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Search Publications by: Brittany A. Broder (Fed)

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Displaying 1 - 3 of 3

Efficient Synthesis and HPLC-Based Characterization for Developing Vanadium-48-Labeled Vanadyl Acetylacetonate as a Novel Cancer Radiotracer for PET Imaging

February 9, 2024
Author(s)
Brittany Broder, Mohammed Bhuiyan, Richard Freifelder, David Rotsch, Satish Chitneni, Marvin William Makinen, Chin-Tu Chen
Bis(acetylacetonato)oxidovanadium(IV) [(VO(acac)2], generally known as vanadyl acetylacetonate, has been shown to be preferentially sequestered in malignant tissue. Vanadium-48 (48V) generated with a compact medical cyclotron has been used to label VO(acac

Accelerator-Based Production of Scandium Radioisotopes for Applications in Prostate Cancer: Toward Building a Pipeline for Rapid Development of Novel Theranostics

August 13, 2023
Author(s)
Jason Meier, Hannah Zhang, Richard Freifelder, Mohammed Bhuiyan, Phillip Selman, Megan Mendez, Pavithra Kankanamalage, Thomas Brossard, Antonino Pusateri, Hsiu-Ming Tsai, Lara Leoni, Sagada Penano, Kaustab Ghosh, Brittany Broder, Erica Markiewicz, Amy Renne, Walter Stadler, Ralph Weichselbaum, Jerry Nolen, Chien-Min Kao, Satish Chitneni, David Rotsch, Russell Szmulewitz, Chin-Tu Chen
In the field of nuclear medicine, the β+ emitting 43Sc and β- emitting 47Sc are promising candidates in cancer diagnosis and targeted radionuclide therapy (TRT) due to their fa-vorable decay schema and shared pharmacokinetics as a true theranostic pair