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Search Publications by: Michihiro Nagao (Assoc)

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Displaying 1 - 25 of 33

Investigating the Effect of Medium Chain Triglycerides on the Elasticity of Pulmonary Surfactant

April 17, 2023
Author(s)
Dominik Dziura, Stuart R. Castillo, Mitchell DiPasquale, Omotaya Gbadamosi, Piotr Zolnierczuk, Michihiro Nagao, Elizabeth Kelley, Drew Marquardt
In recent years, vaping has increased in both popularity and ease of access. This has led to an outbreak of a relatively new condition known as e-cigarette/vaping-associated lung injury (EVALI). This injury can be caused by physical interactions between

Nanoscale Bending Dynamics in Mixed-Chain Lipid Membranes

January 9, 2023
Author(s)
Elizabeth Kelley, Moritz Frewein, Orsolya Czakkel, Michihiro Nagao
Lipids that have two tails of different lengths are found throughout biomembranes in nature, yet the effects of this asymmetry on the membrane properties, are not well understood, especially when it comes to the membrane dynamics. Here we study the

Probing the Link between Pancratistatin and Mitochondrial Apoptosis through Changes in the Membrane Dynamics on the Nanoscale

June 6, 2022
Author(s)
Stuart R. Castillo, Brett W. Rickeard, Mitchell DiPasquale, Michael H. Nguyen, Aislyn Lewis-Laurent, Milka Doktorova, Batuhan Kav, Markus S. Miettinen, Michihiro Nagao, Elizabeth Kelley, Drew Marquardt
Pancratistatin (PST) is a natural antiviral alkaloid that has demonstrated specificity towards cancerous cells and explicitly targets the mitochondria. PST initiates apoptosis while leaving healthy, noncancerous cells unscathed. However, the manner by

Relationship between Viscosity and Acyl Tail Dynamics in Lipid Bilayers

August 12, 2021
Author(s)
Michihiro Nagao, Elizabeth Kelley, Antonio Faraone, Makina Saito, Yoshitaka Yoda, Masayuki Kurokuzu, Shinichi Takata, Makoto Seto, Paul Butler
Membrane viscosity is a fundamental property that controls molecular transport and structural rearrangements in lipid membranes. Given its importance in many cell processes, various experimental and computational methods have been developed to measure the

Collective Dynamics in Lipid Membranes Containing Transmembrane Peptides

June 21, 2021
Author(s)
Elizabeth Kelley, Paul Butler, Michihiro Nagao
Biological membranes are composed of complex mixtures of lipids and proteins that influence each other's structure and function. The biological activities of many channel-forming peptides and proteins are known to depend on the material properties of the

Enhance Dynamics in the Anomalous Melting Regime of DMPG Lipid Membranes

October 16, 2020
Author(s)
Elizabeth Kelley, Michihiro Nagao, Paul Butler, Lionel Porcar, Bela Farago
Like many soft materials, lipids undergo a melting transition associated with a significant increase in their dynamics. At temperatures below the main melting transition (T m), all molecular and collective dynamics are suppressed, while above T m the alkyl

Scaling Relationships for the Elastic Moduli and Viscosity of Mixed Lipid Membranes

September 21, 2020
Author(s)
Elizabeth Kelley, Paul Butler, Rana Ashkar, Robert Bradbury, Michihiro Nagao
The elastic and viscous properties of biological membranes play a vital role in controlling cell functions that require local reorganization of the membrane components as well as dramatic shape changes such as endocytosis, vesicular trafficking, and cell

Interleaflet Coupling of n-Alkane Incorporated Bilayers

March 14, 2020
Author(s)
Hatsuho Usuda, Mafumi Hishida, Elizabeth Kelley, Yasuhisa Yamamura, Michihiro Nagao, Kazuya Saito
The relationship between the membrane bending modulus (k) and compressibility modulus (KA) depends on the extent of coupling between the two monolayers (leaflets). Using neutron spin echo (NSE) spectroscopy, we investigate the effects of n-alkanes on the

Transverse Lipid Organization Dictates Bending Fluctuations in Model Plasma Membranes

January 21, 2020
Author(s)
Brett W. Rickeard, Michael H. Nguyen, Mitchell DiPasquale, Caesar G. Yip, Hamilton Baker, Frederick A. Heberle, Xiaobing Zuo, Elizabeth Kelley, Michihiro Nagao, Drew Marquardt
Bending fluctuation is one of the most important dynamic modes of lipid membranes. These fluctuations play a vital role in many biological processes, most notoriously, contributing to the regulation of membrane protein activity. We investigated the bending

