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Search Publications by: Elizabeth Kelley (Fed)

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Displaying 1 - 25 of 45

Vitamin E Acetate Causes Softening of Pulmonary Surfactant Membrane Models

February 19, 2025
Author(s)
Mitchell DiPasquale, Maksymilian Dziura, Omotayo Gbadamosi, Stuart R. Castillo, Ambreen Fahim, Justin Roberto, Jeffrey Atkinson, Natalie Boccalon, Mario Campana, Sai Pingali, P. C. Chandrasekera, Piotr Zolnierczuk, Michihiro Nagao, Elizabeth Kelley, Drew Marquardt
The popularity of electronic cigarettes and vaping products has launched the outbreak of a condition affecting the respiratory system of users, known as electronic-cigarette/vaping-associated lung injury (EVALI). The build-up of vitamin E acetate (VEA), a

Linking Chemical Degradation and Physical Instability of Lipid Vesicles

January 1, 2025
Author(s)
Sharareh Rezaei, Emily Blick, Kenneth Mineart, Elizabeth Kelley
Lipid vesicles are applicable in a wide variety of uses including both academic and commercial avenues. In all of these cases, it is crucial to understand and connect the chemical degradation of constituent molecules – i.e., lipids – with the physical

Effect of Micellar Morphology on the Temperature-Induced Structural Evolution of ABC Polypeptoid Triblock Terpolymers into Two-Compartment Hydrogel Network

June 28, 2024
Author(s)
Naisheng Jiang, Tianyi Yu, Meng Zhang, Bailee Barrett, Haofeng Sun, Jun Wang, Ying Luo, Garrett Sternhagen, Sunting Xuan, Guangcui Yuan, Elizabeth Kelley, Shuo Qian, Peter Bonnesen, Kunlun Hong, Dongcui Li, Donghui Zhang
We investigated the temperature-dependent structural evolution of thermoreversible triblock terpolypeptoid hydrogels, namely poly(N-allyl glycine)-b-poly(N-methyl glycine)-b-poly(N-decyl glycine) (AMD), using small-angle neutron scattering (SANS) with

Effect of Micellar Morphology on the Temperature-Induced Structural Evolution of ABC Polypeptoid Triblock Terpolymers into Two-Compartment Hydrogel Network

June 28, 2024
Author(s)
Naisheng Jiang, Tianyi Yu, Meng Zhang, Bailee Barrett, Haofeng Sun, Jun Wang, Ying Luo, Garrett Sternhagen, Sunting Xuan, Guangcui Yuan, Elizabeth Kelley, Shuo Qian, Peter Bonnesen, Kunlun Hung, Donghui Zhang
We investigated the temperature-dependent structural evolution of thermoreversible triblock terpolypeptoid hydrogels, namely poly(N-allyl glycine)-b-poly(N-methyl glycine)-b-poly(N-decyl glycine) (AMD), using small-angle neutron scattering (SANS) with

Dynamic Structure Factor of Undulating Vesicles: Finite-Size and Spherical Geometry Effects with Application to Neutron Spin Echo Experiments

February 14, 2024
Author(s)
Rony Granek, Ingo Hoffmann, Elizabeth Kelley, Michihiro Nagao, Petia Vlahovska, Anton Zilman
We consider the dynamic structure factor (DSF) of quasi-spherical vesicles and present a generalization of an expression that was originally formulated by Zilman and Granek (ZG) for scattering from isotropically oriented quasi-flat membrane plaquettes. The

A thermodynamic analysis of CLC transporter dimerization in lipid bilayers

October 10, 2023
Author(s)
Rahul Chadda, Taeho Lee, Robyn Mahoney-Kruszka, Elizabeth Kelley, Nathan Bernhardt, Priyanka Sandal, Janice Robertson
The CLC-ec1 chloride/proton antiporter is a membrane-embedded homodimer with subunits that can dissociate and associate, but the thermodynamic driving forces favor the assembled dimer at biological densities. Yet, the physical reasons for this stability

Investigating the Cut-off Effect of n-alcohols on Lipid Movement: A Biophysical Study

July 5, 2023
Author(s)
Michael H. Nguyen, Dominik Dziura, Mitchell DiPasquale, Stuart R. Castillo, Elizabeth Kelley, Drew Marquardt
Cellular membranes are responsible for absorbing the effects of external perturbants for the cell's survival. Such perturbants include small ubiquitous molecules like n-alcohols which were observed to exhibit anesthetic capabilities, with this effect

Mitocans Induce Lipid Flip-Flop and Permeabilize the Membrane to Signal Apoptosis

June 6, 2023
Author(s)
Stuart R. Castillo, Michael H. Nguyen, Mitchell DiPasquale, Elizabeth Kelley, Drew Marquardt
Pancratistatin (PST) and narciclasine (NRC) are natural therapeutic agents which exhibit specificity towards the mitochondria of cancerous cells and initiate apoptosis. Unlike traditional cancer therapeutic agents, PST and NRC are effective, targeted, and

Investigating the Effect of Medium Chain Triglycerides on the Elasticity of Pulmonary Surfactant

