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Search Publications by: Yun Liu (Fed)

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Displaying 51 - 75 of 94

Modulation of Polypeptide Conformation through Donor-Acceptor Transformation of Side-Chain Hydrogen Bonding Ligands

July 1, 2017
Author(s)
Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson, Lichen Yin, Jianjun Chen
Synthetic polypeptides have received increasing attention due to their ability to form higher ordered structures similar to proteins. The control over their secondary structures, which enables dynamic conformational changes, is primarily accomplished by

Simultaneous Neutron and X-Ray Imaging of 3D Kerogen and Fracture Structure in Shales

June 17, 2017
Author(s)
Wei-Shan NMN Chiang, Jacob M LaManna, Daniel S. Hussey, David L. Jacobson, Yun Liu, Jilin Zhang, Daniel T. Georgi, Jin-hong Chen
Hydrocarbon production from shales using horizontal drilling and hydraulic fracturing has been the key development in US energy industry in the past decade and has now become more important globally. Nevertheless, many fundamental problems related to the

Rheology of clustering protein solutions

July 5, 2016
Author(s)
Vishnu Dharmaraj, P. Douglas Godfrin, Yun Liu, Steven Hudson
High viscosity is a major challenge with protein therapeutics at extremely high concentration. Understanding the relationship between the concentration of a protein solution and its viscosity as a function of shear rate and temperature is therefore

Supramolecular Hydrophobic Aggregates in Hydrogels Partially Inhibit Ice Formation

June 23, 2016
Author(s)
Clinton G. Wiener, Madhu Sudan Tyagi, Yun Liu, R. A. Weiss, Bryan D. Vogt
Prevention of ice crystallization is a challenging problem with implications in diverse applications, including the ability to examine the fundamental low temperature physics of water. Here, we demonstrate a simple route, inspired by water confinement in

Effect of Hierarchical Cluster Formation on the Viscosity of Concentrated Monoclonal Antibody Formulations Studied by Neutron Scattering

January 21, 2016
Author(s)
P. Douglas Godfrin, Isidro E. Zarraga, Jonathan Zarzar, Lionel Porcar, Peter Falus, Norman J. Wagner, Yun Liu
Recently, reversible cluster formation has been identified as an underlying cause of anomalously large solution viscosities observed in some concentrated monoclonal antibody (mAb) formulations. As high solution viscosity prevents the use of subcutaneous

Structural Changes and Aggregation Mechanisms for Anti-Streptavidin IgG1 at Elevated Concentration

December 10, 2015
Author(s)
Gregory V. Barnett, Wei Qi, Samiul Amin, E. Neil Lewis, Vladimir I. Razinkov, Bruce A. Kerwin, Yun Liu, Christopher J. Roberts
Non-native protein aggregation may occur during manufacturing and storage of protein therapeutics, and this may decrease drug efficacy or jeopardize patient safety. From a regulatory perspective, changes in higher-order structure due to aggregation are of

Short-Time Glassy Dynamics in Viscous Protein Solutions with Competing Interactions

November 27, 2015
Author(s)
P. Douglas Godfrin, Steven Hudson, Kunlun Hong, Lionel Porcar, Peter Falus, Norman J. Wagner, Yun Liu
Although there have been numerous investigations of the glass transition for colloidal dispersions with only a short range attraction (SA), less is understood for systems interacting with a SA and an additional longer range repulsion (LR), which is

Direct Observation of Critical Adsorption on Colloidal Particles

August 25, 2015
Author(s)
Christopher E Bertrand, P. D. Godfrin, Yun Liu
Despite the fundamental role adsorbed solvent layers play in generating critical Casimir forces between colloidal particles, the structure of these layers has yet to be directly determined. Using small-angle neutron scattering ,we have measured critical

Molecular Dynamics of a Model Dimerizing Fluid

January 28, 2015
Author(s)
Christopher E Bertrand, Yun Liu
A model dimer forming fluid has been investigated by continuous molecular dynamics simulations. This study emphasizes the volume fraction and temperature dependence of the static and dynamic properties of the systems, including the structure factor, self

Kinetic Trapping of D 2 in MIL-53(AL) Observed using Neutron Scattering

July 14, 2014
Author(s)
Rachel Ann Pollock, Jae-Hyuk Her, Craig Brown, Yun Liu, Anne Dailly
We have studied gas adsorption effects on the structure of a metal organic framework, MIL-53(Al), a material well known due to the controllable framework 'breathing¿ phenomenon. Neutron powder diffraction between 4 K and 77 K and up to 4.5 bar pressure D 2

Observation of Small Cluster Formation in Concentrated Monoclonal Antibody Solutions and Its Implications to Solution Viscosity

April 15, 2014
Author(s)
Eric J. Yearley, Paul D. Godfrin, Tatiana NMN Perevozchikova, Hailiang Zhang, Peter Falus, Lionel Porcar, Michihiro Nagao, Joseph E. Curtis, Pradad Gawande, Rosalynn Taing, Isidro E. Zarraga, Norman J. Wagner, Yun Liu
Monoclonal antibodies (mAbs) are a major class of biopharmaceuticals. Some concentrated mAb solutions are hypothesized to exhibit the formation of a solution phase consisting of reversibly self-associated aggregates (or reversible clusters), which is

Dynamical Arrest in Adhesive Hard-Sphere Dispersions Driven by Rigidity Percolation

December 6, 2013
Author(s)
Nestor E. Valadez-Perez, Yun Liu, Aaron P. R. Eberle, Norman J. Wagner, Ramon Castaneda-Priego
One major goal in condensed matter physics is identifying the physical mechanisms that lead to arrested states of matter, especially gels and glasses. The complex nature and microscopic details of each particular system are relevant. However, from both