Tailoring Biomimetic Phosphorylcholine-Containing Block Copolymers as Membrane-Targeting Cellular Rescue Agents

September 9, 2019
Author(s)
Jia-Yu Wang, Wei Chen, Michihiro Nagao, Phullara Shelat, Brenton A. G. Hammer, Gregory T. Tietjen, Kathleen Cao, J. Michael Henderson, Lilin He, Binhua Lin, Bulent Akgun, Mati Meron, Shuo Qian, Sarah Ward, Jeremy D. Marks, Todd Emrick, Ka Yee C. Lee
Some synthetic polymers have been found capable of rescuing injured cells from death by targeting cell membranes. However, general principles for designing synthetic polymers to ensure strong, but non-disruptive cell membrane targeting unknown. Here, we

Scaling of Lipid Membrane Rigidity with Domain Area Fraction

February 21, 2019
Author(s)
Elizabeth G. Kelley, Michihiro Nagao, Paul D. Butler
The elastic properties of cell membranes play a vital role in controlling the morphology changes necessary for cell processes such as endocytosis and cell division. These elastic properties are highly sensitive to the lipid composition and distribution

Two Inherent Crossovers of the Diffusion Process in Glass-Forming Liquids

October 5, 2018
Author(s)
Maiko Kofu, Antonio Faraone, Madhu Sudan Tyagi, Michihiro Nagao, Osamu Yamamuro
We report on incoherent quasielastic neutron scattering measurements examining a self-diffusion process in two types of glass-forming liquids, a molecular liquid (3-methylpentane) and an ionic liquid (1-butyl-3-methylimidazolium bis

Effect of Interlamellar Interactions on Shear Induced Multilamellar Vesicles Formation

July 21, 2017
Author(s)
Youhei Kawabata, Robert David Bradbury, S. Kugizaki, Kathleen Weigandt, Y. B. Melnichenko, K. Sadakane, N. L. Yamada, H. Endo, Michihiro Nagao, H. Seto
Shear-induced multilamellar vesicle (MLV) formation has been studied by means of small-angle neutron scattering (SANS) technique coupled with neutron spin echo (NSE) spectroscopy. A mass fraction of 10% of nonionic surfactant pentaethylene glycol dodecyl

Effect of Charge on the Mechanical Properties of Surfactant Bilayers

November 23, 2016
Author(s)
Robert David Bradbury, Michihiro Nagao
The viscoelastic properties of surfactant bilayers have been measured over a range of surface charge densities, for a system with a low ionic strength, using small-angle neutron scattering and neutron spin echo (NSE) spectroscopy. An increase in the

Neutron Polarization Analysis for Biphasic Solvent Extraction Systems

June 16, 2016
Author(s)
Ryuhei Motokawa, Hitoshi Endo, Michihiro Nagao, William T. Heller
We performed neutron polarization analysis (NPA) of extracted organic phases containing complexes, comprised of Zr(NO 3( 4 and tri-n-butyl phosphate (TBP), to decompose the intensity distribution of small-angle neutron scattering (SANS) into the coherent

Mechanism of Spontaneous Blebbing Motion of Oil-Water Interface: Elastic Stress Generated by a Lamellar-Lamellar Transition

March 3, 2016
Author(s)
Yutaka Sumino, Norifumi L. Yamada, Michihiro Nagao, Takuya Honda, Hiroyuki Kitahata, Yuri B. Melnichenko, Hideki Seto
A mimic of biological blebbing motions constructed by a purely chemical system has been studied to understand nanometer scale structure and their roles in the spontaneous motion. Transition of surfactant lamellar phase was away rom the interface

Nanostructures and Dynamics of Macromolecules Bound to Attractive Filler Surfaces

August 18, 2015
Author(s)
Naisheng Jiang, Maya K. Endoh, Tadanori Koga, Tomomi Masui, Hiroyuki Kishimoto, Michihiro Nagao, Sushil K. Satija, Takashi Taniguchi
We report in-situ structures and dynamics of polybutadiene (PB) chains bound to carbon black (CB) fillers (the so-called "bound polymer layer (BPL)") in a good solvent. The BPL on the CB fillers were extracted by solvent leaching of a CB-filled PB compound