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Search Publications by: Tae Joon Cho (Fed)

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Displaying 1 - 25 of 32

Chemical heterogeneity observed in the development of photo-oxidized PET micro- and nanoparticle weathered controls

February 19, 2025
Author(s)
John Pettibone, Eric S. Windsor, Tae Joon Cho, Thomas Forbes, Ying Tung Kuo, Justin Gorham, Li Piin Sung, Song-Syun Jhang
Determining unknown secondary micro and nanoplastic (MNP) composition remains a persistent analytical challenge for field collected samples. The availability of material standards should accelerate method development for improved identification. Here

Well characterized polyethyleneimine/carboxylated polyethylene glycol functionalized gold nanoparticles as prospective nanoscale control materials for in vitro cell viability assays: particle characterization and toxicity test in eight mammalian cell line

January 7, 2025
Author(s)
Vytas Reipa, Vincent Hackley, Alessandro Tona, Min Beom Heo, Ye Ryeong Lee, Tae Geol Lee, Aaron Johnston-Peck, Tae Joon Cho
Safety screening of manufactured nanomaterials (MNMs) is essential for their adoption by consumers and the marketplace. Lately, animal-based testing is replaced by mechanistically informative in vitro assays due to requirements of regulatory agencies. Cell

Hyperspectral dark-field microscopy of human breast lumpectomy samples for tumor margin detection in breast-conserving surgery

May 7, 2024
Author(s)
Jeeseong Hwang, Philip Cheney, Stephen Kanick, Hanh Le, David McClatchy, Helen Zhang, John Lu, Tae Joon Cho, Kimberly Briggman, David W. Allen, Wendy A. Wells, Brian Pogue
Hyperspectral dark-field microscopy (HSDFM) and data cube analysis algorithms demonstrate successful classification of various tissue types, including the detection of carcinoma regions in human post-lumpectomy breast tissues excised during breast

Stability-Enhanced Cisplatin Gold Nanoparticles as Therapeutic Anticancer Agents

December 22, 2023
Author(s)
Tae Joon Cho, Vytas Reipa, John Pettibone, Justin Gorham, Allesandro Tona, Aaron Johnston-Peck, Bryant C. Nelson, Vincent Hackley
Using dendron chemistry, we developed stability-enhanced carboxylate surfacemodified (negatively charged dendron) AuNPs (Au-NCD). Since the carboxylate surface of Au- NCD is optimal for complexation with cisplatin (Pt) moieties, we further synthesized Pt

Polyethyleneimine/polyethylene glycol-conjugated gold nanoparticles as nanoscale positive/negative controls in nanotoxicology: Testing in frog embryo teratogenesis assay-Xenopus and mammalian tissue culture system

March 15, 2023
Author(s)
Vytas Reipa, Alessandro Tona, Feng Yi, Bryant C. Nelson, David A. LaVan, Vincent A. Hackley, Tae Joon Cho
Despite the great potential of using positively charged gold nanoparticles (AuNPs) in nanomedicine, no systematic studies have been reported on their synthesis optimization or colloidal stability under physiological conditions until a group at the National

Introduction of nanoscale positive controls for nanotoxicology: A new aspect of utilization of stability-enhanced Gold-Polyethyleneimine conjugates (Au-PEIs)

November 8, 2022
Author(s)
Tae Joon Cho, Vincent A. Hackley, Vytas Reipa, Alessandro Tona, Christopher Sims, Natalia Farkas
Polyethyleneimine (PEI) conjugated gold nanoparticles (Au-PEIs) have potential use as positively charged gold nanoparticles (AuNPs) for nanomedical applications, due to their cationic surface that promotes cellular uptake and gene transfection. We report

Preparation, Characterization, and Biological Activity of Stability-Enhanced Polyethyleneimine-Conjugated Gold Nanoparticles (Au-PEI@NIST) for Biological Application

September 16, 2021
Author(s)
Tae Joon Cho, Vincent A. Hackley, Feng Yi, David A. LaVan, Vytas Reipa, Alessandro Tona, Bryant C. Nelson, Christopher Sims, Natalia Farkas
In this special publication, we report on a modified synthetic process that results in a stable suspension of Au-PEI nanoparticles, Au-PEI@NIST. Synthesized materials were characterized using an orthogonal approach that included dynamic light scattering

Certification of Standard Reference Material(R) 1992 / ERM(R)-FD305 Zeta Potential - Colloidal Silica (Nominal Mass Fraction 0.15 %)

November 24, 2020
Author(s)
Yannic Ramaye, Vikram Kestens, J. Charoud-Got, S. Mazoua, G. Auclair, Tae Joon Cho, Blaza Toman, Vincent A. Hackley, T. Linsinger
This report describes the production of SRM 1992/ERM-FD305, silica particles suspended in a borate buffer, certified for electrophoretic mobility and zeta potential by electrophoretic light scattering (ELS). This material was produced following ISO 17034

Certification of Standard Reference Material(R) 1993 / ERM(R)-FD306 Zeta Potential - Colloidal Silica (Nominal Mass Fraction 2.2 %)

November 24, 2020
Author(s)
Yannic Ramaye, Vikram Kestens, J. Charoud-Got, S. Mazoua, G. Auclair, Tae Joon Cho, Blaza Toman, Vincent A. Hackley, T. Linsinger
This report describes the production of SRM 1993/ERM-FD306, silica particles suspended in a borate buffer, certified for electrophoretic mobility and zeta potential by electrophoretic light scattering (ELS). This material was produced following ISO 17034

Parallel multi-parameter study of PEI-functionalized gold nanoparticle synthesis for bio- medical applications: Part 2. Elucidating the role of surface chemistry and polymer structure on performance

