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Search Publications by: Edward Sisco (Fed)

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Displaying 51 - 75 of 90

Forensic Applications of DART-MS: A Review of Recent Literature

June 17, 2021
Author(s)
Edward Sisco, Thomas Forbes
The need for rapid chemical analyses and new analytical tools in forensic laboratories continues to grow due to case backlogs, difficult to analyze cases, and identification of previously unseen materials such as new psychoactive substances. To adapt to

The use of lateral flow immunoassays for the detection of fentanyl in seized drug samples and postmortem urine

June 17, 2021
Author(s)
Daniel J. Angelini, Tracey Biggs, Amber M. Prugh, Jessica A. Smith, Jennifer A. Hanburger, Bob Llano, Raquel Avelar, Angela Ellis, Brady Lusk, Abdallah Naanaa, Edward Sisco, Jennifer W. Sekowski
The opioid crisis has continued to progress in the United States and the rest of the world. As this crisis continues, there is a pressing need for a rapid and cost-effective method for detecting fentanyl. Recent studies have suggested that lateral flow

Optimization of Confined DART-MS

February 14, 2020
Author(s)
Edward R. Sisco, Matthew E. Staymates, Thomas P. Forbes
The use of direct analysis in real time mass spectrometry (DART-MS) is seeing increased use in a number of fields, including forensic science, environmental monitoring, food safety, and healthcare. With the increased use, novel configurations have been

A Multi-Laboratory Investigation of Drug Background Levels

September 9, 2019
Author(s)
Edward R. Sisco, Marcela N. Najarro
Identifying, quantifying, and analyzing the drug background in operational environments such as forensic laboratories is an emerging body of research. Understanding these levels can provide critical information to address issues like occupational exposure

Understanding the Impact of Drug Background Levels in Forensic Laboratories

August 13, 2019
Author(s)
Edward Sisco, Marcela N. Najarro, Amber Burns, Robert Kirkby
As drugs become increasingly potent and analytical instrumentation becomes more sensitive, the need to understand and monitor drug background levels is becoming imperative. Background monitoring is commonplace in many other industries but has been largely

Evaluation of a lateral flow immunoassay for the detection of the synthetic opioid fentanyl

April 26, 2019
Author(s)
Edward Sisco, Daniel J. Angelini, Tracey D. Briggs, Michele N. Maughan, Michael G. Feasel, Jennifer W. Sekowski
In the United States in 2016, 64,000 overdose deaths were reported to be associated with the abuse of opioids, including prescription painkillers (e.g. oxycodone), opiates (e.g. heroin), or synthetic opioids (e.g. fentanyl). The recent spike in the

Review of the National Institute of Standards and Technology Research Program in Trace Contraband Detection

April 14, 2019
Author(s)
J Greg Gillen, Jennifer R. Verkouteren, R. Michael Verkouteren, Marcela Najarro, Edward Sisco, Matthew Staymates, Jessica L. Staymates, Robert A. Fletcher, Jeffrey Lawrence, Elizabeth Robinson, Alexander T. Bulk, Joe Bennett, Shin Muramoto, Thomas Forbes
Current national priorities in homeland security have led to an unprecedented level of utilization of explosives trace detection (ETD) systems for counterterrorism and law enforcement. Despite the widespread deployment of ETD instruments at airports

ASTM E2677: Web-based International Standard on Limit of Detection for Explosive Trace Detectors (and More) - Opioids and Ozone

February 12, 2019
Author(s)
R M. Verkouteren, Nathanael A. Heckert, Stefan D. Leigh, Edward R. Sisco, James E. Norris, Jeffrey A. Lawrence, Amber Burns
The performance characteristics of explosive and narcotic trace detectors are mission-critical to agencies worldwide that are charged with protection of the public, defense for mass transit and infrastructure, and the safety of first responders. Commercial

A Method for Measuring the Quantity of Drugs on Surfaces in a Forensic Laboratory

September 19, 2018
Author(s)
Edward R. Sisco, Marcela N. Najarro, Amber Burns
While background studies have been commonplace in many occupational fields for a long time, attempts to understand the chemical background in forensics labs has been largely understudied. However, given the increasing sensitivity of instrumentation and

Recent Advances in Ambient Mass Spectrometry of Trace Explosives

May 6, 2018
Author(s)
Thomas Forbes, Edward Sisco
Ambient mass spectrometry has evolved rapidly over the past decade, yielding a plethora of platforms and demonstrating scientific advancements across a range of fields from biological imaging to rapid quality control. These techniques have enabled real

Strategies and Considerations for the Trace Detection of Fentalogs

October 26, 2017
Author(s)
Edward Sisco
Fentanyl and fentanyl analogs pose a significant and ever changing threat in the United States as both pure compounds and in complex mixtures. While commonly considered detection techniques require visible amounts of powder (i.e. color tests or GC/MS

DART-MS analysis of inorganic explosives using high temperature thermal desorption

May 4, 2017
Author(s)
Thomas P. Forbes, Edward R. Sisco, Matthew E. Staymates, John G. Gillen
An ambient mass spectrometry (AMS) platform coupling Joule heating thermal desorption (JHTD) and direct analysis in real time (DART) was developed, generating discretely pulsed rapid heating ramps and elevated temperatures for the detection of inorganic

Rapid Detection of Fentanyl, Fentanyl Analogues, and Opioids for on-Site or Laboratory Based Drug Seizure Screening using Thermal Desorption DART-MS and Ion Mobility Spectrometry

April 27, 2017
Author(s)
Edward Sisco, Jennifer R. Verkouteren, Jessica L. Staymates, Jeffrey Lawrence
Fentanyl and fentanyl analogues represent a current and emerging threat in the United States as pure illicit narcotics and as cutting agents with heroin. Because of their extreme potency, methods to safely and rapidly detect these compounds are of high
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