerge fully as an enabling, practical platform for engineering. The Cellular Engineering Group works to provide a foundation of measurement assurance to support the control and rational design of biological function. Through state of the...

Research Grade Testing Material (RGTM 10212), Synthetic Fecal Metabolite Calibrant (Credit: NIST)

Synthetic Fecal Metabolite Calibrant Solution (RGTM 10212)

Ongoing

Metabolomics is an exciting and dynamic field in life sciences that harnesses cutting-edge technologies to identify and characterize small molecules, or metabolites, within cells, tissues, or organisms, collectively known as the metabolome. The wealth of evidence in the literature underscores the...

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