Kumari, P.
, Faraone, A.
, Kelley, E.
and Benedetto, A.
(2021),
Stiffening Effect of the [Bmim][Cl] Ionic Liquid on the Bending Dynamics of DMPC Lipid Vesicles, Journal of Physical Chemistry B
(Accessed April 26, 2024)
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Stiffening Effect of the [Bmim][Cl] Ionic Liquid on the Bending Dynamics of DMPC Lipid Vesicles
Published
Author(s)
Pallavi Kumari, , , Antonio Benedetto
Abstract
Cell membranes play a crucial role for life. They are involved, for example, in cell migration and recognition. Lipids, organized in a bilayer structure, are one of their major constituents. Alterations in the lipid-bilayer elasticity can lead to cell malfunction and has been observed in several pathological conditions. Complementarily, chemical-physical manipulations of the lipid-bilayer elasticity hold the promise of effective therapeutic and diagnostic approaches. Due to their proven strong-interaction with lipid-bilayers, ionic liquids (ILs) may play an important role. This work focuses on the effect of the imidazolium-IL [bmim][Cl] on the elasticity of model DMPC-lipid bilayers. Here, by combining small-angle neutron scattering and neutron spin-echo, we show that the IL, dispersed at the bilayer-water interface, (i) diffuses into the lipid region accounting for five IL-cations for every eleven lipids, and (ii) causes a temperature-dependent increase of the lipid-bilayer bending elasticity, up to 60% compared to the neat lipid-bilayer at 40 °C.Citation
Journal of Physical Chemistry B
Volume
125
Issue
26
Pub Type
Journals
Keywords
ionic liquids, lipid-bilayer elasticity, cell membrane elasticity, neutron spin-echo, small angle neutron scattering
Citation
Created July 7, 2021, Updated September 21, 2021