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Search Publications by: Ryan Evans (Fed)

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Displaying 1 - 5 of 5

Diffusion-limited reactions in nanoscale electronics

September 22, 2020
Author(s)
Ryan Evans, Arvind Balijepalli, Anthony J. Kearsley
To quantify interactions between drug molecules and target receptors, a novel nanoscale electronics instrument is under development. The instrument consists of two regions: a biological region, and an electronics region. The biological region consists of a

Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics

January 1, 2019
Author(s)
Robert G. Brinson, John P. Marino, Frank Delaglio, Luke W. Arbogast, Ryan M. Evans, Anthony J. Kearsley, Yves Aubin, Gregory Pierens, Xinying Jia, David Keizer, Jonas Stahle, Goran Widmalm, Chad Lawrence, Patrick Reardon, John Cort, Koichi Kato, Stuart Parnham, Andreas Blomgren, Torgny Rundlof, Kang Chen, David Keire, Thea Suter-Stahel, Gerhard Wider, Donna Baldisseri, Julie Wu, Mats Wikstrom, Medhi Mobli
Of the top ten drugs on the global market in 2016, seven of them are biologics with a combined market value of over US$60 billion. Moreover, around 2,800 biopharmaceuticals, many of them monoclonal antibodies (mAbs), are in some stage of clinical

Transport Effects on Multiple-Component Reactions in Optical Bionsensors

August 1, 2017
Author(s)
Ryan M. Evans, David A. Edwards
Many biochemical reactions involve a stream of chemical reactants (ligand molecules) flowing over a surface to which other reactants (receptors) are confined. Scientists measure rate constants associated with these reactions in an optical biosensor: an

Receptor heterogeneity in optical biosensors

July 13, 2017
Author(s)
David A. Edwards, Ryan Evans
Many biochemical reactions in nature involve a stream of chemical reactants (ligand molecules) flowing over a surface to which other reactants (receptors) are confined. Scientists measure rate constants associated with these reactions in an optical