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Displaying 1 - 19 of 19

Methods for Characterization of Bioactivity Using Confocal Microscopy

December 1, 2020
Author(s)
Jirun Sun, Nancy Lin, Joy Dunkers, Sheng Lin-Gibson
One common tissue engineering approach for regenerating or replacing damaged tissues involves a porous polymeric scaffold. The scaffolds serve as the mechanical framework for cell attachment and growth, and generate an environment with features that span

Short-time dental resin biostability and kinetics of enzymatic degradation

May 9, 2018
Author(s)
Xiaohong Wang, Sheng Song, Lei Chen, Christopher M. Stafford, Jirun Sun
Resin biostability is an important concern regarding the durability of methacrylate-based dental resin restorations. Current resin biostability evaluation methods take considerable time, from weeks to months, and provide no short-time kinetics of resin

Acid-induced and pH-controlled Reversible Switching of Broad-Spectrum Antibacterial Activity

February 13, 2018
Author(s)
Yin Y. Nelson, Vytautas Reipa, Xiaohong Wang, Kenneth Mineart, Vivek M. Prabhu, Nancy J. Lin, Jirun Sun
Bacterial resistance to antimicrobials is threatening millions of human lives due to indiscriminate overuse and environmental build-up of antibiotics. We present the smart regulation of antibacterial activity in biologically relevant conditions to reduce

Experimental and statistical methods to evaluate antibacterial activity of a quaternary pyridinium salt on planktonic, biofilm-forming, and biofilm states

March 3, 2017
Author(s)
Daneli Lopez-Perez, Paula J. Baker, Adam L. Pintar, Jirun Sun, Nancy Lin, Sheng Lin-Gibson
Robust evaluation and comparison of antimicrobial technologies are critical to improving biofilm prevention and treatment. Herein, a multi-pronged experimental framework and statistical models were applied to determine the effects of quaternary pyridinium

Biophysical Characterization of Functionalized Titania Nanoparticles and Their Application in Dental Adhesives

February 2, 2017
Author(s)
Jirun Sun, Elijah J. Petersen, Stephanie S. Watson, Christopher M. Sims, Alexander Kassman, Stanislav A. Frukhtbeyn, Drago Skrtic, Meryem T. Ok, Deborah S. Jacobs, Qiang Ye, Bryant C. Nelson
It is demonstrated that carboxylic acid-functionalized titanium dioxide (TiO2) NPs produce significantly higher levels of reactive oxygen species (ROS) after visible light irradiation (400–800 nm, 1600 mW/cm2) in comparison to nonfunctionalized TiO2 NPs

An azeotropic cross-linked styrene-methacrylate network formed through rapid visible-light photo- polymerization

July 15, 2016
Author(s)
Yin Yang, Aaron A. Urbas, Andres Gonzalez-Bonet, Richard J. Sheridan, Jonathan E. Seppala, Kathryn L. Beers, Jirun Sun
A system containing well-defined functional material, a clinically practical procedure to make the material in situ, and proper analytical tools for chemical structure and kinetic studies is appealing, but currently unavailable. Herein, we introduce an all

Tuning photo-catalytic activities of TiO2 nanoparticles using dimethacrylate resins

August 20, 2015
Author(s)
Jirun Sun, Stephanie S. Watson, David Allsopp, Deborah Jacobs, Drago Skrtic
Unique photo-catalytic activities (PCAs) of titanium dioxide nanoparticles (TiO2 NPs) made them attractive in many potential applications for medical devices. This study examined the benefits of the PCAs of TiO2 NPs through functionalization of the TiO2

Effects of Polymeric Nanogratings on Cell Orientation

December 30, 2010
Author(s)
Nancy J. Lin, Sheng Lin-Gibson, Jirun Sun, Yifu Ding
Surface topography is known to play a critical role in the biological response to materials, with surface features on the order of both microns and nanometers altering cell response, including morphology, adhesion, cytoskeletal orientation, and gene

Cell Contact Guidance in Response to Nanopattern Shape and Height

October 18, 2010
Author(s)
Sheng Lin-Gibson, Jirun Sun, Nancy J. Lin, Jing N. Zhou, Hyun W. Ro, Christopher L. Soles, Marcus T. Cicerone, Yifu Ding
Understanding the correlation between cell contact guidance (CG) and nanoscale surface features is vital in designing advanced medical devices to manipulate cell behaviors. Nanoscale surface features that mimic extracellular matrix are critical

Thermodynamic Underpinnings of Cell Alignment on Controlled Topographies

August 17, 2010
Author(s)
Yifu Ding, Jirun Sun, Hyun W. Ro, Zhen Wang, Jing N. Zhou, Nancy J. Lin, Sheng Lin-Gibson, Marcus T. Cicerone, Christopher L. Soles
Cells sense and respond to the chemical, topographical, and mechanical features of their substrate and extracellular matrix. Shape and locomotive response to these features is termed contact guidance (CG) and is of vital importance in understanding many

Microstructure and Mineral Composition of Dystrophic Calcification Associated with the Idiopathic Inflammatory Myopathies

October 26, 2009
Author(s)
Naomi Eidelman, A Boyde, A.J. Bushby, P.G.T. Howell, Jirun Sun, F.W. Miller, P Robey, Lisa Rider
Calcified deposits are present in 30% of children with juvenile dermatomyositis (JDM) and less frequently in adult dermatomyositis (DM). This study aimed to determine the microstructure, composition and stiffness of these deposits. Specimens were analyzed

Myocardial Calcification in Captive Grouper Epinephelus Aeneus

June 1, 2009
Author(s)
Naomi Eidelman, A Colorni, Jirun Sun, M.C. Fishbein, A Diamant
A case of myocardial calcification is described in the Mediterranean white grouper, Epinephelus aeneus, cultured as broodstock in Eilat (Israel, Red Sea). Large calcified nodules and scar tissue were observed in the ventricular tissues. The chemical

Monitoring Alignment of Osteoblast Cells Directed by Gradient Nanopatterns

April 6, 2008
Author(s)
Jirun Sun, Yifu Ding, Nancy J. Lin, Hyun Wook Ro, Christopher L. Soles, Sheng Lin-Gibson
We investigated the behavior of pre-osteoblasts cultured on polystyrene and photopolymerized ethoxylated bisphenol-A dimethacrylate gradient patterns. Gradient patterns varying in height from several hundred to 0 nm were prepared using nanoimprinting

Mapping Cell Distribution in Amorphous Scaffolds using Confocal Microscopy

August 19, 2007
Author(s)
Jirun Sun, Nancy Lin, Marcus T. Cicerone, Sheng Lin-Gibson
One common method for probing cell-material interactions is direct visualization via confocal laser scanning microscopy, a technique widely used for studying biological systems. However, confocal microscopy has limited depth penetration for imaging cells