November 10, 2020
Author(s)
Tae Joon Cho, Justin M. Gorham, John M. Pettibone, Jingyu Liu, Jiaojie Tan, Vincent A. Hackley
Despite the breadth and quality of published work in this area, it remains unclear how the specific properties of polyethyleneimine (PEI) and the methods utilized to conjugate it to gold nanoparticles (AuNPs) impact the final product morphology and

The certification of electrophoretic mobility/zeta potential of silica particles in aqueous solution: ERM-FD305/SRM 1992

October 27, 2020
Author(s)
Y. Ramaye, V. Kestens, J. Charoud-Got, S. Mazoua, G. Auclair, Tae Joon Cho, Blaza Toman, Vincent A. Hackley, T. Linsinger
This report describes the production of ERM-FD305/SRM 1992, silica nanoparticles suspended in a borate buffer, certified for electrophoretic mobility and zeta potential measurements by electrophoretic light scattering (ELS). This material was produced

The certification of electrophoretic mobility/zeta potential of silica particles in aqueous solution: ERM-FD306/SRM 1993

October 23, 2020
Author(s)
Yannic Ramaye, Vikram Kestens, J. Charoud-Got, S. Mazoua, G. Auclair, Tae Joon Cho, Blaza Toman, Vincent A. Hackley, T. Linsinger
This report describes the production of ERM-FD306/SRM 1993, silica nanoparticles suspended in a borate buffer, certified for electrophoretic mobility and zeta potential measurements. This material was produced following ISO Guide 17034:2016 and is

Parallel multi-parameter study of PEI-functionalized gold nanoparticle synthesis for bio-medical applications: Part 1. A critical assessment of methodology, properties and stability

August 20, 2019
Author(s)
Tae Joon Cho, Justin M. Gorham, John M. Pettibone, Jingyu Liu, Jiaojie Tan, Vincent A. Hackley
Cationic polyethyleneimine (PEI) conjugated gold nanoparticles (AuNPs) that are chemically and physically stable under physiological conditions are an ideal candidate for certain bio-medical applications, in particular DNA transfection. However, the

Discriminated properties of PEI functionalized gold nanoparticles (Au-PEIs) predetermined by synthetic routes of ligand exchange and reduction processes: Paths and Fates

June 17, 2019
Author(s)
Tae Joon Cho, John M. Pettibone, Vincent A. Hackley
Polyethyleneimine (PEI) functionalized AuNPs (Au-PEIs) are have potent as positively charged gold nanoparticles (AuNPs) for nano-medicinal applications, due to their cationic surfaces that promote cellular uptake and gene transfection. 1-6 1-6 1-61-6 Au

Agglomeration of Escherichia coli with positively charged nanoparticles can lead to artifacts in a standard Caenorhabditis elegans toxicity assay

April 19, 2018
Author(s)
Shannon Hanna, Antonio Montoro Bustos, Alexander W. Peterson, Vytas Reipa, Leona D. Scanlan, Sanem Hosbas Coskun, Tae Joon Cho, Monique Johnson, Vincent A. Hackley, Bryant C. Nelson, Michael R. Winchester, John T. Elliott, Elijah Petersen
The increased use and incorporation of engineered nanoparticles (ENPs) in consumer products requires a robust assessment of their potential environmental implications. However, a lack of standardized methods for nanotoxicity testing has yielded results

Surface Modification of Cisplatin-Complexed Gold Nanoparticles and Its Influence on Colloidal Stability, Drug Loading, and Drug Release

November 10, 2017
Author(s)
Jiaojie Tan, Tae Joon Cho, De-Hao Tsai, Jingyu Liu, John M. Pettibone, Rian You, Michael R. Zachariah, Vincent A. Hackley
Cisplatin-complexed gold nanoparticles (PtII-AuNP) provide a promising strategy for chemo- radiation based anticancer drugs. Effective design of such platforms necessitates reliable assessment of surface engineering on a quantitative basis, and its

Orthogonal Analysis of Functional Gold Nanoparticles for Biomedical Applications

September 11, 2015
Author(s)
De-Hao D. Tsai, Yi-Fu Lu, Frank W. DelRio, Tae Joon Cho, Suvajyoti S. Guha, Michael R. Zachariah, Fan Zhang, Andrew J. Allen, Vincent A. Hackley
We report a comprehensive strategy based on implementation of orthogonal measurement techniques to provide critical and verifiable material characteristics for functionalized gold nanoparticles (AuNPs) used in biomedical applications. Thiolated

Highly Stable Positively Charged Dendron-Encapsulated Gold Nanoparticles

March 13, 2014
Author(s)
Tae Joon Cho, Robert I. MacCuspie, Julien C. Gigault, Justin M. Gorham, John T. Elliott, Vincent A. Hackley
We report the development of a novel cationic dendron (TAG1-PCD) and a positively charged gold nanoparticle-dendron conjugate (PCD-AuNP). TAG1-PCD was designed by considering the reactivity, hydrophilicity, and cationic nature that is required to yield a

Controlled Formation and Characterization of Dithiothreitol-Conjugated Gold Nanoparticle Clusters

March 5, 2014
Author(s)
De-Hao D. Tsai, Tae Joon Cho, Frank W. DelRio, Justin Gorham, Jiwen Zheng, Jiaojie Tan, Michael R. Zachariah, Vincent A. Hackley
We report a systematic study of the controlled formation of discrete-size gold nanoparticle clusters (GNCs) by interaction with the reducing agent dithiothreitol (DTT). Asymmetric-flow field flow fractionation and electrospray differential mobility
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