April 17, 2023
Author(s)
Dominik Dziura, Stuart R. Castillo, Mitchell DiPasquale, Omotaya Gbadamosi, Piotr Zolnierczuk, Michihiro Nagao, Elizabeth Kelley, Drew Marquardt
In recent years, vaping has increased in both popularity and ease of access. This has led to an outbreak of a relatively new condition known as e-cigarette/vaping-associated lung injury (EVALI). This injury can be caused by physical interactions between

Nanoscale Bending Dynamics in Mixed-Chain Lipid Membranes

January 9, 2023
Author(s)
Elizabeth Kelley, Moritz Frewein, Orsolya Czakkel, Michihiro Nagao
Lipids that have two tails of different lengths are found throughout biomembranes in nature, yet the effects of this asymmetry on the membrane properties, are not well understood, especially when it comes to the membrane dynamics. Here we study the

Vitamin E does not Disturb Polyunsaturated Fatty Acid Lipid Domains

November 1, 2022
Author(s)
Mitchell DiPasquale, Michael H. Nguyen, Stuart R. Castillo, Isabelle J. Dib, Elizabeth Kelley, Drew Marquardt
The antioxidant function of vitamin E in biomembranes remains a prominent topic of discussion. As its limitations as an antioxidant persist and novel functions are discovered, our understanding of the role of vitamin E becomes increasingly enigmatic. As a

a-Synuclein Interaction with Lipid Bilayer Discs

August 23, 2022
Author(s)
Marija Dubackic, Yun Liu, Elizabeth Kelley, Crispin Hetherington, Michael Haertlein, Juliette Devos, Sara Linse, Emma Sparr, Ulf Olsson
α-Synuclein (aSyn) is a 140 residue long protein that is present in presynaptic termini of nerve cells. The protein is also pathologically associated with Parkinson's disease, where it has been found to self-assemble into long amyloid fibrils forming

Probing the Link between Pancratistatin and Mitochondrial Apoptosis through Changes in the Membrane Dynamics on the Nanoscale

June 6, 2022
Author(s)
Stuart R. Castillo, Brett W. Rickeard, Mitchell DiPasquale, Michael H. Nguyen, Aislyn Lewis-Laurent, Milka Doktorova, Batuhan Kav, Markus S. Miettinen, Michihiro Nagao, Elizabeth Kelley, Drew Marquardt
Pancratistatin (PST) is a natural antiviral alkaloid that has demonstrated specificity towards cancerous cells and explicitly targets the mitochondria. PST initiates apoptosis while leaving healthy, noncancerous cells unscathed. However, the manner by

The Very Small-Angle Neutron Scattering Instrument at the National Institute of Standards and Technology

April 1, 2022
Author(s)
John Barker, James Moyer, Steven Kline, G. Jensen, Jeremy Cook, Cedric Gagnon, Elizabeth Kelley, Jean Philippe Chabot, Nicholas C. Maliszewskyj, Chirag Parikh, Wangchun Chen, Ryan Murphy, C. Glinka
A description and the performance of the Very Small-Angle Neutron Scattering (VSANS) Diffractometer at the National Institute of Standards and Technology are presented. The measurement range of the instrument extends over three decades of momentum transfer

Transformation of Lipid Vesicles into Micelles by Adding Nonionic Surfactants: Elucidating the Structural Pathway and the Intermediate Structures

March 24, 2022
Author(s)
Igor K. Mkam Tsengam, Marzhana Omarova, Elizabeth Kelley, Alon V. McCormick, Geoffrey D. Bothun, Srinivasa R. Raghavan, Vijay T. John
The phospholipid lecithin (L) and the nonionic surfactant Tween 80 (T) are used together in various contexts, including in drug delivery and oil spill remediation. There is hence a need to elucidate the nanostructures in L/T mixtures, which is the focus of

Relationship between Viscosity and Acyl Tail Dynamics in Lipid Bilayers

August 12, 2021
Author(s)
Michihiro Nagao, Elizabeth Kelley, Antonio Faraone, Makina Saito, Yoshitaka Yoda, Masayuki Kurokuzu, Shinichi Takata, Makoto Seto, Paul Butler
Membrane viscosity is a fundamental property that controls molecular transport and structural rearrangements in lipid membranes. Given its importance in many cell processes, various experimental and computational methods have been developed to measure the

Collective Dynamics in Lipid Membranes Containing Transmembrane Peptides

June 21, 2021
Author(s)
Elizabeth Kelley, Paul Butler, Michihiro Nagao
Biological membranes are composed of complex mixtures of lipids and proteins that influence each other's structure and function. The biological activities of many channel-forming peptides and proteins are known to depend on the material properties of the

Membrane transporter dimerization driven by differential lipid solvation energetics of dissociated and associated states

April 7, 2021
Author(s)
Rahul Chadda, Nathan Bernhardt, Elizabeth Kelley, Susana Marujo Teixeira, Kacie Griffith, Alejandro Gil-Ley, Tugba Ozturk, Lauren Hughes, Ana Forsythe, Venkatramanan Krishnamani, Jose Faraldo-Gomez, Janice Robertson
Over two-thirds of integral membrane proteins of known structure assemble into oligomers. Yet, the forces that drive the association of these proteins remain to be delineated, as the lipid bilayer is a solvent environment that is both structurally and
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