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Standards

Projects/Programs

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Organizational Unit

Standards for Assessing the Safety of Recreational Waters from Fecal Contamination

Completed

Over 286 million Americans get their tap water from a community water system. To assure the water safety, bacterial testing must be performed regularly. Major sources of contaminants include human derived sources, such as sewage leaks or combined sewer overflows; and agricultural sources, such as

Standards Development to Ensure Reliable Breath Analysis in the Field

Ongoing

Numerous volatile organic compounds (VOCs) have been identified in human breath. These compounds can be produced by the body or by organisms in the body (e.g., bacteria or viruses) and provide a non-invasive window into human health. Inexpensive point-of-care devices are being developed to diagnose

Standards for Metagenomics

Ongoing

Metagenomics is a powerful technology combining high-throughput (a.k.a. “next-generation”) sequencing with advanced bioinformatics to identify and quantify mixtures of organisms in a sample. Metagenomics workflows consist of 4 main steps: Sample collection: location, amount, storage, etc. Extraction

Standards to Support Biological Detection in the Field

Ongoing

NIST is working in partnership with the Department of Homeland Security Science and Technology Directorate (DHS S&T) to develop methods, guidance, standards, and reference materials to support and improve our Nation's ability to detect and respond to suspected biothreat incidents. Specific

First responders collecting samples of the yeast surrogate material during a field exercise. (Credit: NIST)

Standards to Support Biothreat Detection

Ongoing

Since 9/11 and the subsequent anthrax attacks in 2001, suspicious white powder incidents continue to occur within the US, often requiring Federal law enforcement response. Suspect samples are sent to public health laboratories for confirmatory evaluation, which can take hours to weeks to receive

Structural Databases

Completed

Some of the current projects are a) http://xpdb.nist.gov/hivsdb/hivsdb.html HIVSDB b) http://bioinfo.nist.gov/SemanticWeb_pr2d/chemblast.do HIVSDB Chem-BLAST c) http://bioinfo.nist.gov/biofuels/ A resource for Biofuels d) http://xpdb.nist.gov/pdb/chemblast.html A ligand gateway for the Protein Data

Study of Microheterogeneity in Solid Reference Materials

Ongoing

Presently there are a variety of analytical techniques that are served by few or no reference materials due to the small sample sizes they require. NIST currently certifies solid reference materials at or above the 100 mg mass level in most cases with no mention of the effect of using smaller sample

Supporting Scientific Reviewing of Thermophysical and Thermochemical Research Publications (IUPAC 2023-008-1-024)

Ongoing

The checklists will include a common part covering identification of the studied compounds, properties, and methods, as well as specific parts for certain types of objects and measurements. Development of a web interface to select relevant lists and collect observations is planned. The checklists

Surrogate Materials to Support Training in Biological Sampling and Detection in the Field

Ongoing

Nationwide, first responders regularly encounter suspicious materials that might be biological threat agents. Routine training and process evaluations help ensure workflows, operators, and technologies are working together properly within the concept of operations. Biological test materials have the

Surrogate protein particle standards

Ongoing

Intended Impact This work will enable industry to obtain accurate, reproducible counts of protein particles, and to differentiate protein particles from other particle types, resulting in greater drug efficacy and safety. Objectives Create a polydisperse suspension of polymer particles that mimic

Synthetic Biology

Ongoing

New measurement methods and tools are required for biology to emerge fully as an enabling, practical platform for engineering. The Cellular Engineering Group works to provide a foundation of measurement assurance to support the control and rational design of biological function. Through state of the

Research Grade Testing Material (RGTM 10212), Synthetic Fecal Metabolite Calibrant (Credit: NIST)

Synthetic Fecal Metabolite Calibrant Solution (RGTM 10212)

Ongoing

Metabolomics is an exciting and dynamic field in life sciences that harnesses cutting-edge technologies to identify and characterize small molecules, or metabolites, within cells, tissues, or organisms, collectively known as the metabolome. The wealth of evidence in the literature underscores the

