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Search Publications by

Michihiro Nagao (Assoc)

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Displaying 1 - 25 of 28

Collective Dynamics in Lipid Membranes Containing Transmembrane Peptides

June 21, 2021
Elizabeth Kelley, Paul Butler, Michihiro Nagao
Biological membranes are composed of complex mixtures of lipids and proteins that influence each other's structure and function. The biological activities of many channel-forming peptides and proteins are known to depend on the material properties of the

Enhance Dynamics in the Anomalous Melting Regime of DMPG Lipid Membranes

October 16, 2020
Elizabeth Kelley, Michihiro Nagao, Paul Butler, Lionel Porcar, Bela Farago
Like many soft materials, lipids undergo a melting transition associated with a significant increase in their dynamics. At temperatures below the main melting transition (Tm), all molecular and collective dynamics are suppressed, while above Tm the alkyl

Scaling Relationships for the Elastic Moduli and Viscosity of Mixed Lipid Membranes

September 21, 2020
Elizabeth Kelley, Paul Butler, Rana Ashkar, Robert Bradbury, Michihiro Nagao
The elastic and viscous properties of biological membranes play a vital role in controlling cell functions that require local reorganization of the membrane components as well as dramatic shape changes such as endocytosis, vesicular trafficking, and cell

Interleaflet Coupling of n-Alkane Incorporated Bilayers

March 14, 2020
Hatsuho Usuda, Mafumi Hishida, Elizabeth Kelley, Yasuhisa Yamamura, Michihiro Nagao, Kazuya Saito
The relationship between the membrane bending modulus (k) and compressibility modulus (KA) depends on the extent of coupling between the two monolayers (leaflets). Using neutron spin echo (NSE) spectroscopy, we investigate the effects of n-alkanes on the

Transverse Lipid Organization Dictates Bending Fluctuations in Model Plasma Membranes

January 21, 2020
Brett W. Rickeard, Michael H. Nguyen, Mitchell DiPasquale, Caesar G. Yip, Hamilton Baker, Frederick A. Heberle, Xiaobing Zuo, Elizabeth Kelley, Michihiro Nagao, Drew Marquardt
Bending fluctuation is one of the most important dynamic modes of lipid membranes. These fluctuations play a vital role in many biological processes, most notoriously, contributing to the regulation of membrane protein activity. We investigated the bending

Tailoring Biomimetic Phosphorylcholine-Containing Block Copolymers as Membrane-Targeting Cellular Rescue Agents

September 9, 2019
Jia-Yu Wang, Wei Chen, Michihiro Nagao, Phullara Shelat, Brenton A. G. Hammer, Gregory T. Tietjen, Kathleen Cao, J. Michael Henderson, Lilin He, Binhua Lin, Bulent Akgun, Mati Meron, Shuo Qian, Sarah Ward, Jeremy D. Marks, Todd Emrick, Ka Yee C. Lee
Some synthetic polymers have been found capable of rescuing injured cells from death by targeting cell membranes. However, general principles for designing synthetic polymers to ensure strong, but non-disruptive cell membrane targeting unknown. Here, we

Scaling of Lipid Membrane Rigidity with Domain Area Fraction

February 21, 2019
Elizabeth G. Kelley, Michihiro Nagao, Paul D. Butler
The elastic properties of cell membranes play a vital role in controlling the morphology changes necessary for cell processes such as endocytosis and cell division. These elastic properties are highly sensitive to the lipid composition and distribution

Two Inherent Crossovers of the Diffusion Process in Glass-Forming Liquids

October 5, 2018
Maiko Kofu, Antonio Faraone, Madhu Sudan Tyagi, Michihiro Nagao, Osamu Yamamuro
We report on incoherent quasielastic neutron scattering measurements examining a self-diffusion process in two types of glass-forming liquids, a molecular liquid (3-methylpentane) and an ionic liquid (1-butyl-3-methylimidazolium bis

Effect of Interlamellar Interactions on Shear Induced Multilamellar Vesicles Formation

July 21, 2017
Youhei Kawabata, Robert David Bradbury, S. Kugizaki, Kathleen Weigandt, Y. B. Melnichenko, K. Sadakane, N. L. Yamada, H. Endo, Michihiro Nagao, H. Seto
Shear-induced multilamellar vesicle (MLV) formation has been studied by means of small-angle neutron scattering (SANS) technique coupled with neutron spin echo (NSE) spectroscopy. A mass fraction of 10% of nonionic surfactant pentaethylene glycol dodecyl

Effect of Charge on the Mechanical Properties of Surfactant Bilayers

November 23, 2016
Robert David Bradbury, Michihiro Nagao
The viscoelastic properties of surfactant bilayers have been measured over a range of surface charge densities, for a system with a low ionic strength, using small-angle neutron scattering and neutron spin echo (NSE) spectroscopy. An increase in the

Neutron Polarization Analysis for Biphasic Solvent Extraction Systems

June 16, 2016
Ryuhei Motokawa, Hitoshi Endo, Michihiro Nagao, William T. Heller
We performed neutron polarization analysis (NPA) of extracted organic phases containing complexes, comprised of Zr(NO3(4 and tri-n-butyl phosphate (TBP), to decompose the intensity distribution of small-angle neutron scattering (SANS) into the coherent and

Mechanism of Spontaneous Blebbing Motion of Oil-Water Interface: Elastic Stress Generated by a Lamellar-Lamellar Transition

March 3, 2016
Yutaka Sumino, Norifumi L. Yamada, Michihiro Nagao, Takuya Honda, Hiroyuki Kitahata, Yuri B. Melnichenko, Hideki Seto
A mimic of biological blebbing motions constructed by a purely chemical system has been studied to understand nanometer scale structure and their roles in the spontaneous motion. Transition of surfactant lamellar phase was away rom the interface

Nanostructures and Dynamics of Macromolecules Bound to Attractive Filler Surfaces

August 18, 2015
Naisheng Jiang, Maya K. Endoh, Tadanori Koga, Tomomi Masui, Hiroyuki Kishimoto, Michihiro Nagao, Sushil K. Satija, Takashi Taniguchi
We report in-situ structures and dynamics of polybutadiene (PB) chains bound to carbon black (CB) fillers (the so-called "bound polymer layer (BPL)") in a good solvent. The BPL on the CB fillers were extracted by solvent leaching of a CB-filled PB compound

Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity

April 15, 2014
Eric J. Yearley, Paul D. Godfrin, Tatiana NMN Perevozchikova, Hailiang Zhang, Peter Falus, Lionel Porcar, Michihiro Nagao, Joseph E. Curtis, Pradad Gawande, Rosalynn Taing, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. Some concentrated mAb solutions are hypothesized to exhibit the formation of a solution phase consisting of reversibly self-associated aggregates (or reversible clusters), which is

Quasi-elastic Neutron Scattering Studies on Dynamics of Water Confined in Nanoporous Copper Rubeanate Hydrates

October 14, 2011
Takeshi Yamada, Ryo Yonaimine, Teppei Yamada, Hiroshi Kitagawa, Madhu Sudan Tyagi, Michihiro Nagao, Osamu Yamamuro
We have investigated the mechanism of the first order transition and proton conductivity in copper rubeanate hydrates from microscopic and dynamical points of view. Three different types of neutron spectrometer, time of flight, back scattering and neutron