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Material Measurement Laboratory

Projects/Programs

Displaying 176 - 200 of 576

Flow Cytometry Lab

Ongoing
Current Capabilities ERF value assignment measurement service for traceable ERF value assignment to microparticles, Aseptic sorting of cell lines, and primary cells Quantitative measurements of cell surface and intracellular biomarkers by estimating antibody bound per cell Accurate enumeration of...
NMR-Tubes

Fluid Phase Nuclear Magnetic Resonance (NMR) Spectroscopy

Ongoing
In-situ vapor-liquid equilibrium (VLE). We are applying vapor-phase NMR to measure VLE in-situ . We are currently applying this methodology to industrially important systems such as refrigerants and natural gas. The most widely used refrigerants have high global warming potential. Drop-in...

Fluid Suspensions and Emulsions

Ongoing
We aim to: Develop measurement capabilities to relate solution structure and viscosity through novel combinations of unique small volume, high shear rate rheometers with scattering and particle-imaging techniques. A major application of these capabilities is understanding self-association in fluids...
Fluorescence benchmarking

Fluorescence Microscopy Benchmarking: Overview

Completed
A challenge in using microscopy is how to compare and validate data from different instruments, and how to determine that the microscope performance today is the same as yesterday. NIST is developing a practical, automated approach to implementing performance benchmarking methods that will...
Food Nutrition Safety QAP

Food Nutrition and Safety Measurements Quality Assurance Program (FNSQAP)

Ongoing
As part of a revamp of QAPs in 2021, NIST established the FNSQAP to support the NIST Food Safety Program and Measurements and Standards to Support Nutrition Labeling. Participants measure nutrient components (e.g., minerals, vitamins, fatty acids, dietary fiber) and contaminants (e.g., toxic...

Forensic Chemistry

Ongoing
ProGRAM Overview The Forensic Chemistry Measurement Research Program is focused on addressing the following measurement and operational challenges: Need for approaches to improve workflow efficiency to reduce backlogs. Need for algorithms, data, and methodologies to increase the confidence of...
The inside of a DNA extraction robot hold tube in a rack

Forensic Genetics

Ongoing
Since the late 1980s, NIST has had scientists involved in DNA testing (aka "DNA Fingerprinting"). Early concerns over measurement accuracy and poor quality control of forensic DNA tests caused the Department of Justice to call upon NIST scientists to help with standards development and technology...
Photograph of a labeled amber bottle containing SRM 2683c Bituminous Coal.

Fossil Fuel Standard Reference Materials

Ongoing
The regulatory requirements with respect to air quality and fossil fuel specifications are continually changing, and consequently the associated measurement needs of the fossil fuel energy industries also change. For example, in recent years there has been a dramatic reduction in the allowable...
Logo for Free Energy and Advanced Sampling Simulation Toolkit (FEASST)

Free Energy and Advanced Sampling Simulation Toolkit (FEASST)

Ongoing
Intended Impact While flat-histogram Monte Carlo simulations have been shown to be a promising method for the direct calculation of complex fluid phase behavior with a variety of applications, most open-source Monte Carlo simulation packages do not support this method. We have therefore made FEASST...

Fundamental Interaction Mechanisms of Engineered Nanomaterials with DNA

Completed
Intended impact Nanotechnology research has resulted in the rapid creation of engineered nanomaterials with many foreseeable applications in medical imaging/diagnosis and in drug delivery. However, there is a notable scarcity of both acute and chronic human toxicity data for these new materials...

Fundamentals of Deformation

Ongoing
• We have provided general users from industry, academia and national laboratories with a completely new class of X-ray imaging techniques for materials studies (ultra-small-angle X-ray scattering imaging), that we developed from basic concept to DOE-supported operations at the Advanced Photon...

Future Directions for Magnetic Sensors

Completed
Bringing new or improved magnetic sensors to market requires modeling for rapid assessment of the effect of new designs or improved materials properties. To this end, we are investigating the fundamental properties of a new class of magnetic sensors that is rapidly displacing ones based on older...
Photograph of SRM SRM 1694a sulfur dioxide in nitrogen showing a labeled gas cylinder.

Gas Concentration Standards Supporting Atmospheric Monitoring

Ongoing
NIST develops suites of SI-traceable, amount-of-substance, primary gas standard mixtures (PSMs) for key trace and greenhouse gas species to provide traceability to the International System of Units for a range of user communities. Standard Reference Materials (SRMs), certified to the PSMs, are...

Gene Delivery Systems

Ongoing
Viral Vectors Viral vectors are a critical tool for delivering DNA or RNA into patient’s cells. Common viral vectors for gene therapy include adenovirus, lentivirus, and adeno associated virus. Administration of viral vectors can occur in vivo or ex vivo , such as for adeno associated virus or...
GIAB Logo

Genome in a Bottle

Ongoing
Consortium goals: The Genome in a Bottle Consortium is a public-private-academic consortium hosted by NIST to develop the technical infrastructure (reference standards, reference methods, and reference data) to enable translation of whole human genome sequencing to clinical practice and innovations...
Photo of broken laminated windshield glass

Glass Evidence Analysis

Ongoing
Quantitative XRF Glass Database Recent research efforts in the forensic trace field have focused on the development of databases to assign a significance to forensic evidence (i.e., to report the strength of an association or exclusion). In the forensic analysis of glass using µ-XRF, samples are...
13 tubes each containing an individual glycan in SRM 3655

Glycan Standard Reference Materials

Ongoing
Now Available A glycan-based NIST Standard Reference Material ( SRM 3655 Glycans in Solution ) supports the biomanufacturing and protein therapeutics communities with a set of 13 individually-bottled, pure glycoforms including those most commonly observed as N-linked glycans on therapeutic...
GutMicrobiome

Gut Microbiome Metabolomics Interlaboratory Program

Ongoing
On behalf of the Biosystems and Biomaterials and Chemical Sciences Divisions at the National Institute of Standards and Technology (NIST), we would like to thank you for your interest in our new Gut Microbiome Metabolomics Program. As part of the larger NIST Microbiome Program, this metabolomics...
Picture for Hardness and Coating Thickness Standardization and Measurements Project Including Equipment and Standards Organizations

Hardness Standardization and Measurements

Ongoing
DESCRIPTION Purpose: Provide measurement traceability for the Knoop, Rockwell, and Vickers hardness scales and for coating thickness measurements that are based on magnetic methods. Goals: Harmonization of hardness and coating thickness testing protocols, in pursuit of reduction of measurement...
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