US TAG for ISO/TC 334: Reference Materials

Ongoing

Get involved: Interested US Stakeholders may participate in the US TAG at no cost. Membership provides access to all ISO/TC 334 and US TAG documents, including standards under development. Please click here to join or renew your membership. Contribute to standards development : Please click here to

U.S. TAG for ISO/TC276: Biotechnology

Ongoing

Get involved: Interested U.S. Stakeholders may participate in the US TAG at no cost. Membership provides access to all ISO/TC 276 and US TAG documents, including standards under development. Please click here to join. Contribute to standards development: Please click here to review, submit comment

Time Measurement and Analysis Service (TMAS)

Ongoing

The TMAS meets the requirements of any facility or organization that needs to maintain a high accuracy time standard. TMAS customers include calibration and metrology laboratories, telecommunication providers, instrumentation manufacturers, military installations, defense contractors, government

Training for Screeners and Lab Staff

Ongoing

Advances in primary screening technologies (x-ray, CT, AIT) have allowed the detection and discrimination of bulk quantities of potentially dangerous compounds on people or in bags. However, a secondary screening method - typically based on trace detection - is still required for correct

Transient Flow Facility

Completed

Impact Provide metrological tools and standards supporting the fair trade of hydrogen gas as a vehicle fuel of the future. Objectives Design, construct, and utilize a facility that mimics retail hydrogen fueling station conditions to quantify uncertainties of flow measurement standards and

SRM 3452 certified Seebeck coefficient data

Transport Property Measurements for Semiconductors and Energy Materials

Ongoing

The properties of materials and interfaces that govern reliability, performance, and thermal transport in advanced microelectronic packages are not fully characterized or understood, especially at device length scales wherein properties may differ significantly from bulk or literature values

Trusted AI framework for a new class of Standard Reference Materials and Data with exquisitely characterized uncertainty for billions of properties

Ongoing

The measurement of diverse molecular classes in biospecimens containing millions of molecules, known as omics, is increasingly important in the life sciences and medicine, and used to find novel cancer therapeutics, discover COVID-19 infection pathways, and diagnose diseases. NIST RMs and SRDs for

Uniform Unit Pricing: Tools for Consumers to Fight Shrinkflation

Ongoing

What is Unit Pricing? The pricing of goods based on the cost per unit of measure is commonly known as unit pricing. A unit price label often displays the product name and size, the price, the price per unit (e.g., how much you pay per gram, liter, or ounce), and other information. Unit pricing is

Vision science

Ongoing

NIST has been providing physical measurement standards in photometry and colorimetry for many years. However, the definitions of photometric and colorimetric units and standards are often questioned or found to be insufficient for modern lighting technologies. Large discrepancies between

Vitamin D Metabolites Quality Assurance Program (VitDQAP)

Completed

Interlaboratory comparison studies of the VitDQAP supported the reliability of vitamin D measurements, including determination of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, and 3- epi-25-hydroxyvitamin D3 in human serum and plasma. Results from the comparison studies helped participants to make

Wastewater Surveillance

Ongoing

NIST is partnering with the Department of Homeland Security Science and Technology Directorate (DHS/S&T) to develop documentary standards and reference materials to support an enduring capability in wastewater surveillance. Ongoing activities include: Development of a research grade test material

Photo of cars on Kosciuszko Bridge in New York

Weigh-In-Motion Scale Systems: Protecting the Nation’s Aging Infrastructure

Ongoing

NIST OWM is responsible for promoting uniform standards of weights and measures to facilitate commerce. OWM works in cooperation with States and the private sector to develop uniform weights and measures laws, regulations, device requirements, and test procedures, including the published legal

WG3 Analytical Methods

Ongoing

Standard(s) Under Development ISO/WD 20391-1: Biotechnology - Cell Counting – Part 1. General Guidance on Cell Counting Methods ISO/WD 20391-2: Biotechnology - Cell Counting – Part 2. Experimental Design and Statistical Analysis to Quantify Counting Method P erformance ISO/AWI 20395: Quality

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